Recombinant Human VEGF 121 (aa 207-327) Protein | R&D Systems 4644-VS-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human VEGF 121 (aa 207-327) Protein

catalog :

4644-VS-010

quantity :

10 ug

price :

344 USD

citations: 16

Reference
Tzuri N, Yegodayev K, Novoplansky O, Elkabets M, Aharoni A, Papo N. Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy. Sci Rep. 2023;13:11923 pubmed publisher
Ichiyama Y, Matsumoto R, Obata S, Sawada O, Saishin Y, Kakinoki M, et al. Assessment of mouse VEGF neutralization by ranibizumab and aflibercept. PLoS ONE. 2022;17:e0278951 pubmed publisher
Ma S, Mangala L, Hu W, Bayaktar E, Yokoi A, Hu W, et al. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Rep. 2021;36:109549 pubmed publisher
Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed publisher
Njau F, Shushakova N, Schenk H, Wulfmeyer V, Bollin R, Menne J, et al. Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice. PLoS ONE. 2020;15:e0218494 pubmed publisher
Uslu Ö, Herold J, Kanse S. VEGF-A-Cleavage by FSAP and Inhibition of Neo-Vascularization. Cells. 2019;8: pubmed publisher
Abou Faycal C, Gazzeri S, Eymin B. A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells. Sci Rep. 2019;9:336 pubmed publisher
Stephenson S, Care M, Fan I, Zougman A, Westhead D, Doody G, et al. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. J Immunol. 2019;202:1287-1300 pubmed publisher
Patel N, Able S, Allen D, Fokas E, Cornelissen B, Gleeson F, et al. Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab. EJNMMI Res. 2017;7:49 pubmed publisher
Kapur S, Silverman A, Ye A, Papo N, Jindal D, Blumenkranz M, et al. Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis. Bioeng Transl Med. 2017;2:81-91 pubmed publisher
Ahmadova Z, Yagublu V, Forg T, Hajiyeva Y, Jesenofsky R, Hafner M, et al. Fluorescent resonance energy transfer imaging of VEGFR dimerization. Anticancer Res. 2014;34:2123-33 pubmed
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
Esquibies A, Karihaloo A, Quaggin S, Bazzy Asaad A, Cantley L. Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway. Respir Res. 2014;15:32 pubmed publisher
Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I. Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. PLoS ONE. 2013;8:e56754 pubmed publisher
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed publisher
Rennel E, Varey A, Churchill A, Wheatley E, Stewart L, Mather S, et al. VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br J Cancer. 2009;101:1183-93 pubmed publisher

product information

master code :

4644-VS

SKU :

4644-VS-010

product name :

Recombinant Human VEGF 121 (aa 207-327) Protein

unit size :

10 ug

description :

The Recombinant Human VEGF 121 (aa 207-327) Protein from R&D Systems is derived from E. coli. The Recombinant Human VEGF 121 (aa 207-327) Protein has been validated for the following applications: Bioactivity.

target :

VEGF

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

14 kDa (monomer)

gene symbol :

VEGFA

details of functionality :

Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al . (1990) Proc. Natl. Acad. Sci. USA 87 :1323. The ED50 for this effect is 1.00-8.00 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_001020541

applications :

Bioactivity

source long :

E. coli -derived human VEGF protein Ala207-Arg327, with an N-terminal Met & Pro208-Arg327

source short :

E. coli

USD :

344 USD

alt names :

MVCD1, VAS, vascular endothelial growth factor A, Vascular permeability factor, Vasculotropin, VEGFA, VEGF-A, VEGFMGC70609, VPF, VPFvascular endothelial growth factor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.