product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse gp130 Fc Chimera Protein, CF
catalog :
468-MG-100
quantity :
100 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Mukherjee S, Ghosh S, Bawali S, Chatterjee R, Saha A, Sengupta A, et al. Administration of soluble gp130Fc disrupts M-1 macrophage polarization, dendritic cell activation, MDSC expansion and Th-17 induction during experimental cerebral malaria. Int Immunopharmacol. 2023;123:110671 pubmed publisher
Bermick J, Watson S, Lueschow S, McElroy S. The fetal response to maternal inflammation is dependent upon maternal IL-6 in a murine model. Cytokine. 2023;167:156210 pubmed publisher
Yoshizaki S, Tamaru T, Hara M, Kijima K, Tanaka M, Konno D, et al. Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway. J Neuroinflammation. 2021;18:12 pubmed publisher
Robinson R, Youngblood H, Iyer H, Bloom J, Lee T, Chang L, et al. Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition. Invest Ophthalmol Vis Sci. 2020;61:2 pubmed publisher
Robinson R, Srinivasan M, Shanmugam A, Ward A, Ganapathy V, Bloom J, et al. Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy. Redox Biol. 2020;34:101574 pubmed publisher
Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, et al. Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages. Arthritis Res Ther. 2020;22:24 pubmed publisher
Dixit A, Bottek J, Beerlage A, Schuettpelz J, Thiebes S, Brenzel A, et al. Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling. J Leukoc Biol. 2017;: pubmed publisher
Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, et al. Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. Cancer Res. 2017;77:2279-2291 pubmed publisher
Lee M, Lee J, Choi J, Lee C, Sim J, Cho C, et al. Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. PLoS ONE. 2012;7:e38801 pubmed publisher
Jones G, McLoughlin R, Hammond V, Parker C, Williams J, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010;184:2130-9 pubmed publisher
image
image 1 :
R&D Systems 468-MG-100 image 1
Recombinant Mouse gp130 Fc Chimera Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
468-MG
SKU :
468-MG-100
product name :
Recombinant Mouse gp130 Fc Chimera Protein, CF
Description :
The Recombinant Mouse gp130 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse gp130 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
gp130
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
115 kDa, reducing conditions
theoretical molecular weight :
94 kDa (monomer)
gene symbol :
Il6st
details of functionality :
Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha (Catalog # 227-SR ). The ED50 for this effect is 0.12-1.2 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q6PDI9
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse gp130 Fc Chimera Protein
USD :
423 USD
alt names :
CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.