product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse CXCL10/IP-10/CRG-2 Protein
catalog :
466-CR-010
quantity :
10 ug
price :
291 USD
more info or order :
R&D Systems product webpage
citations: 17
Reference
Sato T, Ishihara S, Marui R, Takagi J, Katagiri K. Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies. Sci Rep. 2020;10:13221 pubmed publisher
Carroll J, Groveman B, Williams K, Moore R, Race B, Haigh C. Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells. Sci Rep. 2020;10:6654 pubmed publisher
Xu Y, Lv L, Liu Y, Smith M, Li W, Tan X, et al. Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. J Clin Invest. 2019;130: pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
Zhao Q, Kim T, Pang J, Sun W, Yang X, Wang J, et al. A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines. J Leukoc Biol. 2017;102:1271-1280 pubmed publisher
Geng S, Zhong Y, Zhou X, Zhao G, Xie X, Pei Y, et al. Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage. Front Immunol. 2017;8:663 pubmed publisher
Putz E, Mayfosh A, Kos K, Barkauskas D, Nakamura K, Town L, et al. NK cell heparanase controls tumor invasion and immune surveillance. J Clin Invest. 2017;127:2777-2788 pubmed publisher
CASTILLO G, Nishimoto Ashfield A, Jones C, Kabirov K, Zakharov A, Lyubimov A. Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury. PLoS ONE. 2017;12:e0171703 pubmed publisher
Ioannidis L, Nie C, Ly A, Ryg Cornejo V, Chiu C, Hansen D. Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease. J Immunol. 2016;196:1227-38 pubmed publisher
Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M. Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice. PLoS Pathog. 2015;11:e1005120 pubmed publisher
Clarner T, Janssen K, Nellessen L, Stangel M, Skripuletz T, Krauspe B, et al. CXCL10 triggers early microglial activation in the cuprizone model. J Immunol. 2015;194:3400-13 pubmed publisher
Cuenca A, Joiner D, Gentile L, Cuenca A, Wynn J, Kelly Scumpia K, et al. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015;194:1169-77 pubmed publisher
Krauthausen M, Kummer M, Zimmermann J, Reyes Irisarri E, Terwel D, Bulic B, et al. CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. J Clin Invest. 2015;125:365-78 pubmed publisher
Fujihara Y, Takato T, Hoshi K. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells. 2014;32:1208-19 pubmed publisher
Lacotte S, Decossas M, Le Coz C, Brun S, Muller S, Dumortier H. Early differentiated CD138(high) MHCII+ IgG+ plasma cells express CXCR3 and localize into inflamed kidneys of lupus mice. PLoS ONE. 2013;8:e58140 pubmed publisher
Kim H, Go H, Akira S, Chung D. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice. J Immunol. 2011;187:4007-17 pubmed publisher
Liu C, Luo D, Reynolds B, Meher G, Katritzky A, Lu B, et al. Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis. 2011;32:129-37 pubmed publisher
product information
brand :
R&D Systems
master code :
466-CR
SKU :
466-CR-010
product name :
Recombinant Mouse CXCL10/IP-10/CRG-2 Protein
unit size :
10 ug
description :
The Recombinant Mouse CXCL10/IP-10/CRG-2 Protein, CF from R&D Systems is derived from E. coli.
target :
CXCL10/IP-10/CRG-2
category :
Proteins and Enzymes
alt names :
C7, chemokine (C-X-C motif) ligand 10, crg-2, CRG2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
8.8 kDa
gene symbol :
Cxcl10
details of functionality :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR3. The ED50 for this effect is 0.05-0.3 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q548V9
source :
E. coli-derived Recombinant Mouse CXCL10/IP-10/CRG-2 Protein
USD :
269
Jul-22 :
291 USD
sizes available :
10 ug (also 50 ug)
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.