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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse CXCL13/BLC/BCA-1 Protein
catalog :
470-BC-025
quantity :
25 ug
price :
385 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Wang J, Yin C, Pan Y, Yang Y, Li W, Ni H, et al. CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn. J Neuroinflammation. 2023;20:109 pubmed publisher
Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, et al. CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer. JCI Insight. 2022;7: pubmed publisher
Härzschel A, Li L, Krenn P, Szenes Nagy E, Andrieux G, Bayer E, et al. Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation. J Leukoc Biol. 2022;111:745-758 pubmed publisher
Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, et al. Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1. Sci Rep. 2017;7:7663 pubmed publisher
Burbage M, Keppler S, Montaner B, Mattila P, Batista F. The Small Rho GTPase TC10 Modulates B Cell Immune Responses. J Immunol. 2017;199:1682-1695 pubmed publisher
Garg R, Blando J, Perez C, Abba M, Benavides F, Kazanietz M. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Rep. 2017;19:375-388 pubmed publisher
Biajoux V, Natt J, Freitas C, Alouche N, Sacquin A, Hemon P, et al. Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization. Cell Rep. 2016;17:193-205 pubmed publisher
Geherin S, Gómez D, Glabman R, Ruthel G, Hamann A, Debes G. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin. J Immunol. 2016;196:2514-2525 pubmed publisher
Badr G, Sayed A, Abdel Maksoud M, Mohamed A, El Amir A, Abdel Ghaffar F, et al. Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFκB and ERK. PLoS ONE. 2015;10:e0125340 pubmed publisher
Hwang I, Park C, Harrison K, Boularan C, Galés C, Kehrl J. An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. J Immunol. 2015;194:2128-39 pubmed publisher
Graham K, Zhang J, Lewén S, BURKE T, Dang T, Zoudilova M, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS ONE. 2014;9:e112925 pubmed publisher
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K. Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors. J Exp Med. 2014;211:2583-98 pubmed publisher
Moriyama S, Takahashi N, Green J, Hori S, Kubo M, Cyster J, et al. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014;211:1297-305 pubmed publisher
Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, et al. MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling. J Immunol. 2014;192:5273-84 pubmed publisher
Vaeth M, Müller G, Stauss D, Dietz L, Klein Hessling S, Serfling E, et al. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med. 2014;211:545-61 pubmed publisher
Hwang I, Hwang K, Park C, Harrison K, Kehrl J. Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE. 2013;8:e60139 pubmed publisher
Guo T, Landsman L, Li N, Hebrok M. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes. 2013;62:1581-92 pubmed publisher
Ippagunta S, Malireddi R, Shaw P, Neale G, Vande Walle L, Green D, et al. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol. 2011;12:1010-6 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
470-BC
SKU :
470-BC-025
product name :
Recombinant Mouse CXCL13/BLC/BCA-1 Protein
description :
The Recombinant Mouse CXCL13/BLC/BCA-1 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CXCL13/BLC/BCA-1 Protein has been validated for the following applications: Bioactivity.
target :
CXCL13/BLC/BCA-1
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
9.8 kDa
gene symbol :
Cxcl13
details of functionality :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR5. The ED50 for this effect is 0.5-2 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q3U1E8
applications :
Bioactivity
product keywords :
470-BC, rmBLC/BCA-1, mBLC, 47O-BC,, 470BC, BCA1, CXCL 13, Chemokines, Chemokine, cytokine, cytokines, C-X-C Motif Chemokine Ligand 13, B Cell-Attracting Chemokine 1, Small-Inducible Cytokine B13, CXC Chemokine BLC, SCYB13, BCA-1, BCA1, B-Cell-Homing Chemokine (Ligand For Burkitt'S Lymphoma Recepto
source :
E. coli-derived Recombinant Mouse CXCL13/BLC/BCA-1 Protein
USD :
377
USD 2025 :
385 USD
alt names :
ANGIE, ANGIE2, B cell-attracting chemokine 1, B lymphocyte chemoattractant, BCA1, BCA-1, BCA1B-cell chemoattractant, BCA-1CXC chemokine BLC, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), BLC, BLCSmall-inducible cytokine B13, BLR1L, B-lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), C-X-C motif chemokine 13, SCYB13, SCYB13B-cell-attracting chemokine 1, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.