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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-15 Protein
catalog :
447-ML-010
quantity :
10 ug
price :
355 USD
more info or order :
citations: 59
Reference
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Xiao S, Zhang W, Manley N. Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a. PLoS ONE. 2018;13:e0193188 pubmed publisher
Vicari A, Schoepfer A, Meresse B, Goffin L, Leger O, Josserand S, et al. Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis. MAbs. 2017;9:927-944 pubmed publisher
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Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, et al. A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties. Cell Rep. 2017;19:1431-1443 pubmed publisher
Kavazović I, Lenartic M, Jelencic V, Jurkovic S, Lemmermann N, Jonjic S, et al. NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. Eur J Immunol. 2017;47:1123-1135 pubmed publisher
Antonangeli F, Soriani A, Ricci B, Ponzetta A, Benigni G, Morrone S, et al. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells. Oncoimmunology. 2016;5:e1218105 pubmed
Li K, Fähnrich A, Roy E, Cuda C, Grimes H, PERLMAN H, et al. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire. J Immunol. 2017;198:257-269 pubmed
Jones R, Mueller S, O Connor R, Rimpel K, Sloan D, Karel D, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12:e1005545 pubmed publisher
Holmkvist P, Pool L, Hägerbrand K, Agace W, Rivollier A. IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness. Eur J Immunol. 2016;46:1371-82 pubmed publisher
Fiege J, Burbach B, Shimizu Y. Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein. J Immunol. 2015;195:3119-28 pubmed publisher
Harris T, McGargill M. Drak2 Does Not Regulate TGF-β Signaling in T Cells. PLoS ONE. 2015;10:e0123650 pubmed publisher
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Pennati A, Deng J, Galipeau J. Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives. PLoS ONE. 2014;9:e106724 pubmed publisher
Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, et al. Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ. 2015;22:174-84 pubmed publisher
Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, et al. The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. PLoS ONE. 2014;9:e103254 pubmed publisher
Marcais A, Cherfils Vicini J, Viant C, Degouve S, Viel S, Fenis A, et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol. 2014;15:749-757 pubmed publisher
Celis Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, et al. Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014;33:1928-40 pubmed publisher
Freeman B, Meyer C, Slifka M. Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions. J Virol. 2014;88:7474-84 pubmed publisher
Krupnick A, Lin X, Li W, Higashikubo R, Zinselmeyer B, Hartzler H, et al. Central memory CD8+ T lymphocytes mediate lung allograft acceptance. J Clin Invest. 2014;124:1130-43 pubmed publisher
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Quinn L, Anderson B, Conner J, Wolden Hanson T, Marcell T. IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice. Endocrinology. 2014;155:143-55 pubmed publisher
Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, et al. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity. 2013;38:742-53 pubmed publisher
Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U. The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol. 2013;190:5128-41 pubmed publisher
Ahmed Rahim M, Chrobak P, Priceputu E, Hanna Z, Jolicoeur P. Normal development and function but impaired memory phenotype of CD8? T cells in transgenic mice expressing HIV-1 Nef in its natural target cells. Virology. 2013;438:84-97 pubmed publisher
Golden Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, et al. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013;87:4835-45 pubmed publisher
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Kurtulus S, Tripathi P, Moreno Fernandez M, Sholl A, Katz J, Grimes H, et al. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J Immunol. 2011;186:5729-37 pubmed publisher
Depaolo R, Abadie V, Tang F, Fehlner Peach H, Hall J, Wang W, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011;471:220-4 pubmed publisher
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Zaph C, Du Y, Saenz S, Nair M, Perrigoue J, Taylor B, et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med. 2008;205:2191-8 pubmed publisher
Pan W, Hsuchou H, Yu C, Kastin A. Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. J Neurochem. 2008;106:313-9 pubmed publisher
Wan N, Dai H, Wang T, Moore Y, Zheng X, Dai Z. Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection. J Immunol. 2008;180:113-21 pubmed
Zheng S, Wang J, Wang P, Gray J, Horwitz D. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007;178:2018-27 pubmed
Rafei M, Wu J, Annabi B, Lejeune L, Francois M, Galipeau J. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood. 2007;109:2234-42 pubmed
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product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
447-ML
SKU :
447-ML-010
product name :
Recombinant Mouse IL-15 Protein
description :
The Recombinant Mouse IL-15 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-15 Protein has been validated for the following applications: Bioactivity.
target :
IL-15
unit size :
10 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris and NaCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
13.4 kDa
gene symbol :
Il15
details of functionality :
Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 2-15 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P48346
applications :
Bioactivity
product keywords :
447-ML, rmIL-15, mIL-15,, 447ML, cytokinegrowthfact, IL15, IL 15, Interleukin-15, Interleukin 15, cytokine, cytokines,
source :
E. coli-derived Recombinant Mouse IL-15 Protein
USD :
351
USD 2025 :
355 USD
alt names :
IL15, IL-15MGC9721, interleukin 15, interleukin-15
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.