Recombinant Human Angiopoietin-like 4 Protein, CF | R&D Systems 4487-AN-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Angiopoietin-like 4 Protein, CF

catalog :

4487-AN-050

quantity :

50 ug

price :

493 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Shen C, Chan R, Lin B, Li N, Huang Y, Chang W, et al. Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation. Theranostics. 2023;13:4650-4666 pubmed publisher
Hefni E, Menon D, Ma T, Asiedu E, Sultan A, Meiller T, et al. Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway. Cell Signal. 2023;108:110697 pubmed publisher
Cho D, Ahn M, Cho H, Cho M, Jun J, Kang B, et al. ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation. Exp Mol Med. 2023;55:426-442 pubmed publisher
Huang J, Zhang S. Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease. Mediators Inflamm. 2021;2021:9914071 pubmed publisher
Li M, Hu J, Yao L, Gao M. Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure. J Cell Mol Med. 2020;: pubmed publisher
Kang Y, Hsu W, Ou C, Tai H, Hsu H, Yeh K, et al. Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis. Int J Mol Sci. 2020;21: pubmed publisher
Zhang T, Kastrenopoulou A, Larrouture Q, Athanasou N, Knowles H. Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis. BMC Cancer. 2018;18:536 pubmed publisher
Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, et al. Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines. Sci Rep. 2017;7:11127 pubmed publisher
Dotterweich J, Schlegelmilch K, Keller A, Geyer B, Schneider D, Zeck S, et al. Contact of myeloma cells induces a characteristic transcriptome signature in skeletal precursor cells -Implications for myeloma bone disease. Bone. 2016;93:155-166 pubmed publisher
Mathieu M, Iampietro M, Chuchana P, Guérit D, Djouad F, Noel D, et al. Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells. J Biol Chem. 2014;289:8402-12 pubmed publisher
Robal T, Larsson M, Martin M, Olivecrona G, Lookene A. Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. J Biol Chem. 2012;287:29739-52 pubmed publisher
Knowles H, Cleton Jansen A, Korsching E, Athanasou N. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J. 2010;24:4648-59 pubmed publisher
Ma T, Jham B, Hu J, Friedman E, Basile J, Molinolo A, et al. Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc Natl Acad Sci U S A. 2010;107:14363-8 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4487-AN

SKU :

4487-AN-050

product name :

Recombinant Human Angiopoietin-like 4 Protein, CF

Description :

The Recombinant Human Angiopoietin-like 4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Angiopoietin-like 4 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Angiopoietin-like Protein 4/ANGPTL4

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl and CHAPS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

43.6 kDa (monomer)

gene symbol :

ANGPTL4

details of functionality :

Measured by its ability to inhibit lipoprotein lipase activity. Yoshida, K. et al . (2002) J. Lipid Res. 43 :1770. The IC50 value under conditions in which Recombinant Human Lipoprotein Lipase/LPL (Catalog # 9888-LL ) and p-nitrophenyl butyrate are present in 0.1 M sodium phosphate, 0.15 M NaCl, 0.5% Triton® X-100, pH 7.2, is approximately 0.05-2.0 µg/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9BY76

applications :

Inhibition Activity

source :

NS0-derived Recombinant Human Angiopoietin-like 4 Protein

USD :

493 USD

alt names :

Angiopoietin like Protein 4, angiopoietin-like 4, Angiopoietin-like protein 4, ANGPTL4, ARP4fasting-induced adipose factor, FIAF, FIAFhepatic angiopoietin-related protein, Hepatic fibrinogen/angiopoietin-related protein, HFARP, HFARPANGPTL2, NL2, peroxisome proliferator-activated receptor (PPAR) gamma inducedangiopoietin-related protein, PGAR, PGARangiopoietin-related protein 4, pp1158, PPARG angiopoietin related protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage