product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human VEGF 121 (aa 207-327) Protein
catalog :
4644-VS-010
quantity :
10 ug
price :
323 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Ma S, Mangala L, Hu W, Bayaktar E, Yokoi A, Hu W, et al. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Rep. 2021;36:109549 pubmed publisher
Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed publisher
Njau F, Shushakova N, Schenk H, Wulfmeyer V, Bollin R, Menne J, et al. Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice. PLoS ONE. 2020;15:e0218494 pubmed publisher
Uslu Ö, Herold J, Kanse S. VEGF-A-Cleavage by FSAP and Inhibition of Neo-Vascularization. Cells. 2019;8: pubmed publisher
Abou Faycal C, Gazzeri S, Eymin B. A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells. Sci Rep. 2019;9:336 pubmed publisher
Stephenson S, Care M, Fan I, Zougman A, Westhead D, Doody G, et al. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. J Immunol. 2019;202:1287-1300 pubmed publisher
Patel N, Able S, Allen D, Fokas E, Cornelissen B, Gleeson F, et al. Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab. EJNMMI Res. 2017;7:49 pubmed publisher
Kapur S, Silverman A, Ye A, Papo N, Jindal D, Blumenkranz M, et al. Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis. Bioeng Transl Med. 2017;2:81-91 pubmed publisher
Ahmadova Z, Yagublu V, Forg T, Hajiyeva Y, Jesenofsky R, Hafner M, et al. Fluorescent resonance energy transfer imaging of VEGFR dimerization. Anticancer Res. 2014;34:2123-33 pubmed
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
Esquibies A, Karihaloo A, Quaggin S, Bazzy Asaad A, Cantley L. Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway. Respir Res. 2014;15:32 pubmed publisher
Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I. Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. PLoS ONE. 2013;8:e56754 pubmed publisher
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed publisher
Rennel E, Varey A, Churchill A, Wheatley E, Stewart L, Mather S, et al. VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br J Cancer. 2009;101:1183-93 pubmed publisher
product information
brand :
R&D Systems
master code :
4644-VS
SKU :
4644-VS-010
product name :
Recombinant Human VEGF 121 (aa 207-327) Protein
description :
The Recombinant Human VEGF 121 (aa 207-327) Protein from R&D Systems is derived from E. coli. The Recombinant Human VEGF 121 (aa 207-327) Protein has been validated for the following applications: Bioactivity.
target :
VEGF
category :
Proteins and Enzymes
sizes available :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in HCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
14 kDa (monomer)
gene symbol :
VEGFA
details of functionality :
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al . (1990) Proc. Natl. Acad. Sci. USA 87 :1323. The ED50 for this effect is 1.00-8.00 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_001020541
applications :
Bioactivity
source :
E. coli-derived Recombinant Human VEGF 121 (aa 207-327) Protein
USD :
323
USD 2023 :
323 USD
alt names :
MVCD1, VAS, vascular endothelial growth factor A, Vascular permeability factor, Vasculotropin, VEGFA, VEGF-A, VEGFMGC70609, VPF, VPFvascular endothelial growth factor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.