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company name :
R&D Systems
product type :
other
product name :
HT PARP In Vivo Pharmacodynamic Assay II Kit
catalog :
4520B-096-K
quantity :
1 Kit
price :
1418 USD
more info or order :
citations: 21
Reference
Alvarez Y, Mancebo C, Alonso S, Montero O, Fern xe1 ndez N, S xe1 nchez Crespo M. Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells. Redox Biol. 2024;73:103187 pubmed publisher
Kumar M, Kumar Singh P, Choudhary S, Silakari O. Hydantoin based dual inhibitors of ALR2 and PARP-1: Design, synthesis, in-vitro and in-vivo evaluation. Bioorg Chem. 2022;129:106108 pubmed publisher
Koczor C, Haider A, Saville K, Li J, Andrews J, Beiser A, et al. Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens. Cancers (Basel). 2022;14: pubmed publisher
Morgan S, Tanizawa H, Caruso L, Hulse M, Kossenkov A, Madzo J, et al. The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity. Nat Commun. 2022;13:187 pubmed publisher
Ma Y, Chen P, Drisko J, Khabele D, Godwin A, Chen Q. Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer. Oncol Lett. 2020;19:2629-2638 pubmed publisher
Zhang D, Baldwin P, Leal A, Carapellucci S, Sridhar S, Liby K. A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics. 2019;9:6224-6238 pubmed publisher
Riches L, Trinidad A, Hughes G, Jones G, Hughes A, Thomason A, et al. Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically. Mol Cancer Ther. 2020;19:13-25 pubmed publisher
Matveeva E, Mathbout L, Fondufe Mittendorf Y. PARP1 is a versatile factor in the regulation of mRNA stability and decay. Sci Rep. 2019;9:3722 pubmed publisher
Matveeva E, Al Tinawi Q, Rouchka E, Fondufe Mittendorf Y. Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing. Epigenetics Chromatin. 2019;12:15 pubmed publisher
Sun K, Mikule K, Wang Z, Poon G, Vaidyanathan A, Smith G, et al. A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models. Oncotarget. 2018;9:37080-37096 pubmed publisher
Martin K, Lupey L, Tempera I. Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. J Virol. 2016;90:8520-30 pubmed publisher
Rodler E, Kurland B, Griffin M, Gralow J, Porter P, Yeh R, et al. Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer. Clin Cancer Res. 2016;22:2855-64 pubmed publisher
Martin K, Cesaroni M, Denny M, Lupey L, Tempera I. Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol. 2015;35:3934-44 pubmed publisher
Karginova O, Siegel M, Van Swearingen A, Deal A, Adamo B, Sambade M, et al. Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Mol Cancer Ther. 2015;14:920-30 pubmed publisher
Lee J, Hays J, Annunziata C, Noonan A, Minasian L, Zujewski J, et al. Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analyses. J Natl Cancer Inst. 2014;106:dju089 pubmed publisher
Kinders R, Ferry Galow K, Wang L, Srivastava A, Ji J, Parchment R. Implementation of validated pharmacodynamic assays in multiple laboratories: challenges, successes, and limitations. Clin Cancer Res. 2014;20:2578-86 pubmed publisher
Horton J, Stefanick D, Prasad R, Gassman N, Kedar P, Wilson S. Base excision repair defects invoke hypersensitivity to PARP inhibition. Mol Cancer Res. 2014;12:1128-39 pubmed publisher
Janzen D, Paik D, Rosales M, Yep B, Cheng D, Witte O, et al. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Mol Cancer Ther. 2013;12:2917-28 pubmed publisher
Cardnell R, Feng Y, Diao L, Fan Y, Masrorpour F, Wang J, et al. Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. Clin Cancer Res. 2013;19:6322-8 pubmed publisher
Horton J, Wilson S. Predicting enhanced cell killing through PARP inhibition. Mol Cancer Res. 2013;11:13-8 pubmed publisher
Heitz F, du Bois A, Rochon J, Scheil Bertram S, Hils R, Fisseler Eckhoff A, et al. Requirements to assess feasibility of phase 0 trials during major abdominal surgery: variability of PARP activity. Clin Cancer Res. 2012;18:2632-7 pubmed publisher
product information
brand :
R&D Systems
master code :
4520B-096-K
SKU :
4520B-096-K
product name :
HT PARP In Vivo Pharmacodynamic Assay II Kit
unit size :
1 Kit
target :
PARP
category :
DNA Damage and Repair Kits
species :
Multi-Species
USD :
1418 USD
alt names :
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADPRT, ADPRT 1, ADPRTADP-ribosyltransferase NAD(+), EC 2.4.2, EC 2.4.2.30, NAD(+) ADP-ribosyltransferase 1, PARP apoptosis, PARP1, PARP-1, PARPADPRT1, poly (ADP-ribose) polymerase 1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) polymerase, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, PPOL, PPOLpADPRT-1
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.