| Reference |
|---|
De Luzy I, Law K, Moriarty N, Hunt C, Durnall J, Thompson L, et al. Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nat Commun. 2021;12:3275 pubmed publisher |
Padmanabhan Nair V, Liu H, Ciceri G, Jungverdorben J, Frishman G, Tchieu J, et al. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. Cell Stem Cell. 2021;28:1566-1581.e8 pubmed publisher |
Tao Y, Vermilyea S, Zammit M, Lu J, Olsen M, Metzger J, et al. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nat Med. 2021;27:632-639 pubmed publisher |
Piao J, Zabierowski S, Dubose B, Hill E, Navare M, Claros N, et al. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell Stem Cell. 2021;28:217-229.e7 pubmed publisher |
Kim J, Yin X, Jhaldiyal A, Khan M, Martin I, Xie Z, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. 2020;27:633-645.e7 pubmed publisher |
Aldaregia J, Errarte P, Olazagoitia Garmendia A, Gimeno M, Uriz J, Gershon T, et al. Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma. Cancers (Basel). 2020;12: pubmed publisher |
Kasiri S, Chen B, Wilson A, Reczek A, Mazambani S, Gadhvi J, et al. Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species. Oncogene. 2020;39:3258-3275 pubmed publisher |
Vermilyea S, Babinski A, Tran N, To S, Guthrie S, Kluss J, et al. In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets. Sci Rep. 2020;10:3447 pubmed publisher |
Wada Y, Kikuchi A, Kaga A, Shimizu N, Ito J, Onuma R, et al. Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice. PLoS Genet. 2020;16:e1008628 pubmed publisher |
Gantner C, De Luzy I, Kauhausen J, Moriarty N, Niclis J, Bye C, et al. Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease. Cell Stem Cell. 2020;26:511-526.e5 pubmed publisher |
Mahajani S, Raina A, Fokken C, Kügler S, Bahr M. Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors. Cell Death Dis. 2019;10:898 pubmed publisher |
Leitner D, Ramamoorthy M, Dejosez M, Zwaka T. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation. Stem Cell Res. 2019;41:101617 pubmed publisher |
De Luzy I, Niclis J, Gantner C, Kauhausen J, Hunt C, Ermine C, et al. Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease. J Neurosci. 2019;39:9521-9531 pubmed publisher |
Riessland M, Kolisnyk B, Kim T, Cheng J, Ni J, Pearson J, et al. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. 2019;25:514-530.e8 pubmed publisher |
Penas C, Maloof M, Stathias V, Long J, Tan S, Mier J, et al. Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis. Nat Commun. 2019;10:3028 pubmed publisher |
Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim K, Sun P, et al. hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. Cell Stem Cell. 2019;: pubmed publisher |
Grabow S, Kueh A, Ke F, Vanyai H, Sheikh B, Dengler M, et al. Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities. Cell Rep. 2018;24:3285-3295.e4 pubmed publisher |
Tasnim N, Thakur V, Chattopadhyay M, Joddar B. The Efficacy of Graphene Foams for Culturing Mesenchymal Stem Cells and Their Differentiation into Dopaminergic Neurons. Stem Cells Int. 2018;2018:3410168 pubmed publisher |
Everson J, Fink D, Chung H, Sun M, Lipinski R. Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics. BMC Genomics. 2018;19:497 pubmed publisher |
Wang B, Joo J, Mount R, Teubner B, Krenzer A, Ward A, et al. The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018;128:3319-3332 pubmed publisher |
Collo G, Cavalleri L, Zoli M, Maskos U, Ratti E, Merlo Pich E. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons. Front Pharmacol. 2018;9:572 pubmed publisher |
Wang Y, Zhu W, Wu M, Wu Y, Liu Z, Liang L, et al. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports. 2018;11:171-182 pubmed publisher |
Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi R, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018;2018:4196961 pubmed publisher |
Adil M, Schaffer D. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Curr Protoc Stem Cell Biol. 2018;44:2D.21.1-2D.21.17 pubmed publisher |
Niclis J, Gantner C, Hunt C, Kauhausen J, Durnall J, Haynes J, et al. A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells. Stem Cell Reports. 2017;9:868-882 pubmed publisher |
Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-?2 nuclear import system. PLoS Biol. 2017;15:e2002063 pubmed publisher |
Xiang Y, Tanaka Y, Patterson B, Kang Y, Govindaiah G, Roselaar N, et al. Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell. 2017;21:383-398.e7 pubmed publisher |
Baronchelli S, La Spada A, Ntai A, Barbieri A, Conforti P, Jotti G, et al. Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model. Mol Cell Neurosci. 2017;82:46-57 pubmed publisher |
Niclis J, Gantner C, Alsanie W, McDougall S, Bye C, Elefanty A, et al. Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Stem Cells Transl Med. 2017;6:937-948 pubmed publisher |
Liddelow S, Guttenplan K, Clarke L, Bennett F, Bohlen C, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481-487 pubmed publisher |
Heyne G, Everson J, Ansen Wilson L, Melberg C, Fink D, Parins K, et al. Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model. Dis Model Mech. 2016;9:1307-1315 pubmed |
Shackleford G, Shi X, Swanson K, Mahdi M, Gonzalez Gomez I, Asgharzadeh S, et al. BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS ONE. 2016;11:e0156907 pubmed publisher |
Cao J, Poss K. Explant culture of adult zebrafish hearts for epicardial regeneration studies. Nat Protoc. 2016;11:872-81 pubmed publisher |
Wang J, Cao J, Dickson A, Poss K. Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. Nature. 2015;522:226-230 pubmed publisher |
Shi Y, Chen J, Karner C, Long F. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A. 2015;112:4678-83 pubmed publisher |
Edri R, Yaffe Y, Ziller M, Mutukula N, Volkman R, David E, et al. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun. 2015;6:6500 pubmed publisher |
Aguila J, Blak A, van Arensbergen J, Sousa A, Vazquez N, Aduriz A, et al. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med. 2014;3:1032-42 pubmed publisher |
Peluso M, Campbell V, Harari J, Tibbitts T, Proctor J, Whitebread N, et al. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity. PLoS ONE. 2014;9:e90534 pubmed publisher |
Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, et al. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 2013;12:559-72 pubmed publisher |
Najm F, Lager A, Zaremba A, Wyatt K, Caprariello A, Factor D, et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013;31:426-33 pubmed publisher |
Ho L, Ali S, Al Jazrawe M, Kandel R, Wunder J, Alman B. Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. Oncogene. 2013;32:5388-96 pubmed publisher |
Garcia I, Crowther A, Gama V, Miller C, Miller C, Deshmukh M, et al. Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene. 2013;32:2304-14 pubmed publisher |
Krencik R, Weick J, Liu Y, Zhang Z, Zhang S. Specification of transplantable astroglial subtypes from human pluripotent stem cells. Nat Biotechnol. 2011;29:528-34 pubmed publisher |
Zeng H, Guo M, Martins Taylor K, Wang X, Zhang Z, Park J, et al. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS ONE. 2010;5:e11853 pubmed publisher |
Nolan Stevaux O, Lau J, Truitt M, Chu G, Hebrok M, Fernandez Zapico M, et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009;23:24-36 pubmed publisher |
Bastida M, Delgado M, Wang B, Fallon J, Fernandez Teran M, Ros M. Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Dev Dyn. 2004;231:148-60 pubmed |
