This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein, CF
catalog :
461-SH-025/CF
quantity :
25 ug
price :
373 USD
citations: 36
| Reference |
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Wan J, Zheng H, Xiao H, She Z, Zhou G. Sonic hedgehog promotes stem-cell potential of Müller glia in the mammalian retina. Biochem Biophys Res Commun. 2007;363:347-54 pubmed
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Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
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Podlasek C, Meroz C, Tang Y, McKenna K, McVary K. Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod. 2007;76:19-28 pubmed
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Tiecke E, Bangs F, Blaschke R, Farrell E, Rappold G, Tickle C. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev Biol. 2006;298:585-96 pubmed
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Brito J, Teillet M, Le Douarin N. An early role for sonic hedgehog from foregut endoderm in jaw development: ensuring neural crest cell survival. Proc Natl Acad Sci U S A. 2006;103:11607-12 pubmed
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Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, et al. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death. J Neurochem. 2006;98:45-56 pubmed
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Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, et al. Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells. FASEB J. 2005;19:1860-2 pubmed
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Perrier A, Tabar V, Barberi T, Rubio M, Bruses J, Topf N, et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A. 2004;101:12543-8 pubmed
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Abzhanov A, Tabin C. Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev Biol. 2004;273:134-48 pubmed
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Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
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Viti J, Gulacsi A, Lillien L. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci. 2003;23:5919-27 pubmed
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Mistretta C, Liu H, Gaffield W, Maccallum D. Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium. Dev Biol. 2003;254:1-18 pubmed
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product information
master code :
461-SH/CF
SKU :
461-SH-025/CF
product name :
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein, CF
unit size :
25 ug
description :
The Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein, CF has been validated for the following applications: Bioactivity.
target :
Sonic Hedgehog/Shh
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
20 kDa
gene symbol :
Shh
details of functionality :
Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al . (1997) Biochem. Biophys. Res. Commun. 237 :465. The ED50 for this effect is 0.6-3 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus Protein Bioactivity
accessionNumbers :
Q62226
applications :
Bioactivity
source long :
E. coli -derived mouse Sonic Hedgehog/Shh protein Cys25-Gly198, with a C-terminal 6-His tag
source short :
E. coli
USD :
373 USD
alt names :
HHG1, HHG-1, HLP3, HPE3, MCOPCB5, MCOPCB5sonic hedgehog (Drosophila) homolog, Shh, ShhNC, SMMCI, SMMCIsonic hedgehog homolog (Drosophila), sonic hedgehog, sonic hedgehog homolog, sonic hedgehog protein, TPT, TPTPS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information

R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.
questions and comments
