Recombinant Human MSP/MST1 (Cys672Ala) Protein | R&D Systems 4306-MS-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MSP/MST1 (Cys672Ala) Protein

catalog :

4306-MS-010

quantity :

10 ug

price :

365 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Hunt B, Jones A, Lester C, Davis J, Benight N, Waltz S. RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk. Cancers (Basel). 2022;14: pubmed publisher
Dey A, Allen J, Fraser J, Snyder L, Tian Y, Zhang L, et al. Neuroprotective Role of the Ron Receptor Tyrosine Kinase Underlying Central Nervous System Inflammation in Health and Disease. Front Immunol. 2018;9:513 pubmed publisher
Privette Vinnedge L, Benight N, Wagh P, Pease N, Nashu M, Serrano López J, et al. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene. 2015;34:2325-36 pubmed publisher
Wang X, Yennawar N, Hankey P. Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain. Cell Commun Signal. 2014;12:28 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4306-MS

SKU :

4306-MS-010

product name :

Recombinant Human MSP/MST1 (Cys672Ala) Protein

Description :

The Recombinant Human MSP/MST1 (Cys672Ala) Protein from R&D Systems is derived from CHO. The Recombinant Human MSP/MST1 (Cys672Ala) Protein has been validated for the following applications: Bioactivity.

target :

MSP/MST1

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

60 kDa and 30 kDa, reducing conditions

theoretical molecular weight :

53 kDa ( alpha-chain), 25 kDa ( beta-chain)

gene symbol :

MST1

details of functionality :

Measured by its ability to activate MSP R/Ron in MDA-MB-453 or T47D human breast cancer cells. 80 ng/mL of the recombinant human MSP (C672A) significantly induces phosphorylation of MSP R/Ron measured by the Human Phospho-MSP R/Ron DuoSet® IC Kit (Catalog # DYC1947 ). Measured by its binding ability in a functional ELISA. When Recombinant Human MSPR/Ron Protein (Catalog #1947-MS) is represent at 100 ng/mL (100 µg/mL), The concentration of Recombinant Human MSP/MST1 that produces 50% optimal binding response is found to be 4-32 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAA59872

applications :

Bioactivity

source :

CHO-derived Recombinant Human MSP/MST1 (Cys672Ala) Protein

USD :

365 USD

alt names :

D3F15S2, EC 3.4.21, hepatocyte growth factor-like protein homolog, HGFL, HGFLhepatocyte growth factor-like protein, macrophage stimulating 1 (hepatocyte growth factor-like), Macrophage stimulatory protein, Macrophage-stimulating protein, MSPDNF15S2, MST1, NF15S2, SF2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage