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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse CCL3/MIP-1 alpha Protein, CF
catalog :
450-MA-010/CF
quantity :
10 ug (also 50 ug)
price :
340 USD
more info or order :
citations: 31
Reference
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Khoyratty T, Ai Z, Ballesteros I, Eames H, Mathie S, Martín Salamanca S, et al. Distinct transcription factor networks control neutrophil-driven inflammation. Nat Immunol. 2021;: pubmed publisher
Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, et al. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis. Nat Commun. 2020;11:5994 pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
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da Silva J, Moreira Dos Santos T, Sobral L, Queiroz Junior C, Rachid M, Proudfoot A, et al. Relevance of CCL3/CCR5 axis in oral carcinogenesis. Oncotarget. 2017;8:51024-51036 pubmed publisher
Marom A, Barak A, Kramer M, Lewinsky H, Binsky Ehrenreich I, Cohen S, et al. CD84 mediates CLL-microenvironment interactions. Oncogene. 2017;36:628-638 pubmed publisher
Couturier J, Stancu I, Schakman O, Pierrot N, Huaux F, Kienlen Campard P, et al. Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease. J Neuroinflammation. 2016;13:20 pubmed publisher
Poon G, Dong Y, Marshall K, Arif A, Deeg C, Dosanjh M, et al. Hyaluronan Binding Identifies a Functionally Distinct Alveolar Macrophage-like Population in Bone Marrow-Derived Dendritic Cell Cultures. J Immunol. 2015;195:632-42 pubmed publisher
Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, et al. Murine IL-17+ Vγ4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis. BMC Immunol. 2015;16:36 pubmed publisher
Mitchell D, Batich K, Gunn M, Huang M, Sanchez Perez L, Nair S, et al. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature. 2015;519:366-9 pubmed publisher
Sato S, Zhang X. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clin Exp Immunol. 2014;177:102-9 pubmed publisher
Gonzalvo Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, et al. Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol. 2014;192:2366-73 pubmed publisher
Fujihara Y, Takato T, Hoshi K. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells. 2014;32:1208-19 pubmed publisher
Bignon A, Gaudin F, Hemon P, Tharinger H, Mayol K, Walzer T, et al. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol. 2014;192:886-96 pubmed publisher
Reichel C, Puhr Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, et al. C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood. 2012;120:880-90 pubmed publisher
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
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Reichel C, Rehberg M, Bihari P, Moser C, Linder S, Khandoga A, et al. Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling. J Leukoc Biol. 2008;83:864-74 pubmed publisher
Shojaei F, Wu X, ZHONG C, Yu L, Liang X, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450:825-31 pubmed
Penido C, Costa M, Souza M, Costa K, Candea A, Benjamim C, et al. Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway. Int Immunol. 2008;20:129-39 pubmed
Zozulya A, Reinke E, Baiu D, Karman J, Sandor M, Fabry Z. Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. J Immunol. 2007;178:520-9 pubmed
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product information
brand :
R&D Systems
master code :
450-MA/CF
SKU :
450-MA-010/CF
product name :
Recombinant Mouse CCL3/MIP-1 alpha Protein, CF
description :
The Recombinant Mouse CCL3/MIP-1 alpha Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse CCL3/MIP-1 alpha Protein, CF has been validated for the following applications: Bioactivity.
target :
CCL3/MIP-1 alpha
category :
Proteins and Enzymes
unit sizes :
10 ug (also 50 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
7.8 kDa
gene symbol :
CCL3
details of functionality :
Measured by its ability to chemoattract 2-day cultured human monocytes. The ED50 for this effect is 5-25 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 0.4-2.0 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q5QNW0
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse CCL3/MIP-1 alpha Protein, CF
USD :
340 USD
alt names :
C-C motif chemokine 3, MIP1-(a), AI323804, chemokine (C-C motif) ligand 3, G0S19-1, LD78a, LD78alpha, MIP1 alpha, MIP-1 alpha, Mip1a, MIP-1alpha, MIP1-alpha, PAT 464.1, SCYA3, SIS-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.