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company name :
R&D Systems
product type :
other
product name :
Universal Colorimetric PARP Assay Kit - Histone-Coated Wells
catalog :
4677-096-K
quantity :
1 Kit
price :
566 USD
more info or order :
citations: 33
Reference
Guha Majumdar A, Shree S, Das A, Kumar B, Dey P, Subramanian M, et al. Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells. Eur J Med Chem. 2023;258:115598 pubmed publisher
Neves K, Alves Lopes R, Montezano A, Touyz R. Role of PARP and TRPM2 in VEGF Inhibitor-Induced Vascular Dysfunction. J Am Heart Assoc. 2023;12:e027769 pubmed publisher
Gao H, Cui J, Liu S, Wang S, Lian Y, Bai Y, et al. Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize. Mol Plant. 2022;15:1558-1574 pubmed publisher
Cremona M, Vandenberg C, Farrelly A, Madden S, Morgan C, Kalachand R, et al. BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors. Br J Cancer. 2022;127:488-499 pubmed publisher
Toli x107 A, Ravichandran M, Raji x107 J, x110 or x111 evi x107 M, x110 or x111 evi x107 M, Dini x107 S, et al. TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation. Epigenetics Chromatin. 2022;15:11 pubmed publisher
Khashab F, Al Saleh F, Al Kandari N, Fadel F, Al Maghrebi M. JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway. Int J Mol Sci. 2021;22: pubmed publisher
Nikoleousakos N, Dalezis P, Polonifi A, Geromichalou E, Sagredou S, Alifieris C, et al. Cytocidal Antitumor Effects against Human Ovarian Cancer Cells Induced by B-Lactam Steroid Alkylators with Targeted Activity against Poly (ADP-Ribose) Polymerase (PARP) Enzymes in a Cell-Free Assay. Biomedicines. 2021;9: pubmed publisher
Wang L, Zhu X, Li L, Li L, Fu L, Li Y, et al. TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models. Am J Cancer Res. 2021;11:1632-1645 pubmed
Zhang F, Wang C, Jiang Y, Huang K, Liu F, Du M, et al. Yin and Yang Regulation of Liver X Receptor α Signaling Control of Cholesterol Metabolism by Poly(ADP-ribose) polymerase 1. Int J Biol Sci. 2020;16:2868-2882 pubmed publisher
Li H, Tu J, Zhao Z, Chen L, Qu Y, Li H, et al. Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. Theranostics. 2020;10:9477-9494 pubmed publisher
Al Saleh F, Khashab F, Fadel F, Al Kandari N, Al Maghrebi M. Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury. Saudi J Biol Sci. 2020;27:2174-2184 pubmed publisher
Li R, Deng Y, Pham H, Weiss S, Chen M, Smith P. Riluzole protects against skeletal muscle ischaemia-reperfusion injury in a porcine model. Injury. 2020;51:178-184 pubmed publisher
Yoshimura Y. Increased error-free DNA repair gene expression through reprogramming in human iPS cells. Regen Ther. 2019;11:101-105 pubmed publisher
Alqahtani S, Welton K, Gius J, Elmegerhi S, Kato T. The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition. Int J Mol Sci. 2019;20: pubmed publisher
Wang C, Xu W, An J, Liang M, Li Y, Zhang F, et al. Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. Nat Commun. 2019;10:1203 pubmed publisher
Trafalis D, Polonifi A, Dalezis P, Nikoleousakos N, Katsamakas S, Sarli V. Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells. Chem Biol Drug Des. 2017;90:854-866 pubmed publisher
Zakaria E, El Maraghy N, Ahmed A, Ali A, El Bassossy H. PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:621-631 pubmed publisher
Chen Y, Bang S, Park S, Shi H, Kim S. Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1. Biochem J. 2015;469:189-98 pubmed publisher
Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, et al. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol Cell Biol. 2015;35:2425-35 pubmed publisher
Wang J, Liu L, Xia Y, Wu D. Silencing of poly(ADP-ribose) polymerase-1 suppresses hyperstretch-induced expression of inflammatory cytokines in vitro. Acta Biochim Biophys Sin (Shanghai). 2014;46:556-64 pubmed publisher
To C, Kim E, Royce D, Williams C, Collins R, Risingsong R, et al. The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. Cancer Prev Res (Phila). 2014;7:698-707 pubmed publisher
Jelinic P, Levine D. New insights into PARP inhibitors' effect on cell cycle and homology-directed DNA damage repair. Mol Cancer Ther. 2014;13:1645-54 pubmed publisher
Jasek E, Gajda M, Lis G, Jasińska M, Litwin J. Combinatorial effects of PARP inhibitor PJ34 and histone deacetylase inhibitor vorinostat on leukemia cell lines. Anticancer Res. 2014;34:1849-56 pubmed
Thurber G, Reiner T, Yang K, Kohler R, Weissleder R. Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Mol Cancer Ther. 2014;13:986-95 pubmed publisher
Wang C, Zhang F, Wang L, Zhang Y, Li X, Huang K, et al. Poly(ADP-ribose) polymerase 1 promotes oxidative-stress-induced liver cell death via suppressing farnesoid X receptor ?. Mol Cell Biol. 2013;33:4492-503 pubmed publisher
Jouan Lanhouet S, Arshad M, Piquet Pellorce C, Martin Chouly C, Le Moigne Müller G, Van Herreweghe F, et al. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ. 2012;19:2003-14 pubmed publisher
Dutta C, Day T, Kopp N, Van Bodegom D, Davids M, Ryan J, et al. BCL2 suppresses PARP1 function and nonapoptotic cell death. Cancer Res. 2012;72:4193-203 pubmed publisher
Ma W, Halweg C, Menendez D, Resnick M. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012;109:6590-5 pubmed publisher
Rajesh M, Batkai S, Kechrid M, Mukhopadhyay P, Lee W, Horváth B, et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes. 2012;61:716-27 pubmed publisher
Martínez Romero R, Cañuelo A, Siles E, Oliver F, Martinez Lara E. Nitric oxide modulates hypoxia-inducible factor-1 and poly(ADP-ribose) polymerase-1 cross talk in response to hypobaric hypoxia. J Appl Physiol (1985). 2012;112:816-23 pubmed publisher
Noren Hooten N, Kompaniez K, Barnes J, Lohani A, Evans M. Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1). J Biol Chem. 2011;286:44679-90 pubmed publisher
Meador J, Zhao M, Su Y, Narayan G, Geard C, Balajee A. Histone H2AX is a critical factor for cellular protection against DNA alkylating agents. Oncogene. 2008;27:5662-71 pubmed publisher
Mathews M, Berk B. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler Thromb Vasc Biol. 2008;28:711-7 pubmed publisher
product information
brand :
R&D Systems
master code :
4677-096-K
SKU :
4677-096-K
product name :
Universal Colorimetric PARP Assay Kit - Histone-Coated Wells
unit size :
1 Kit
target :
PARP
category :
DNA Damage and Repair Kits
species :
Multi-Species
top caption :
Inhibition of PARP Activity by 3-aminobenzamide_4677-096-K
USD :
566 USD
alt names :
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADPRT, ADPRT 1, ADPRTADP-ribosyltransferase NAD(+), EC 2.4.2, EC 2.4.2.30, NAD(+) ADP-ribosyltransferase 1, PARP apoptosis, PARP1, PARP-1, PARPADPRT1, poly (ADP-ribose) polymerase 1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) polymerase, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, PPOL, PPOLpADPRT-1
storage :
The product requires storage at both -20 to -70 ░C and 2 - 8 ░C. Consult the product insert for specific storage temperatures.áDo not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.