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company name :
R&D Systems
product type :
other
product name :
Recombinant Human PARP Enzyme (HSA)
catalog :
4668-100-01
quantity :
1000 UN
price :
315 USD
more info or order :
R&D Systems product webpage
citations: 20
Reference
Shafiq M, Lone Z, Abdulkareem A, Kaur G, Navya S, Singh H, et al. Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension. Pulm Pharmacol Ther. 2023;80:102200 pubmed publisher
Laspata N, Kaur P, Mersaoui S, Muoio D, Liu Z, Bannister M, et al. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023;51:2215-2237 pubmed publisher
Zhang Y, Fang M, Li S, Xu H, Ren J, Tu L, et al. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer. Mol Cancer. 2022;21:158 pubmed publisher
Nagy P xe9 nzes M, Hajn xe1 dy Z, Regdon Z, Dem xe9 ny M, Kov xe1 cs K, El Hamoly T, et al. Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling. Biomedicines. 2022;10: pubmed publisher
Tanaka M, Mushiake M, Takahashi J, Sasaki Y, Yamashita S, Ida C, et al. PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells. Int J Mol Sci. 2022;23: pubmed publisher
Adamowicz M, Hailstone R, Demin A, Komulainen E, Hanzlikova H, Brazina J, et al. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nat Cell Biol. 2021;23:1287-1298 pubmed publisher
Hsieh A, Pitarresi J, Lerner J, Donahue G, Hsiehchen D, Rustgi A, et al. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Sci Adv. 2020;6: pubmed publisher
Iglesias P, Seoane M, Golán I, Castro Piedras I, Fraga M, Arce V, et al. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer. Cancers (Basel). 2020;12: pubmed publisher
Talhaoui I, Lebedeva N, Zarkovic G, Saint Pierre C, Kutuzov M, Sukhanova M, et al. Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro. Nucleic Acids Res. 2016;44:9279-9295 pubmed
Silva A, Ryan D, Galanty Y, Low J, Vandevenne M, Jackson S, et al. The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose). J Biol Chem. 2016;291:924-38 pubmed publisher
Khadka P, Hsu J, Veith S, Tadokoro T, Shamanna R, Mangerich A, et al. Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities. Mol Cell Biol. 2015;35:3974-89 pubmed publisher
Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, et al. An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks. Nucleic Acids Res. 2015;43:3167-79 pubmed publisher
Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, et al. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev. 2015;29:157-70 pubmed publisher
Khoury Haddad H, Guttmann Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E728-37 pubmed publisher
Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo Rodriguez K, Hanni M, et al. Molecular tweezers with varying anions: a comparative study. J Org Chem. 2013;78:6721-34 pubmed publisher
MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acids Res. 2013;41:1604-21 pubmed publisher
Gottschalk A, Trivedi R, Conaway J, Conaway R. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate. J Biol Chem. 2012;287:43527-32 pubmed publisher
King B, Cooper K, Liu K, Hudson L. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. J Biol Chem. 2012;287:39824-33 pubmed publisher
Wright R, Castellano G, Bonet J, Le Dily F, Font Mateu J, Ballaré C, et al. CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells. Genes Dev. 2012;26:1972-83 pubmed publisher
Narwal M, Fallarero A, Vuorela P, Lehtiö L. Homogeneous screening assay for human tankyrase. J Biomol Screen. 2012;17:593-604 pubmed publisher
product information
brand :
R&D Systems
master code :
4668-100-01
SKU :
4668-100-01
product name :
Recombinant Human PARP Enzyme (HSA)
unit size :
1000 UN
target :
PARP
category :
Activity Assays
species :
Multi-Species
USD :
315 USD
alt names :
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADPRT, ADPRT 1, ADPRTADP-ribosyltransferase NAD(+), EC 2.4.2, EC 2.4.2.30, NAD(+) ADP-ribosyltransferase 1, PARP apoptosis, PARP1, PARP-1, PARPADPRT1, poly (ADP-ribose) polymerase 1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) polymerase, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, PPOL, PPOLpADPRT-1
storage :
Store at -20 ░C in a manual defrost freezer. For long-term storage, freeze in working aliquots at -80 ░C. Avoid freeze-thaw cycles.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.