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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein
catalog :
461-SH-025
quantity :
25 ug
price :
340 USD
more info or order :
citations: 35
Reference
Gao F, Klinedinst D, Fernandez F, Cheng B, Savonenko A, Devenney B, et al. Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates. Acta Neuropathol Commun. 2021;9:137 pubmed publisher
Zhang D, Huang J, Wang F, Ding H, Cui Y, Yang Y, et al. BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions. Cell Death Dis. 2021;12:495 pubmed publisher
Song K, Qing Y, Guo Q, Peden E, Chen C, Mitch W, et al. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease. JCI Insight. 2020;5: pubmed publisher
Petroni M, Sahún Roncero M, Ramponi V, Fabretti F, Nicolis di Robilant V, Moretti M, et al. SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors. Sci Rep. 2019;9:19623 pubmed publisher
Matjusaitis M, Wagstaff L, Martella A, Baranowski B, Blin C, Gogolok S, et al. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors. Stem Cell Reports. 2019;13:1053-1067 pubmed publisher
Petty A, Li A, Wang X, Dai R, Heyman B, Hsu D, et al. Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment. J Clin Invest. 2019;129:5151-5162 pubmed publisher
Yuan X, Liu M, Cao X, Yang S. Ciliary IFT80 regulates dental pulp stem cells differentiation by FGF/FGFR1 and Hh/BMP2 signaling. Int J Biol Sci. 2019;15:2087-2099 pubmed publisher
Xu C, Zou C, Hussain M, Shi W, Shao Y, Jiang Z, et al. High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia. Mucosal Immunol. 2018;11:1306-1315 pubmed publisher
Gao B, Ajima R, Yang W, Li C, Song H, Anderson M, et al. Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development. 2018;145: pubmed publisher
Gu D, Wang S, Zhang S, Zhang P, Zhou G. Directed transdifferentiation of Müller glial cells to photoreceptors using the sonic hedgehog signaling pathway agonist purmorphamine. Mol Med Rep. 2017;16:7993-8002 pubmed publisher
Solanki A, Lau C, Saldana J, Ross S, Crompton T. The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh. J Exp Med. 2017;214:2041-2058 pubmed publisher
Lan T, Kisseleva T, Brenner D. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS ONE. 2015;10:e0129743 pubmed publisher
Chàvez M, Ena S, van Sande J, de Kerchove d Exaerde A, Schurmans S, Schiffmann S. Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. Dev Cell. 2015;34:338-50 pubmed publisher
Yuan X, Yang S. Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation. PLoS ONE. 2015;10:e0130618 pubmed publisher
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher
Takenaka Ninagawa N, Kawabata Y, Watanabe S, Nagata K, Torihashi S. Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome. PLoS ONE. 2014;9:e104462 pubmed publisher
Rozycki M, Lodyga M, Lam J, Miranda M, Fatyol K, Speight P, et al. The fate of the primary cilium during myofibroblast transition. Mol Biol Cell. 2014;25:643-57 pubmed publisher
Au E, Ahmed T, Karayannis T, Biswas S, Gan L, Fishell G. A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells. Neuron. 2013;80:1145-58 pubmed publisher
Engevik A, Feng R, Yang L, Zavros Y. The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology. 2013;154:4627-39 pubmed publisher
Liu X, Chopp M, Wang X, Zhang L, Hozeska Solgot A, Tang T, et al. MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem. 2013;288:12478-88 pubmed publisher
Belgacem Y, Borodinsky L. Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci U S A. 2011;108:4482-7 pubmed publisher
Del Debbio C, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I. Notch and Wnt signaling mediated rod photoreceptor regeneration by Müller cells in adult mammalian retina. PLoS ONE. 2010;5:e12425 pubmed publisher
Lipinski R, Bijlsma M, Gipp J, Podhaizer D, Bushman W. Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines. BMC Cell Biol. 2008;9:49 pubmed publisher
Wan J, Zheng H, Xiao H, She Z, Zhou G. Sonic hedgehog promotes stem-cell potential of Müller glia in the mammalian retina. Biochem Biophys Res Commun. 2007;363:347-54 pubmed
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
Podlasek C, Meroz C, Tang Y, McKenna K, McVary K. Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod. 2007;76:19-28 pubmed
Tiecke E, Bangs F, Blaschke R, Farrell E, Rappold G, Tickle C. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev Biol. 2006;298:585-96 pubmed
Brito J, Teillet M, Le Douarin N. An early role for sonic hedgehog from foregut endoderm in jaw development: ensuring neural crest cell survival. Proc Natl Acad Sci U S A. 2006;103:11607-12 pubmed
Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, et al. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death. J Neurochem. 2006;98:45-56 pubmed
Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, et al. Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells. FASEB J. 2005;19:1860-2 pubmed
Perrier A, Tabar V, Barberi T, Rubio M, Bruses J, Topf N, et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A. 2004;101:12543-8 pubmed
Abzhanov A, Tabin C. Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev Biol. 2004;273:134-48 pubmed
Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
Viti J, Gulacsi A, Lillien L. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci. 2003;23:5919-27 pubmed
Mistretta C, Liu H, Gaffield W, Maccallum D. Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium. Dev Biol. 2003;254:1-18 pubmed
image
image 1 :
R&D Systems 461-SH-025 image 1
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein Bioactivity
product information
brand :
R&D Systems
master code :
461-SH
SKU :
461-SH-025
product name :
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein
description :
The Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein from R&D Systems is derived from E. coli. The Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein has been validated for the following applications: Bioactivity.
target :
Sonic Hedgehog/Shh
category :
Proteins and Enzymes
sizes available :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS, Trehalose and with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
20 kDa
gene symbol :
Shh
details of functionality :
Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al . (1997) Biochem. Biophys. Res. Commun. 237 :465. The ED50 for this effect is 0.6-3 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62226
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein
USD :
334
USD 2023 :
340 USD
alt names :
HHG1, HHG-1, HLP3, HPE3, MCOPCB5, MCOPCB5sonic hedgehog (Drosophila) homolog, Shh, ShhNC, SMMCI, SMMCIsonic hedgehog homolog (Drosophila), sonic hedgehog, sonic hedgehog homolog, sonic hedgehog protein, TPT, TPTPS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.