Recombinant Mouse CTLA-4 Fc Chimera Protein | R&D Systems 434-CT-200 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CTLA-4 Fc Chimera Protein

catalog :

434-CT-200

quantity :

200 ug (also 1 mg)

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Morimoto J, Matsumoto M, Miyazawa R, Yoshida H, Tsuneyama K, Matsumoto M. Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity. Cell Rep. 2022;38:110384 pubmed publisher
Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, et al. ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models. PLoS ONE. 2020;15:e0239595 pubmed publisher
Sandin L, Eriksson F, Ellmark P, Loskog A, Totterman T, Mangsbo S. Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo. Oncoimmunology. 2014;3:e27614 pubmed
Stojanovic A, Fiegler N, Brunner Weinzierl M, Cerwenka A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J Immunol. 2014;192:4184-91 pubmed publisher
Peng Y, Luo G, Zhou J, Wang X, Hu J, Cui Y, et al. CD86 is an activation receptor for NK cell cytotoxicity against tumor cells. PLoS ONE. 2013;8:e83913 pubmed publisher
Kowalczyk A, D Souza C, Zhang L. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol. 2014;44:1143-55 pubmed publisher
Leitner J, Rieger A, Pickl W, Zlabinger G, Grabmeier Pfistershammer K, Steinberger P. TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 2013;9:e1003253 pubmed publisher
Khan A, Fu H, Tan L, Harper J, Beutelspacher S, Larkin D, et al. Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition. Eur J Immunol. 2013;43:734-46 pubmed publisher
Butte M, Keir M, Phamduy T, Sharpe A, Freeman G. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111-22 pubmed
Anderson K, Czinn S, Redline R, Blanchard T. Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection. J Immunol. 2006;176:5306-13 pubmed
La Cava A, Ebling F, Hahn B. Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J Immunol. 2004;173:3542-8 pubmed
Bonham C, Peng L, Liang X, Chen Z, Wang L, Ma L, et al. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol. 2002;169:3382-91 pubmed

image

image 1 :

Recombinant Mouse CTLA-4 Fc Chimera Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

434-CT

SKU :

434-CT-200

product name :

Recombinant Mouse CTLA-4 Fc Chimera Protein

Description :

The Recombinant Mouse CTLA-4 Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Mouse CTLA-4 Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

CTLA-4

category :

Proteins and Enzymes

unit size :

200 ug (also 1 mg)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

55 kDa, reducing conditions

theoretical molecular weight :

41 kDa (monomer)

gene symbol :

Ctla4

details of functionality :

Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Linsley, P.S. et al . (1991) J. Exp. Med. 174 :561. The ED50 for this effect is 0.1-0.4 µg/mL when stimulated with 1 µg/mL Recombinant Human B7-1/CD80 Fc Chimera (Catalog # 140-B1 ) in the presence of PHA.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6GTR6

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse CTLA-4 Fc Chimera Protein

USD :

470 USD

alt names :

CD, CD152, CD152 antigen, CD152IDDM12, CD28, celiac disease 3, CELIAC3, CTLA4, CTLA-4, cytotoxic T-lymphocyte antigen 4, cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte-associated serine esterase-4, GRD4, GSE, ICOS, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage