Recombinant Mouse Fas/TNFRSF6/CD95 Fc Chimera Protein | R&D Systems 435-FA-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Fas/TNFRSF6/CD95 Fc Chimera Protein

catalog :

435-FA-050

quantity :

50 ug

price :

432 USD

citations: 5

Reference
Kamiya M, Mizoguchi F, Kawahata K, Wang D, Nishibori M, Day J, et al. Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies. Nat Commun. 2022;13:166 pubmed publisher
Choi I, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, et al. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018;115:E686-E695 pubmed publisher
Deegan S, Saveljeva S, Logue S, Pakos Zebrucka K, Gupta S, Vandenabeele P, et al. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10:1921-36 pubmed publisher
Wetzel M, Li L, Harms K, Roitbak T, Ventura P, Rosenberg G, et al. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death Differ. 2008;15:143-51 pubmed
Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol. 2006;177:5041-50 pubmed

product information

master code :

435-FA

SKU :

435-FA-050

product name :

Recombinant Mouse Fas/TNFRSF6/CD95 Fc Chimera Protein

unit size :

50 ug

description :

The Recombinant Mouse Fas/TNFRSF6/CD95 Fc Chimera Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse Fas/TNFRSF6/CD95 Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

Fas/TNFRSF6/CD95

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

55 kDa, reducing conditions

theoretical molecular weight :

46 kDa (monomer)

gene symbol :

Fas

details of functionality :

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.03-0.1 ╡g/mL in the presence of 20 ng/mL recombinant human Fas-ligand.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P25446

applications :

Bioactivity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived mouse Fas/TNFRSF6/CD95 protein Mouse FAS (Gly14 - Arg169) Accession # P25446 DIEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

source short :

Sf 21 (baculovirus)

USD :

432 USD

alt names :

Apo-1, Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1, APT1FASTM, CD95, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.