product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse PlGF-2 Protein
catalog :
465-PL-010
quantity :
10 ug (also 50 ug)
price :
373 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Verma M, Shimizu Motohashi Y, Asakura Y, Ennen J, Bosco J, Zhou Z, et al. Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy. PLoS Genet. 2019;15:e1008468 pubmed publisher
Pedrosa A, Bodrug N, Gómez Escudero J, Carter E, Reynolds L, Georgiou P, et al. Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861. Cancer Res. 2019;: pubmed publisher
Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, et al. Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration. Cell Rep. 2019;27:3152-3166.e7 pubmed publisher
Van Bergen T, Jonckx B, Moons L, Feyen J, Stalmans I. The Combination of PlGF Inhibition and MMC as a Novel Anti-Scarring Strategy for Glaucoma Filtration Surgery. Invest Ophthalmol Vis Sci. 2016;57:4347-55 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Jaba I, Zhuang Z, Li N, Jiang Y, Martin K, Sinusas A, et al. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013;123:1718-31 pubmed
Pitchford S, Lodie T, Rankin S. VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice. Blood. 2012;120:2787-95 pubmed publisher
Patel N, Sundaram N, Yang M, Madigan C, Kalra V, Malik P. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010;285:16713-22 pubmed publisher
Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161:1163-77 pubmed
Maynard S, Min J, Merchan J, Lim K, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-58 pubmed
Oura H, Bertoncini J, Velasco P, Brown L, Carmeliet P, Detmar M. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood. 2003;101:560-7 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
465-PL
SKU :
465-PL-010
product name :
Recombinant Mouse PlGF-2 Protein
description :
The Recombinant Mouse PlGF-2 Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse PlGF-2 Protein has been validated for the following applications: Binding Activity.
target :
PlGF-2
unit size :
10 ug (also 50 ug)
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
15-22 kDa, under reducing conditions.
theoretical molecular weight :
15.1 kDa (monomer)
gene symbol :
Pgf
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Mouse VEGFR1/Flt-1 Fc Chimera (Catalog # 7756-FL ) is immobilized at 2 µg/mL (100 µL/well), Recombinant Mouse PlGF 2 (Catalog # 465-PL) binds with an ED50 of 0.350-3.50 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q544A5
applications :
Binding Activity
product keywords :
465-PL, rmPlGF-2, mPlGF-2,, 465PL, cytokinegrowthfact, PlGF2, PlGF 2. PGF, PGFL
source :
Sf 21 (baculovirus)-derived Recombinant Mouse PlGF-2 Protein
USD :
365
USD 2025 :
373 USD
alt names :
OORS, PlGF2
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.