Recombinant Human ADAMTS4 Protein, CF | R&D Systems 4307-AD-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS4 Protein, CF

catalog :

4307-AD-020

quantity :

20 ug

price :

417 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Kaufmann J, Brangsch J, Kader A, Saatz J, Mangarova D, Zacharias M, et al. ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries. Nat Commun. 2022;13:2867 pubmed publisher
Fontanil T, Mohamedi Y, Moncada Pazos A, Cobo T, Vega J, Cobo J, et al. Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. Cell Physiol Biochem. 2019;52:1003-1016 pubmed publisher
Fontanil T, Álvarez Teijeiro S, Villaronga M, Mohamedi Y, Solares L, Moncada Pazos A, et al. Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells. Oncotarget. 2017;8:13716-13729 pubmed publisher
Lemarchant S, Pomeshchik Y, Kidin I, KÃ¤rkkÃ¤inen V, Valonen P, Lehtonen S, et al. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener. 2016;11:10 pubmed publisher
Rao N, Ke Z, Liu H, Ho C, Kumar S, Xiang W, et al. ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. Int J Cancer. 2013;133:294-306 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Tauchi R, Imagama S, Natori T, Ohgomori T, Muramoto A, Shinjo R, et al. The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. J Neuroinflammation. 2012;9:53 pubmed publisher
Weaver M, Workman G, Cardo Vila M, Arap W, Pasqualini R, Sage E. Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. J Biol Chem. 2010;285:5868-77 pubmed publisher

product information

brand :

R&D Systems

master code :

4307-AD

SKU :

4307-AD-020

product name :

Recombinant Human ADAMTS4 Protein, CF

description :

The Recombinant Human ADAMTS4 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human ADAMTS4 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS4

category :

Proteins and Enzymes

sizes available :

20 ug

buffer :

Supplied as a 0.2 µm filtered solution in Sodium Acetate, CaCl2 and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

58 kDa, reducing conditions

theoretical molecular weight :

53 kDa

gene symbol :

ADAMTS4

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Abz-TEGEARGSVI-Dap(Dnp)-KK-NH2. The specific activity is 7 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O75173

applications :

Enzyme Activity

source :

CHO-derived Recombinant Human ADAMTS4 Protein, CF

USD :

410

USD 2023 :

417 USD

alt names :

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4, ADAM metallopeptidase with thrombospondin type 1 motif, 4, ADAM-TS 4, ADAMTS-2, ADAM-TS4, ADAMTS-4, ADMP-1, ADMP-1EC 3.4.24.82, Aggrecanase 1, aggrecanase-1, EC 3.4.24, KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage