Recombinant Mouse CXCL1/KC Protein, CF | R&D Systems 453-KC-050/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CXCL1/KC Protein, CF

catalog :

453-KC-050/CF

quantity :

50 ug

price :

459 USD

citations: 51

Reference
Cai S, Paudel S, Jin L, Ghimire L, Taylor C, Wakamatsu N, et al. NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis. Mucosal Immunol. 2021;14:574-584 pubmed publisher
Vagima Y, Gur D, Erez N, Achdout H, Aftalion M, Levy Y, et al. Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments. Sci Rep. 2020;10:19116 pubmed publisher
Lin W, Gowdy K, Madenspacher J, Zemans R, Yamamoto K, Lyons Cohen M, et al. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020;130:157-170 pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
Brennan F, Jogia T, Gillespie E, Blomster L, Li X, Nowlan B, et al. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight. 2019;4: pubmed publisher
Luissint A, Williams H, Kim W, Flemming S, Azcutia V, Hilgarth R, et al. Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice. Mucosal Immunol. 2019;12:668-678 pubmed publisher
Pádua T, Torres N, Candea A, Costa M, Silva J, Silva Filho J, et al. Therapeutic effect of Lipoxin A4 in malaria-induced acute lung injury. J Leukoc Biol. 2018;103:657-670 pubmed publisher
García Prieto J, Villena Gutiérrez R, Gomez M, Bernardo E, Pun García A, Garcia Lunar I, et al. Neutrophil stunning by metoprolol reduces infarct size. Nat Commun. 2017;8:14780 pubmed publisher
Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, et al. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. 2017;47:704-712 pubmed publisher
Latasiewicz J, Artz A, Jing D, Blanco M, Currie S, Avila M, et al. HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1. J Leukoc Biol. 2017;101:1133-1142 pubmed publisher
Busch C, Hendrikx T, Weismann D, Jäckel S, Walenbergh S, Rendeiro A, et al. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017;65:1181-1195 pubmed publisher
Thanabalasuriar A, Neupane A, Wang J, Krummel M, Kubes P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016;16:3260-3272 pubmed publisher
Kouwenberg M, Jacobs C, van der Vlag J, Hilbrands L. Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype. PLoS ONE. 2016;11:e0159986 pubmed publisher
Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R. Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow. J Immunol. 2015;195:3880-9 pubmed publisher
Fujihara Y, Takato T, Hoshi K. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells. 2014;32:1208-19 pubmed publisher
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
Aeffner F, Davis I. Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice. PLoS ONE. 2012;7:e46660 pubmed publisher
Reichel C, Puhr Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, et al. C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood. 2012;120:880-90 pubmed publisher
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
Moalli F, Paroni M, Véliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, et al. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol. 2011;186:5425-34 pubmed publisher
Jang J, Hod E, Spitalnik S, Frenette P. CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J Clin Invest. 2011;121:1397-401 pubmed publisher
Russo R, Garcia C, Barcelos L, Rachid M, Guabiraba R, Roffe E, et al. Phosphoinositide 3-kinase ? plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J Leukoc Biol. 2011;89:269-82 pubmed publisher
Petri B, Broermann A, Li H, Khandoga A, Zarbock A, Krombach F, et al. von Willebrand factor promotes leukocyte extravasation. Blood. 2010;116:4712-9 pubmed publisher
Massena S, Christoffersson G, Hjertström E, Zcharia E, Vlodavsky I, Ausmees N, et al. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood. 2010;116:1924-31 pubmed publisher
Jimenez F, Quinones M, Martinez H, Estrada C, Clark K, Garavito E, et al. CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B. J Immunol. 2010;184:5571-81 pubmed publisher
Deban L, Russo R, Sironi M, Moalli F, Scanziani M, Zambelli V, et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol. 2010;11:328-34 pubmed publisher
Traylor Z, Yu E, Davis I. Respiratory syncytial virus induces airway insensitivity to beta-agonists in BALB/c mice. Am J Physiol Lung Cell Mol Physiol. 2010;298:L437-45 pubmed publisher
Schneider D, Lindsay J, Zhou Y, Molina J, Blackburn M. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J. 2010;24:70-80 pubmed publisher
Wilson R, Whitehead G, Nakano H, Free M, Kolls J, Cook D. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009;180:720-30 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Wieland C, van der Windt G, Florquin S, McKenzie A, van der Poll T. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 2009;11:524-30 pubmed publisher
Koenen R, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, et al. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood. 2009;113:4799-809 pubmed publisher
Chen S, Cheng D, Williams B, Sherrill T, Han W, Chont M, et al. The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol. 2008;153:420-8 pubmed publisher
Kerfoot S, Andonegui G, Bonder C, Liu L. Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo. Am J Physiol Heart Circ Physiol. 2008;294:H2524-34 pubmed publisher
Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch K, et al. Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J Immunol. 2008;180:3305-12 pubmed
Kagari T, Tanaka D, Doi H, Iwakura Y, Shimozato T. Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice. Eur J Immunol. 2007;37:2753-63 pubmed
Liu L, Puri K, Penninger J, Kubes P. Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 2007;110:1191-8 pubmed
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, et al. High pressure promotes monocyte adhesion to the vascular wall. Circ Res. 2007;100:1226-33 pubmed
Zemann B, Urtz N, Reuschel R, Mechtcheriakova D, Bornancin F, Badegruber R, et al. Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol Lett. 2007;109:56-63 pubmed
Fan X, Patera A, Pong Kennedy A, Deno G, Gonsiorek W, Manfra D, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J Biol Chem. 2007;282:11658-66 pubmed
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, et al. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J Immunol. 2006;177:8650-7 pubmed
Penido C, Conte F, Chagas M, Rodrigues C, Pereira J, Henriques M. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm Res. 2006;55:457-64 pubmed
Hajjar A, Harvey M, Shaffer S, Goodlett D, Sjostedt A, Edebro H, et al. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun. 2006;74:6730-8 pubmed
Ramos C, Fernandes K, Canetti C, Teixeira M, Silva J, Cunha F. Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur J Immunol. 2006;36:2025-34 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
Wislez M, Fujimoto N, Izzo J, Hanna A, Cody D, Langley R, et al. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res. 2006;66:4198-207 pubmed
Mihara K, Smit M, Krajnc Franken M, Gossen J, Rooseboom M, Dokter W. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur J Immunol. 2005;35:2573-82 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Venturi G, Tu L, Kadono T, Khan A, Fujimoto Y, Oshel P, et al. Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003;19:713-24 pubmed

product information

brand :

R&D Systems

master code :

453-KC/CF

SKU :

453-KC-050/CF

product name :

Recombinant Mouse CXCL1/KC Protein, CF

description :

The Recombinant Mouse CXCL1/KC Protein, CF from R&D Systems is derived from E. coli.

target :

CXCL1/GRO alpha/KC/CINC-1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

theoretical molecular weight :

8 kDa

gene symbol :

Cxcl1

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 3-15 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P12850

source :

The Recombinant Mouse CXCL1/KC Protein, CF from R&D Systems is derived from E. coli -derived mouse CXCL1/GRO alpha/KC/CINC-1 protein Arg20-Lys96.

USD 2021 :

439

USD 2022 :

459 USD

alt name :

CINC1, CINC-1, FSP, GRO alpha, GRO1, GROa, KC, MGSA, MGSA-a, MGSA-alpha, NAP-3, SCYB1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.