Recombinant Human CD39/ENTPD1 Protein, CF | R&D Systems 4397-EN-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CD39/ENTPD1 Protein, CF

catalog :

4397-EN-010

quantity :

10 ug

price :

443 USD

citations: 7

Reference
Hong C, Menshikova E, Whiteside T, Jackson E. Assessment of ATP Metabolism to Adenosine by Ecto-Nucleotidases Carried by Tumor-Derived Small Extracellular Vesicles. Res Sq. 2024;: pubmed publisher
Vadlamani V, Gunasinghe K, Chee X, Rahman T, Harper M. Human soluble CD39 displays substrate inhibition in a substrate-specific manner. Sci Rep. 2023;13:8958 pubmed publisher
Muñóz Godínez R, de Lourdes Mora García M, Weiss Steider B, Montesinos Montesinos J, Del Carmen Aguilar Lemarroy A, García Rocha R, et al. Detection of CD39 and a Highly Glycosylated Isoform of Soluble CD73 in the Plasma of Patients with Cervical Cancer: Correlation with Disease Progression. Mediators Inflamm. 2020;2020:1678780 pubmed publisher
de Lourdes Mora García M, López Cisneros S, Gutiérrez Serrano V, García Rocha R, Weiss Steider B, Hernández Montes J, et al. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators Inflamm. 2019;2019:4651627 pubmed publisher
Perrot I, Michaud H, Giraudon Paoli M, Augier S, Docquier A, Gros L, et al. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep. 2019;27:2411-2425.e9 pubmed publisher
Degen H, Borst O, Ziegler M, Mojica Munoz A, Jamasbi J, Walker B, et al. ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions. J Am Heart Assoc. 2017;6: pubmed publisher
Townley Tilson W, Wu Y, Ferguson J, Patterson C. The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. PLoS ONE. 2014;9:e89451 pubmed publisher

product information

master code :

4397-EN

SKU :

4397-EN-010

product name :

Recombinant Human CD39/ENTPD1 Protein, CF

unit size :

10 ug

description :

The Recombinant Human CD39/ENTPD1 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human CD39/ENTPD1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

CD39/ENTPD1

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris, NaCl, CaCl2 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining

species :

Human

observed molecular weight :

65-90 kDa, reducing conditions

theoretical molecular weight :

51 kDa

gene symbol :

ENTPD1

details of functionality :

Measured by its ability to hydrolyze the 5Æ-phosphate groups from the substrate adenosine-5Æ-triphosphate (ATP). The orthophosphate product is measured by a Malachite Green Phosphate Detection Kit (Catalog # DY996 ). The specific activity is 5,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P49961

applications :

Enzyme Activity

source long :

Chinese Hamster Ovary cell line, CHO-derived human CD39/ENTPD1 protein Thr38-Val478, with a C-terminal 6-His tag

source short :

CHO

USD :

443 USD

alt names :

ADPase, ATPDase, ATP-diphosphatase, CD39, CD39 antigen, CD39EC 3.6.1.5, DKFZp686D194, DKFZp686I093, EC 3.6.1, Ecto-apyrase, Ecto-ATP diphosphohydrolase 1, Ecto-ATPase 1, Ecto-ATPDase 1, ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, FLJ40921, FLJ40959, Lymphoid cell activation antigen, NTPD1, NTPDase 1, NTPDase-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.