Recombinant Mouse CXCL13/BLC/BCA-1 Protein | R&D Systems 470-BC-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CXCL13/BLC/BCA-1 Protein

catalog :

470-BC-025

quantity :

25 ug

price :

385 USD

citations: 20

Reference
Barakat R, Chatterjee J, Mu R, Qi X, Gu X, Smirnov I, et al. Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth. Nat Commun. 2024;15:10312 pubmed publisher
Wang J, Yin C, Pan Y, Yang Y, Li W, Ni H, et al. CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn. J Neuroinflammation. 2023;20:109 pubmed publisher
Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, et al. CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer. JCI Insight. 2022;7: pubmed publisher
Härzschel A, Li L, Krenn P, Szenes Nagy E, Andrieux G, Bayer E, et al. Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation. J Leukoc Biol. 2022;111:745-758 pubmed publisher
Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, et al. Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1. Sci Rep. 2017;7:7663 pubmed publisher
Burbage M, Keppler S, Montaner B, Mattila P, Batista F. The Small Rho GTPase TC10 Modulates B Cell Immune Responses. J Immunol. 2017;199:1682-1695 pubmed publisher
Garg R, Blando J, Perez C, Abba M, Benavides F, Kazanietz M. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Rep. 2017;19:375-388 pubmed publisher
Biajoux V, Natt J, Freitas C, Alouche N, Sacquin A, Hemon P, et al. Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization. Cell Rep. 2016;17:193-205 pubmed publisher
Geherin S, GÃ³mez D, Glabman R, Ruthel G, Hamann A, Debes G. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require Î±4Î²1 Integrin To Migrate between the Peritoneum and Inflamed Skin. J Immunol. 2016;196:2514-2525 pubmed publisher
Badr G, Sayed A, Abdel Maksoud M, Mohamed A, El Amir A, Abdel Ghaffar F, et al. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFÎºB and ERK. PLoS ONE. 2015;10:e0125340 pubmed publisher
Hwang I, Park C, Harrison K, Boularan C, GalÃ©s C, Kehrl J. An essential role for RGS protein/GÎ±i2 interactions in B lymphocyte-directed cell migration and trafficking. J Immunol. 2015;194:2128-39 pubmed publisher
Graham K, Zhang J, LewÃ©n S, BURKE T, Dang T, Zoudilova M, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS ONE. 2014;9:e112925 pubmed publisher
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K. Control of lymphocyte egress from lymph nodes through Î²2-adrenergic receptors. J Exp Med. 2014;211:2583-98 pubmed publisher
Moriyama S, Takahashi N, Green J, Hori S, Kubo M, Cyster J, et al. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014;211:1297-305 pubmed publisher
Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, et al. MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling. J Immunol. 2014;192:5273-84 pubmed publisher
Vaeth M, Müller G, Stauss D, Dietz L, Klein Hessling S, Serfling E, et al. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med. 2014;211:545-61 pubmed publisher
Hwang I, Hwang K, Park C, Harrison K, Kehrl J. Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE. 2013;8:e60139 pubmed publisher
Guo T, Landsman L, Li N, Hebrok M. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes. 2013;62:1581-92 pubmed publisher
Ippagunta S, Malireddi R, Shaw P, Neale G, Vande Walle L, Green D, et al. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol. 2011;12:1010-6 pubmed publisher

product information

master code :

470-BC

SKU :

470-BC-025

product name :

Recombinant Mouse CXCL13/BLC/BCA-1 Protein

unit size :

25 ug

description :

The Recombinant Mouse CXCL13/BLC/BCA-1 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CXCL13/BLC/BCA-1 Protein has been validated for the following applications: Bioactivity.

target :

CXCL13/BLC/BCA-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

9.8 kDa

gene symbol :

Cxcl13

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR5. The ED50 for this effect is 0.5-2á╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q3U1E8

applications :

Bioactivity

source long :

E. coli -derived mouse CXCL13/BLC/BCA-1 protein Ile22-Ala109

source short :

E. coli

USD :

385 USD

alt names :

ANGIE, ANGIE2, B cell-attracting chemokine 1, B lymphocyte chemoattractant, BCA1, BCA-1, BCA1B-cell chemoattractant, BCA-1CXC chemokine BLC, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), BLC, BLCSmall-inducible cytokine B13, BLR1L, B-lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), C-X-C motif chemokine 13, SCYB13, SCYB13B-cell-attracting chemokine 1, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.