Recombinant Human Angiopoietin-like 4 Protein, CF | R&D Systems 4487-AN product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Angiopoietin-like 4 Protein, CF

catalog :

4487-AN

quantity :

50 ug

price :

399 USD

citations: 8

Reference
Kang Y, Hsu W, Ou C, Tai H, Hsu H, Yeh K, et al. Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis. Int J Mol Sci. 2020;21: pubmed publisher
Zhang T, Kastrenopoulou A, Larrouture Q, Athanasou N, Knowles H. Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis. BMC Cancer. 2018;18:536 pubmed publisher
Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, et al. Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines. Sci Rep. 2017;7:11127 pubmed publisher
Dotterweich J, Schlegelmilch K, Keller A, Geyer B, Schneider D, Zeck S, et al. Contact of myeloma cells induces a characteristic transcriptome signature in skeletal precursor cells -Implications for myeloma bone disease. Bone. 2016;93:155-166 pubmed publisher
Mathieu M, Iampietro M, Chuchana P, Guérit D, Djouad F, Noel D, et al. Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells. J Biol Chem. 2014;289:8402-12 pubmed publisher
Robal T, Larsson M, Martin M, Olivecrona G, Lookene A. Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. J Biol Chem. 2012;287:29739-52 pubmed publisher
Knowles H, Cleton Jansen A, Korsching E, Athanasou N. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J. 2010;24:4648-59 pubmed publisher
Ma T, Jham B, Hu J, Friedman E, Basile J, Molinolo A, et al. Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A. 2010;107:14363-8 pubmed publisher

product information

brand :

R&D Systems

master code :

4487-AN

SKU :

4487-AN-050

product name :

Recombinant Human Angiopoietin-like 4 Protein, CF

description :

The Recombinant Human Angiopoietin-like 4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Angiopoietin-like 4 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Angiopoietin-like Protein 4/ANGPTL4

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl and CHAPS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

43.6 kDa (monomer)

gene symbol :

ANGPTL4

details of functionality :

Measured by its ability to inhibit lipoprotein lipase activity. Yoshida, K. et al . (2002) J. Lipid Res. 43 :1770. The IC50 value under conditions in which Recombinant Human Lipoprotein Lipase/LPL (Catalog # 9888-LL ) and p-nitrophenyl butyrate are present in 0.1 M sodium phosphate, 0.15 M NaCl, 0.5% Triton® X-100, pH 7.2, is approximately 0.05-2.0 µg/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

4487-AN

accessionNumbers :

Q9BY76

applications :

Inhibition Activity

source :

Mouse myeloma cell line, NS0-derived human Angiopoietin-like Protein 4/ANGPTL4 protein Gly26-Ser406 (Lys163Ala & Arg164Ala), with a C-terminal 6-His tag

2020 USD :

399

2021 USD :

399 USD

alt names :

Angiopoietin like Protein 4, angiopoietin-like 4, Angiopoietin-like protein 4, ANGPTL4, ARP4fasting-induced adipose factor, FIAF, FIAFhepatic angiopoietin-related protein, Hepatic fibrinogen/angiopoietin-related protein, HFARP, HFARPANGPTL2, NL2, peroxisome proliferator-activated receptor (PPAR) gamma inducedangiopoietin-related protein, PGAR, PGARangiopoietin-related protein 4, pp1158, PPARG angiopoietin related protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.