Recombinant Mouse CXCL2/MIP-2 Protein | R&D Systems 452-M2-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CXCL2/MIP-2 Protein

catalog :

452-M2-010

quantity :

10 ug (also 50 ug)

price :

312 USD

more info or order :

R&D Systems product webpage

citations: 49

Reference
Pajulas A, Fu Y, Cheung C, Chu M, Cannon A, Alakhras N, et al. Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation. Mucosal Immunol. 2023;16:432-445 pubmed publisher
Cheng N, Kim K, Lau L. Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2. JCI Insight. 2022;7: pubmed publisher
Capitano M, Sammour Y, Ropa J, Legendre M, Mor Vaknin N, Markovitz D. DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling. J Leukoc Biol. 2022;112:449-456 pubmed publisher
Adrover J, Aroca Crevillén A, Crainiciuc G, Ostos F, Rojas Vega Y, Rubio Ponce A, et al. Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol. 2020;21:135-144 pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
Hao L, Lei X, Zhou H, Marshall A, Liu L. Critical role for PI3Kγ-dependent neutrophil reactive oxygen species in WKYMVm-induced microvascular hyperpermeability. J Leukoc Biol. 2019;106:1117-1127 pubmed publisher
Capitano M, Mor Vaknin N, Saha A, Cooper S, Legendre M, Guo H, et al. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. J Clin Invest. 2019;129:2555-2570 pubmed publisher
Li W, Feng G, Gauthier J, Lokshina I, Higashikubo R, Evans S, et al. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation. J Clin Invest. 2019;129:2293-2304 pubmed publisher
Su V, Yang K, Chiou S, Chen N, Mo M, Lin C, et al. Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury. Stem Cells. 2019;37:631-639 pubmed publisher
Hossain M, Omran E, Xu N, Liu L. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18: pubmed publisher
Busch C, Hendrikx T, Weismann D, Jäckel S, Walenbergh S, Rendeiro A, et al. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017;65:1181-1195 pubmed publisher
Bueno Silva B, Franchin M, Alves C, Denny C, Colón D, Cunha T, et al. Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine. 2016;23:1583-1590 pubmed publisher
Hossain M, Qadri S, Xu N, Su Y, Cayabyab F, Heit B, et al. Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression. J Immunol. 2015;195:2408-16 pubmed publisher
Spahn J, Li W, Bribriesco A, Liu J, Shen H, Ibricevic A, et al. DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation. J Immunol. 2015;194:4039-48 pubmed publisher
Germena G, Volmering S, Sohlbach C, Zarbock A. Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol. 2015;194:728-38 pubmed publisher
Li S, Pettersson U, Hoorelbeke B, Kolaczkowska E, Schelfhout K, Martens E, et al. Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo. PLoS ONE. 2014;9:e104107 pubmed publisher
Sonego F, Castanheira F, Czaikoski P, Kanashiro A, Souto F, França R, et al. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE. 2014;9:e103734 pubmed publisher
Tancevski I, Nairz M, Duwensee K, Auer K, Schroll A, Heim C, et al. Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2. EMBO Mol Med. 2014;6:810-20 pubmed publisher
Fujihara Y, Takato T, Hoshi K. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells. 2014;32:1208-19 pubmed publisher
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
Zhang Q, Coveney A, Yu S, Liu J, Li Y, Blankson S, et al. Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection. Eur J Immunol. 2013;43:1322-32 pubmed publisher
Spiller F, Carlos D, Souto F, de Freitas A, Soares F, Vieira S, et al. ?1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice. Diabetes. 2012;61:1584-91 pubmed publisher
Sadik C, Kim N, Alekseeva E, Luster A. IL-17RA signaling amplifies antibody-induced arthritis. PLoS ONE. 2011;6:e26342 pubmed publisher
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
Filardy A, Pires D, Nunes M, Takiya C, Freire de Lima C, Ribeiro Gomes F, et al. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J Immunol. 2010;185:2044-50 pubmed publisher
Massena S, Christoffersson G, Hjertström E, Zcharia E, Vlodavsky I, Ausmees N, et al. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood. 2010;116:1924-31 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Wieland C, van der Windt G, Florquin S, McKenzie A, van der Poll T. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 2009;11:524-30 pubmed publisher
Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
Shojaei F, Wu X, ZHONG C, Yu L, Liang X, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450:825-31 pubmed
Santen S, Schramm R, Menger M, Wang Y, Jeppsson B, Thorlacius H. P-selectin glycoprotein ligand-1 regulates chemokine-dependent leukocyte recruitment in colonic ischemia-reperfusion. Inflamm Res. 2007;56:452-8 pubmed
Kile B, Panopoulos A, Stirzaker R, Hacking D, Tahtamouni L, Willson T, et al. Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood. 2007;110:2371-80 pubmed
Liu L, Puri K, Penninger J, Kubes P. Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 2007;110:1191-8 pubmed
Zemann B, Urtz N, Reuschel R, Mechtcheriakova D, Bornancin F, Badegruber R, et al. Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol Lett. 2007;109:56-63 pubmed
Fan X, Patera A, Pong Kennedy A, Deno G, Gonsiorek W, Manfra D, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J Biol Chem. 2007;282:11658-66 pubmed
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, et al. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J Immunol. 2006;177:8650-7 pubmed
Hajjar A, Harvey M, Shaffer S, Goodlett D, Sjostedt A, Edebro H, et al. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun. 2006;74:6730-8 pubmed
Panopoulos A, Zhang L, Snow J, Jones D, Smith A, El Kasmi K, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 2006;108:3682-90 pubmed
Ramos C, Fernandes K, Canetti C, Teixeira M, Silva J, Cunha F. Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur J Immunol. 2006;36:2025-34 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
Rhodes K, Raivich G, Fawcett J. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience. 2006;140:87-100 pubmed
Wislez M, Fujimoto N, Izzo J, Hanna A, Cody D, Langley R, et al. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res. 2006;66:4198-207 pubmed
Mihara K, Smit M, Krajnc Franken M, Gossen J, Rooseboom M, Dokter W. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur J Immunol. 2005;35:2573-82 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Jeyaseelan S, Chu H, Young S, Worthen G. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun. 2004;72:7247-56 pubmed
Cotena A, Gordon S, Platt N. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. J Immunol. 2004;173:6427-32 pubmed
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed
Fulton S, Reba S, Martin T, Boom W. Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect Immun. 2002;70:5322-7 pubmed

product information

master code :

452-M2

SKU :

452-M2-010

product name :

Recombinant Mouse CXCL2/MIP-2 Protein

unit size :

10 ug (also 50 ug)

description :

The Recombinant Mouse CXCL2/MIP-2 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CXCL2/MIP-2 Protein has been validated for the following applications: Bioactivity.

target :

CXCL2/GRO beta/MIP-2/CINC-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

theoretical molecular weight :

8 kDa

gene symbol :

Cxcl2

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 0.500-5.00 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P10889

applications :

Bioactivity

source long :

E. coli -derived mouse CXCL2/GRO beta/MIP-2/CINC-3 protein Ala28-Asn100

source short :

E. coli

USD :

312 USD

alt names :

chemokine (C-X-C motif) ligand 2, CINC-2a, CINC3, CINC-3, C-X-C Motif Chemokine 2, GRO beta, GRO2, GRO2 oncogene, GROb, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, melanoma growth stimulatory activity beta, MGSA beta, MGSA-b, MGSA-beta, MIP2, MIP-2, MIP-2a, MIP2A, MIP2-alpha, SCYB2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage