Recombinant Mouse gp130 Fc Chimera Protein, CF | R&D Systems 468-MG-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse gp130 Fc Chimera Protein, CF

catalog :

468-MG-100

quantity :

100 ug

price :

432 USD

citations: 10

Reference
Mukherjee S, Ghosh S, Bawali S, Chatterjee R, Saha A, Sengupta A, et al. Administration of soluble gp130Fc disrupts M-1 macrophage polarization, dendritic cell activation, MDSC expansion and Th-17 induction during experimental cerebral malaria. Int Immunopharmacol. 2023;123:110671 pubmed publisher
Bermick J, Watson S, Lueschow S, McElroy S. The fetal response to maternal inflammation is dependent upon maternal IL-6 in a murine model. Cytokine. 2023;167:156210 pubmed publisher
Yoshizaki S, Tamaru T, Hara M, Kijima K, Tanaka M, Konno D, et al. Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway. J Neuroinflammation. 2021;18:12 pubmed publisher
Robinson R, Youngblood H, Iyer H, Bloom J, Lee T, Chang L, et al. Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition. Invest Ophthalmol Vis Sci. 2020;61:2 pubmed publisher
Robinson R, Srinivasan M, Shanmugam A, Ward A, Ganapathy V, Bloom J, et al. Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy. Redox Biol. 2020;34:101574 pubmed publisher
Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, et al. Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages. Arthritis Res Ther. 2020;22:24 pubmed publisher
Dixit A, Bottek J, Beerlage A, Schuettpelz J, Thiebes S, Brenzel A, et al. Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling. J Leukoc Biol. 2017;: pubmed publisher
Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, et al. Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. Cancer Res. 2017;77:2279-2291 pubmed publisher
Lee M, Lee J, Choi J, Lee C, Sim J, Cho C, et al. Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. PLoS ONE. 2012;7:e38801 pubmed publisher
Jones G, McLoughlin R, Hammond V, Parker C, Williams J, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010;184:2130-9 pubmed publisher

product information

master code :

468-MG

SKU :

468-MG-100

product name :

Recombinant Mouse gp130 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse gp130 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse gp130 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

gp130

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

115 kDa, reducing conditions

theoretical molecular weight :

94 kDa (monomer)

gene symbol :

Il6st

details of functionality :

Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha (Catalog # 227-SR ). The ED50 for this effect is 0.12-1.2 ng/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse gp130 Fc Chimera Protein Bioactivity

accessionNumbers :

Q6PDI9

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse gp130 protein Mouse gp130 (Gln23-Glu617) Accession # Q6PDI9 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.