Recombinant Human Fc gamma RIIIA/CD16a Protein, CF | R&D Systems 4325-FC-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fc gamma RIIIA/CD16a Protein, CF

catalog :

4325-FC-050

quantity :

50 ug

price :

443 USD

citations: 22

Reference
Pascual Pasto G, McIntyre B, Hines M, Giudice A, Garcia Gerique L, Hoffmann J, et al. CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma. Nat Commun. 2024;15:7141 pubmed publisher
Sun H, Yang M, Lai H, Neupane B, Teh A, Jugler C, et al. A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody Therapeutics. Viruses. 2023;15: pubmed publisher
Torchia J, Tavares A, Carstensen L, Chen D, Huang J, Xiao T, et al. Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Sci Adv. 2022;8:eabq6527 pubmed publisher
Bates T, Lu P, Kang Y, Schoen D, Thornton M, McBride S, et al. BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age. Cell Rep. 2022;41:111544 pubmed publisher
Noy Porat T, Edri A, Alcalay R, Makdasi E, Gur D, Aftalion M, et al. Fc-Independent Protection from SARS-CoV-2 Infection by Recombinant Human Monoclonal Antibodies. Antibodies (Basel). 2021;10: pubmed publisher
Kitanaga Y, Yamajuku D, Kubo S, Nakamura K, Maeda M, Seki M, et al. Discovery of a novel Igβ and FcγRIIB cross-linking antibody, ASP2713, and its potential application in the treatment of systemic lupus erythematosus. Int Immunopharmacol. 2021;101:108343 pubmed publisher
Vanhove B, Duvaux O, Rousse J, Royer P, Evanno G, Ciron C, et al. High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2. Eur J Immunol. 2021;51:1412-1422 pubmed publisher
Domján J, Vass P, Hirsch E, Szabó E, Pantea E, Andersen S, et al. Monoclonal antibody formulation manufactured by high-speed electrospinning. Int J Pharm. 2020;591:120042 pubmed publisher
Blundell P, Lu D, Wilkinson M, Dell A, Haslam S, Pleass R. Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus. J Immunol. 2019;202:1595-1611 pubmed publisher
Wozniak Knopp G, Stadlmayr G, Perthold J, Stadlbauer K, Gotsmy M, Becker S, et al. An antibody with Fab-constant domains exchanged for a pair of CH3 domains. PLoS ONE. 2018;13:e0195442 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Lee C, Jeong M, Lee J, Seo S, Cho S, Zhang W, et al. Glycosylation profile and biological activity of Remicade® compared with Flixabi® and Remsima®. MAbs. 2017;9:968-977 pubmed publisher
Le Clorennec C, BAZIN H, Dubreuil O, Larbouret C, Ogier C, Lazrek Y, et al. Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3. Mol Cancer Ther. 2017;16:1312-1323 pubmed publisher
Lohse S, Meyer S, Meulenbroek L, Jansen J, Nederend M, Kretschmer A, et al. An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo. Cancer Res. 2016;76:403-17 pubmed publisher
Yang Z, Ramsey J, Hamza T, Zhang Y, Li S, Yfantis H, et al. Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun. 2015;83:822-31 pubmed publisher
Anikeeva N, Steblyanko M, Fayngerts S, Kopylova N, Marshall D, Powers G, et al. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity. Eur J Immunol. 2014;44:2331-9 pubmed publisher
Xie J, Yamniuk A, Borowski V, Kuhn R, Susulic V, Rex Rabe S, et al. Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases. J Immunol. 2014;192:4083-92 pubmed publisher
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed publisher
Franco A, Damdinsuren B, Ise T, Dement Brown J, Li H, Nagata S, et al. Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors. J Immunol. 2013;190:5739-46 pubmed publisher
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Wei Y, Li C, Huang W, Li B, Strome S, Wang L. Glycoengineering of human IgG1-Fc through combined yeast expression and in vitro chemoenzymatic glycosylation. Biochemistry. 2008;47:10294-304 pubmed publisher

product information

master code :

4325-FC

SKU :

4325-FC-050

product name :

Recombinant Human Fc gamma RIIIA/CD16a Protein, CF

unit size :

50 ug

description :

The Recombinant Human Fc gamma RIIIA/CD16a Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fc gamma RIIIA/CD16a Protein, CF has been validated for the following applications: Binding Activity.

target :

Fc gamma RIIIA/CD16a

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

40-50 kDa, reducing conditions

theoretical molecular weight :

22.6 kDa

gene symbol :

FCGR3A

details of functionality :

Measured by its ability to bind human IgG with an estimated Kd 50 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAH17865

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Fc gamma RIIIA/CD16a protein Gly17-Gln208, with a C-terminal 6-His tag

source short :

NS0

extended description :

Analyzed by SEC-MALS, Isoform V176, His-tag

USD :

443 USD

product details :

Analyzed by SEC-MALS, Isoform V176, His-tag

alt names :

CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGR3A, FCGRIII, FcgRIIIA, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.