Recombinant Mouse CX3CL1/Fractalkine (Chemokine Domain) | R&D Systems 458-MF-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CX3CL1/Fractalkine (Chemokine Domain)

catalog :

458-MF-025

quantity :

25 ug

price :

432 USD

citations: 8

Reference
Banerjee J, Dorfman M, Fasnacht R, Douglass J, Wyse Jackson A, Barria A, et al. CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding. Int J Mol Sci. 2022;23: pubmed publisher
Martinez M, Capella Gonzalez C, Huey D, Peeples M, MCCARTY D, Niewiesk S. Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats. PLoS ONE. 2021;16:e0246770 pubmed publisher
Yang T, Guo L, Chen L, Li J, Li Q, Pi Y, et al. A novel role of FKN/CX3CR1 in promoting osteogenic transformation of VSMCs and atherosclerotic calcification. Cell Calcium. 2020;91:102265 pubmed publisher
O Sullivan S, Dev K. The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices. J Neuroinflammation. 2017;14:159 pubmed publisher
Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
Fuller A, Van Eldik L. MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol. 2008;3:246-56 pubmed publisher
Yang X, Mattagajasingh S, Su S, Chen G, Cai Z, Fox Talbot K, et al. Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway. Circ Res. 2007;101:1001-8 pubmed
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed

product information

master code :

458-MF

SKU :

458-MF-025

product name :

Recombinant Mouse CX3CL1/Fractalkine (Chemokine Domain)

unit size :

25 ug

description :

The Recombinant Mouse CX3CL1/Fractalkine (Chemokine Domain) from R&D Systems is derived from E. coli. The Recombinant Mouse CX3CL1/Fractalkine (Chemokine Domain) has been validated for the following applications: Bioactivity.

target :

CX3CL1/Fractalkine

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

9.5 kDa

gene symbol :

Cx3cl1

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CX3CR1. The ED50 for this effect is 10-50 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O35188

applications :

Bioactivity

source long :

E. coli -derived mouse CX3CL1/Fractalkine protein Leu22-Lys105

source short :

E. coli

USD :

432 USD

alt names :

ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.