Recombinant Mouse ErbB3/Her3 Fc Chimera Protein, CF | R&D Systems 4518-RB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse ErbB3/Her3 Fc Chimera Protein, CF

catalog :

4518-RB-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Schmitt L, Rau A, Seifert O, Honer J, Hutt M, Schmid S, et al. Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. MAbs. 2017;9:831-843 pubmed publisher
Yamauchi J, Miyamoto Y, Chan J, Tanoue A. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008;181:351-65 pubmed publisher

product information

master code :

4518-RB

SKU :

4518-RB-050

product name :

Recombinant Mouse ErbB3/Her3 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse ErbB3/Her3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse ErbB3/Her3 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

ErbB3/Her3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

120-135 kDa, reducing conditions

theoretical molecular weight :

95.6 kDa (monomer)

gene symbol :

Erbb3

details of functionality :

Measured by its ability to bind Recombinant Human NRG1┐▀1/HRG1┐▀1 Extracellular Domain (Catalog # 377-HB ) in a functional ELISA with an estimated KD 15 nM.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q61526

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse ErbB3/Her3 protein Mouse ErbB3 (Ser20 - His641) Accession # Q61526 IEGRMDP Mouse IgG2A (Glu98 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

c-erbB3, EC 2.7.10, EC 2.7.10.1, ErbB-3, erbB3-S, HER3, HER3c-erbB-3, LCCS2, lethal congenital contracture syndrome 2, MDA-BF-1, MGC88033, p180-ErbB3, p45-sErbB3, p85-sErbB3, Proto-oncogene-like protein c-ErbB-3, receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage