product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein
catalog :
462-TR-010
quantity :
10 ug
price :
388 USD
more info or order :
citations: 81
Reference
Xu Q, Zhan P, Li X, Mo F, Xu H, Liu Y, et al. Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment. J Cell Mol Med. 2021;25:10126-10139 pubmed publisher
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Xiao L, Zhong M, Huang Y, Zhu J, Tang W, Li D, et al. Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways. Aging (Albany NY). 2020;12:21706-21729 pubmed publisher
Rocha A, Bighetti Trevisan R, Duffles L, de Arruda J, Taira T, Assis B, et al. Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts. Thromb Res. 2020;186:45-53 pubmed publisher
Zhang Y, Cui Y, Wang L, Han J. Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3. Cell Signal. 2020;67:109505 pubmed publisher
Hu J, Li X, Chen Y, Han X, Li L, Yang Z, et al. The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-κB and CD9/gp130/STAT3 signalling pathway. J Cell Mol Med. 2020;24:1893-1905 pubmed publisher
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Quach D, Parameswaran N, McCabe L, Britton R. Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation. Bone Rep. 2019;11:100227 pubmed publisher
Guo R, Kim S, Choi C, Na C, Kang B, Kim Y. Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis. BMC Complement Altern Med. 2019;19:319 pubmed publisher
Park H, Gholam Zadeh M, Suh J, Choi H. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss. Oxid Med Cell Longev. 2019;2019:8982147 pubmed publisher
Wang J, Chen G, Zhang Q, Zhao F, Yu X, Ma X, et al. Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice. Front Pharmacol. 2019;10:1188 pubmed publisher
Park S, Choi E, Suh K, Kim H, Chin S, Rhee S, et al. Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro. J Korean Med Sci. 2019;34:e267 pubmed publisher
Wu R, Lian W, Chen Y, Kuo C, Ke H, Hsieh C, et al. MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis. Int J Mol Sci. 2019;20: pubmed publisher
Wang Y, Xie J, Ai Z, Su J. Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis. Int J Nanomedicine. 2019;14:7839-7849 pubmed publisher
Handa K, Kiyohara S, Yamakawa T, Ishikawa K, Hosonuma M, Sakai N, et al. Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson's disease model mice. Sci Rep. 2019;9:13768 pubmed publisher
Meng J, Zhou C, Zhang W, Wang W, He B, Hu B, et al. Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-κB and Akt signalling. J Cell Mol Med. 2019;23:6730-6743 pubmed publisher
Yang Y, Xie J, Wang D, Kim J, Tai P, Gravallese E, et al. Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis. Nat Commun. 2019;10:2958 pubmed publisher
Nair S, Strohecker A, Persaud A, Bissa B, Muruganandan S, McElroy C, et al. Adult stem cell deficits drive Slc29a3 disorders in mice. Nat Commun. 2019;10:2943 pubmed publisher
Yuan Q, Gao F, Yao Y, Cai P, Zhang X, Yuan J, et al. Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway. Theranostics. 2019;9:1825-1836 pubmed publisher
Adapala N, Root S, Lorenzo J, AGUILA H, Sanjay A. PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration. Bone Rep. 2019;10:100203 pubmed publisher
Putnam N, Fulbright L, Curry J, Ford C, Petronglo J, Hendrix A, et al. MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis. PLoS Pathog. 2019;15:e1007744 pubmed publisher
Sun Q, Zhang B, Zhu W, Wei W, Ma J, Tay F. A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation. J Dent. 2019;82:91-97 pubmed publisher
Broeren M, Di Ceglie I, Bennink M, van Lent P, van den Berg W, Koenders M, et al. Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation. Peerj. 2018;6:e4771 pubmed publisher
Di Ceglie I, Ascone G, Cremers N, Sloetjes A, Walgreen B, Vogl T, et al. Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis. Arthritis Res Ther. 2018;20:80 pubmed publisher
Quan H, Liang M, Li N, Dou C, Liu C, Bai Y, et al. LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells. Cell Physiol Biochem. 2018;46:401-417 pubmed publisher
Hwang Y, Kim K, Kim S, Mun S, Hong S, Son Y, et al. Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo. Int J Mol Sci. 2018;19: pubmed publisher
Orriss I, Lanham S, Savery D, Greene N, Stanier P, Oreffo R, et al. Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. Sci Rep. 2018;8:3325 pubmed publisher
Ma Y, Yang H, Huang J. Icariin ameliorates dexamethasone?induced bone deterioration in an experimental mouse model via activation of microRNA?186 inhibition of cathepsin K. Mol Med Rep. 2018;17:1633-1641 pubmed publisher
Grössinger E, Kang M, Bouchareychas L, Sarin R, Haudenschild D, Borodinsky L, et al. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018;200:749-757 pubmed publisher
Lombardi M, Gillieron C, Berkelaar M, Gabay C. Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. PLoS ONE. 2017;12:e0185426 pubmed publisher
Blixt N, Faulkner B, Astleford K, Lelich R, Schering J, Spencer E, et al. Class II and IV HDACs function as inhibitors of osteoclast differentiation. PLoS ONE. 2017;12:e0185441 pubmed publisher
Kindstedt E, Holm C, Sulniute R, Martinez Carrasco I, Lundmark R, Lundberg P. CCL11, a novel mediator of inflammatory bone resorption. Sci Rep. 2017;7:5334 pubmed publisher
Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed publisher
Colaianni G, Mongelli T, Cuscito C, Pignataro P, Lippo L, Spiro G, et al. Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice. Sci Rep. 2017;7:2811 pubmed publisher
Zhang J, Wang Z, Wu A, Nie J, Pei H, Hu W, et al. Differences in responses to X-ray exposure between osteoclast and osteoblast cells. J Radiat Res. 2017;58:791-802 pubmed publisher
Zhang L, Lv Y, Xian G, Lin Y. 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p. Biochem Biophys Res Commun. 2017;485:736-741 pubmed publisher
Zhou F, Shen Y, Liu B, Chen X, Wan L, Peng D. Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro. Biochem Biophys Res Commun. 2017;484:820-826 pubmed publisher
Eger M, Sterer N, Liron T, Kohavi D, Gabet Y. Scaling of titanium implants entrains inflammation-induced osteolysis. Sci Rep. 2017;7:39612 pubmed publisher
Hu X, Ping Z, Gan M, Tao Y, Wang L, Shi J, et al. Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway. Acta Biomater. 2017;48:479-488 pubmed publisher
Kim H, Ohk B, Yoon H, Kang W, Seong S, Kim S, et al. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts. Cell Signal. 2017;29:226-232 pubmed publisher
Yu H, Herbert B, Valerio M, Yarborough L, Hsu L, Argraves K. FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. Lipids Health Dis. 2015;14:66 pubmed publisher
Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U. Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem. 2015;290:20147-58 pubmed publisher
Maeda A, Ono M, Holmbeck K, Li L, Kilts T, Kram V, et al. WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem. 2015;290:14004-18 pubmed publisher
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, et al. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem. 2015;290:9377-86 pubmed publisher
Matsushita M, Ozaki Y, Hasegawa Y, Terada F, Tabata N, Shiheido H, et al. A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts. PLoS ONE. 2015;10:e0116135 pubmed publisher
Purdue P, Crotti T, Shen Z, Swantek J, Li J, Hill J, et al. Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate. Sci Rep. 2014;4:7595 pubmed publisher
Jeganathan S, Fiorino C, Naik U, Sun H, Harrison R. Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli. PLoS ONE. 2014;9:e104498 pubmed publisher
Krzeszinski J, Wei W, Huynh H, Jin Z, Wang X, Chang T, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature. 2014;512:431-5 pubmed publisher
Isaac J, Erthal J, Gordon J, Duverger O, Sun H, Lichtler A, et al. DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ. 2014;21:1365-76 pubmed publisher
Iyer S, Viernes D, Chisholm J, Margulies B, Kerr W. SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis. Stem Cells Dev. 2014;23:2336-51 pubmed publisher
Ke K, Sul O, Choi E, Safdar A, Kim E, Choi H. Reactive oxygen species induce the association of SHP-1 with c-Src and the oxidation of both to enhance osteoclast survival. Am J Physiol Endocrinol Metab. 2014;307:E61-70 pubmed publisher
Bartell S, Kim H, Ambrogini E, Han L, Iyer S, Serra Ucer S, et al. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014;5:3773 pubmed publisher
Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, et al. Effects of the peroxisome proliferator-activated receptor (PPAR)-δ agonist GW501516 on bone and muscle in ovariectomized rats. Endocrinology. 2014;155:2178-89 pubmed publisher
Sharma R, Callaway D, Vanegas D, Bendele M, Lopez Cruzan M, Horn D, et al. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS ONE. 2014;9:e93696 pubmed publisher
Yeon J, Kim K, Choi S, Moon S, Park Y, Ryu B, et al. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLC?-independent Ca2+ oscillation. PLoS ONE. 2014;9:e88974 pubmed publisher
Chiou W, Huang Y, Liu Y. (+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation. PLoS ONE. 2014;9:e89159 pubmed publisher
Gwyer Findlay E, Danks L, Madden J, Cavanagh M, McNamee K, McCann F, et al. OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A. 2014;111:2289-94 pubmed publisher
Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, et al. Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res. 2014;29:1431-45 pubmed publisher
Yao C, Yao G, Sun B, Zhang C, Tommasini S, Insogna K. The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. J Biol Chem. 2014;289:6775-90 pubmed publisher
Rementer C, Wu M, Buranaphatthana W, Yang H, Scatena M, Giachelli C. An inducible, ligand-independent receptor activator of NF-?B gene to control osteoclast differentiation from monocytic precursors. PLoS ONE. 2013;8:e84465 pubmed publisher
Biosse Duplan M, Zalli D, Stephens S, Zenger S, Neff L, Oelkers J, et al. Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src. Mol Cell Biol. 2014;34:16-29 pubmed publisher
Kim H, Yoon K, Yoon H, Hong J, Lee M, Lee I, et al. Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-κB activity and c-Fos induction and prevents inflammatory bone loss in mice. J Leukoc Biol. 2013;94:99-107 pubmed publisher
Tanaka H, Tanabe N, Kawato T, Nakai K, Kariya T, Matsumoto S, et al. Nicotine affects bone resorption and suppresses the expression of cathepsin K, MMP-9 and vacuolar-type H(+)-ATPase d2 and actin organization in osteoclasts. PLoS ONE. 2013;8:e59402 pubmed publisher
Han X, Lin X, Yu X, Lin J, Kawai T, Larosa K, et al. Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-κB ligand. Infect Immun. 2013;81:1502-9 pubmed publisher
Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, et al. Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab. 2013;304:E703-10 pubmed publisher
Edwards J, Perrien D, Fleming N, Nyman J, Ono K, Connelly L, et al. Silent information regulator (Sir)T1 inhibits NF-?B signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2013;28:960-9 pubmed publisher
Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, et al. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. J Bone Miner Res. 2013;28:936-47 pubmed publisher
Ma J, Chen W, Zhang L, Tucker B, Zhu G, Sasaki H, et al. RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun. 2013;81:1021-30 pubmed
Charles J, Hsu L, Niemi E, Weiss A, Aliprantis A, Nakamura M. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012;122:4592-605 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Shanmugarajan S, Beeson C, Reddy S. Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology. 2010;151:4389-99 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Wang L, Zhao R, Shi X, Wei T, Halloran B, Clark D, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 2009;45:309-20 pubmed publisher
Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal R, Hidaka C. Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone. J Bone Miner Res. 2009;24:1598-607 pubmed publisher
Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, et al. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem. 2009;284:14637-44 pubmed publisher
Walker E, McGregor N, Poulton I, Pompolo S, Allan E, Quinn J, et al. Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J Bone Miner Res. 2008;23:2025-32 pubmed publisher
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
Jia D, O Brien C, Stewart S, Manolagas S, Weinstein R. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology. 2006;147:5592-9 pubmed
Lubberts E, van den Bersselaar L, Oppers Walgreen B, Schwarzenberger P, Coenen de Roo C, Kolls J, et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J Immunol. 2003;170:2655-62 pubmed
image
image 1 :
R&D Systems 462-TR-010 image 1
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein Bioactivity
product information
brand :
R&D Systems
master code :
462-TR
SKU :
462-TR-010
product name :
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein
unit size :
10 ug
description :
The Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein, CF has been validated for the following applications: Bioactivity.
target :
TRANCE/TNFSF11/RANK L
category :
Proteins and Enzymes
alt names :
CD254, CD254 antigen, ODF, OPGL, OPGLOPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK L, RANKL, RANKLreceptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCEODFhRANKL2, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand superfamily member 11
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.
observed molecular weight :
36 kDa, reducing conditions
theoretical molecular weight :
28 kDa
gene symbol :
Tnfsf11
details of functionality :
Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 5-15 ng/mL in the presence of 2.5 µg/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ). An E. coli -expressed Recombinant Mouse (rm) TRANCE (aa 158-317) (Catalog # 462-TEC ) is also available. The ED50 for the E. coli -expressed rmTRANCE is 0.5-2 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O35235
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein
USD :
359
Jul-22 :
388 USD
sizes available :
10 ug
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.