Recombinant Human Glypican 1 Protein, CF | R&D Systems 4519-GP-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Glypican 1 Protein, CF

catalog :

4519-GP-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Shibata R, Konishi H, Arita T, Yamamoto Y, Matsuda H, Yamamoto T, et al. Extracellular glypican-1 affects tumor progression and prognosis in esophageal cancer. Cancer Med. 2024;13:e70212 pubmed publisher
Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, et al. The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer. Nat Commun. 2023;14:1986 pubmed publisher
Cao Y, Wu J, Zheng X, Lu Y, Piper J, Lu Y, et al. Assessing the activity of antibodies conjugated to upconversion nanoparticles for immunolabeling. Anal Chim Acta. 2022;1209:339863 pubmed publisher
Colin Pierre C, Untereiner V, Sockalingum G, Berthelemy N, Danoux L, Bardey V, et al. Hair Histology and Glycosaminoglycans Distribution Probed by Infrared Spectral Imaging: Focus on Heparan Sulfate Proteoglycan and Glypican-1 during Hair Growth Cycle. Biomolecules. 2021;11: pubmed publisher
Lund M, Howard C, Thurecht K, Campbell D, Mahler S, Walsh B. A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer. 2020;20:1214 pubmed publisher
Asega A, Menezes M, Trevisan Silva D, Cajado Carvalho D, Bertholim L, Oliveira A, et al. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Sci Rep. 2020;10:12912 pubmed publisher
Nishigaki T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hara H, et al. Anti-glypican-1 antibody-drug conjugate is a potential therapy against pancreatic cancer. Br J Cancer. 2020;122:1333-1341 pubmed publisher
Gao W, Xu Y, Liu J, Ho M. Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate. Sci Rep. 2016;6:26245 pubmed publisher

product information

master code :

4519-GP

SKU :

4519-GP-050

product name :

Recombinant Human Glypican 1 Protein, CF

unit size :

50 ug

description :

The Recombinant Human Glypican 1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Glypican 1 Protein, CF has been validated for the following applications: Binding Activity.

target :

Glypican 1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60 kDa, reducing conditions

theoretical molecular weight :

56.8 kDa

gene symbol :

GPC1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhGlypicaná1 at 3á╡g/mL (100 ╡L/well) will bind rhFGF-basic with an apparent KDá á1ánM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P35052

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Glypican 1 protein Asp24-Ser530, with a C-terminal 6-His tag

source short :

NS0

USD :

432 USD

alt names :

FLJ38078, glypican, glypican 1, glypican proteoglycan 1, glypican-1, GPC1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage