product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-28A/IFN-lambda 2 Protein
catalog :
4635-ML-025
quantity :
25 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Zoellner N, Coesfeld N, De Vos F, Denter J, Xu H, Zimmer E, et al. Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling. Front Microbiol. 2022;13:947169 pubmed publisher
Won J, Jo A, Gil C, Kim S, Shin H, Jik Kim H. Inhaled delivery of recombinant interferon-lambda restores allergic inflammation after development of asthma by controlling Th2- and Th17-cell-mediated immune responses. Int Immunopharmacol. 2022;112:109180 pubmed publisher
Jhala G, Krishnamurthy B, Brodnicki T, Ge T, Akazawa S, Selck C, et al. Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse. Cell Rep. 2022;39:110747 pubmed publisher
Fedoriw A, Shi L, O Brien S, Smitheman K, Wang Y, Hou J, et al. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses. Cancer Immunol Res. 2022;10:420-436 pubmed publisher
Ardanuy J, Scanlon K, Skerry C, Fuchs S, Carbonetti N. Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease. J Immunol. 2020;204:2192-2202 pubmed publisher
Liou A, Liao C, Chou S, Chang Y, Chang C, Shih C. Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. J Biomed Sci. 2019;26:93 pubmed publisher
Nguyen T, Smith B, Elgass K, Creed S, Cheung S, Tate M, et al. SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm. J Immunol. 2019;: pubmed publisher
Stier M, Goleniewska K, Cephus J, Newcomb D, Sherrill T, Boyd K, et al. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. J Immunol. 2017;199:510-519 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
4635-ML
SKU :
4635-ML-025
product name :
Recombinant Mouse IL-28A/IFN-lambda 2 Protein
Description :
The Recombinant Mouse IL-28A/IFN-lambda 2 Protein from R&D Systems is derived from NS0. The Recombinant Mouse IL-28A/IFN-lambda 2 Protein has been validated for the following applications: Bioactivity.
target :
IL-28A/IFN-lambda 2
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
25 kDa and 30 kDa, reducing conditions
theoretical molecular weight :
20.5 kDa
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 0.0800-0.800 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_001019844
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse IL-28A/IFN-lambda 2 Protein
USD :
423 USD
alt names :
interleukin-28A, IFN-lambda 2, IL28A, IL-28A, interferon, lambda 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.