Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF | R&D Systems 430-RI-050/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF

catalog :

430-RI-050/CF

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Goodall L, Ovecka M, Rycroft D, Friel S, Sanderson A, Mistry P, et al. Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension. PLoS ONE. 2015;10:e0137065 pubmed publisher
Pontejo S, Alejo A, Alcami A. Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors. J Biol Chem. 2015;290:15973-84 pubmed publisher
Bruggeman L, Drawz P, Kahoud N, Lin K, Barisoni L, Nelson P. TNFR2 interposes the proliferative and NF-?B-mediated inflammatory response by podocytes to TNF-?. Lab Invest. 2011;91:413-25 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

430-RI/CF

SKU :

430-RI-050/CF

product name :

Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF

Description :

The Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TNF RI/TNFRSF1A

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

70 kDa, reducing conditions

theoretical molecular weight :

48.6 kDa (monomer)

gene symbol :

Tnfrsf1a

details of functionality :

Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 0.75-4.5 ng/mL in the presence of 0.1 ng/mL recombinant mouse TNF-alpha .

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P25118

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse TNF RI/TNFRSF1A Fc Chimera Protein

USD :

423 USD

alt names :

CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage