Recombinant Mouse EphB2 Fc Chimera Protein, CF | R&D Systems 467-B2-200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse EphB2 Fc Chimera Protein, CF

catalog :

467-B2-200

quantity :

200 ug

price :

348 USD

citations: 18

Reference
Larra xf1 aga E, Marín Riera M, Abad L xe1 zaro A, Bartolom xe9 Catal xe0 D, Otero A, Fern xe1 ndez Majada V, et al. Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning. Nat Commun. 2025;16:382 pubmed publisher
Guo S, Wang Y, Duan Q, Gu W, Fu Q, Ma Z, et al. Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation. Front Pharmacol. 2024;15:1463339 pubmed publisher
Chen Y, Huang C, Du F, Xiao Z, Qian W, Bai T, et al. EphB2 promotes enteric nitrergic hyperinnervation and neurogenic inflammation in DSS-induced chronic colitis in mice. Int Immunopharmacol. 2024;129:111591 pubmed publisher
Zhang G, Brady J, Liang W, Wu Y, Henkemeyer M, Yan M. EphB4 forward signalling regulates lymphatic valve development. Nat Commun. 2015;6:6625 pubmed publisher
Muto A, Yi T, Harrison K, Davalos A, Fancher T, Ziegler K, et al. Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. J Exp Med. 2011;208:561-75 pubmed publisher
Nomura T, Goritz C, Catchpole T, Henkemeyer M, Frisen J. EphB signaling controls lineage plasticity of adult neural stem cell niche cells. Cell Stem Cell. 2010;7:730-43 pubmed publisher
Pittman A, Gaynes J, Chien C. nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system. Dev Biol. 2010;344:784-94 pubmed publisher
Genander M, Holmberg J, Frisen J. Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells. 2010;28:1196-205 pubmed publisher
Passante L, Gaspard N, Degraeve M, Frisen J, Kullander K, De Maertelaer V, et al. Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum. Development. 2008;135:3281-90 pubmed publisher
Xing S, He Y, Ling L, Hou Q, Yu J, Zeng J, et al. Blockade of EphB2 enhances neurogenesis in the subventricular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Brain Res. 2008;1230:237-46 pubmed publisher
Mellott D, Burke R. Divergent roles for Eph and ephrin in avian cranial neural crest. BMC Dev Biol. 2008;8:56 pubmed publisher
Lim B, Matsuda N, Poo M. Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo. Nat Neurosci. 2008;11:160-9 pubmed publisher
Chaudhari A, Mahfouz M, Fialho A, Yamada T, Granja A, Zhu Y, et al. Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry. 2007;46:1799-810 pubmed
Yang N, Pasquale E, Owen L, Ethell I. The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem. 2006;281:32574-86 pubmed
Holmberg J, Genander M, Halford M, Annerén C, Sondell M, Chumley M, et al. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell. 2006;125:1151-63 pubmed
Ogawa K, Wada H, Okada N, Harada I, Nakajima T, Pasquale E, et al. EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases. J Cell Sci. 2006;119:559-70 pubmed
Davy A, Aubin J, Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004;18:572-83 pubmed
Murai K, Nguyen L, Irie F, Yamaguchi Y, Pasquale E. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-60 pubmed

product information

master code :

467-B2

SKU :

467-B2-200

product name :

Recombinant Mouse EphB2 Fc Chimera Protein, CF

unit size :

200 ug

description :

The Recombinant Mouse EphB2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse EphB2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

EphB2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

85.3 kDa (monomer)

gene symbol :

Ephb2

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rmEphB2/Fc Chimera at 2 ╡g/mL (100 ╡L/well) can bind rmEphrin-B2/Fc Chimera with a linear range of 0.039-2.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P54763

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse EphB2 protein Mouse EphB2 (Val27-Lys548) Accession # P54763 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

348 USD

alt names :

CAPB, Cek5, Drt, DRTEphB2, EC 2.7.10, EC 2.7.10.1, EK5, elk-related tyrosine kinase, EPH receptor B2, eph tyrosine kinase 3, EPH-like kinase 5, ephrin type-B receptor 2, EPHT3MGC87492, EPTH3, Erk, ERKHek5, HEK5, Nuk, PCBC, protein-tyrosine kinase HEK5, Qek2, Renal carcinoma antigen NY-REN-47, Sek3, Tyro5, Tyrosine-protein kinase receptor EPH-3, Tyrosine-protein kinase TYRO5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.