Recombinant Mouse Nephronectin Protein, CF | R&D Systems 4298-NP-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Nephronectin Protein, CF

catalog :

4298-NP-050

quantity :

50 ug

price :

499 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Basta J, Robbins L, Stout L, Prinsen M, Griggs D, Rauchman M. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiol Rep. 2020;8:e14329 pubmed publisher
Kon S, Honda M, Ishikawa K, Maeda M, Segawa T. Antibodies against nephronectin ameliorate anti-type II collagen-induced arthritis in mice. FEBS Open Bio. 2020;10:107-117 pubmed publisher
Hung C, Wilson C, Chow Y, Schnapp L. Role of integrin alpha8 in murine model of lung fibrosis. PLoS ONE. 2018;13:e0197937 pubmed publisher
Steigedal T, Toraskar J, Redvers R, Valla M, Magnussen S, Bofin A, et al. Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. Neoplasia. 2018;20:387-400 pubmed publisher
Tang J, Saito T. The Role of Nephronectin on Proliferation and Differentiation in Human Dental Pulp Stem Cells. Stem Cells Int. 2017;2017:2546261 pubmed publisher
Teo A, Garg S, Johnson T, Zhao W, Zhou J, GOMEZ SANCHEZ C, et al. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017;69:1207-1216 pubmed publisher
Arai C, Yoshizaki K, Miyazaki K, Saito K, Yamada A, Han X, et al. Nephronectin plays critical roles in Sox2 expression and proliferation in dental epithelial stem cells via EGF-like repeat domains. Sci Rep. 2017;7:45181 pubmed publisher
Zhang H, Tasnim F, Ying J, Zink D. The impact of extracellular matrix coatings on the performance of human renal cells applied in bioartificial kidneys. Biomaterials. 2009;30:2899-911 pubmed publisher

image

image 1 :

Recombinant Mouse Nephronectin Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4298-NP

SKU :

4298-NP-050

product name :

Recombinant Mouse Nephronectin Protein, CF

Description :

The Recombinant Mouse Nephronectin Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Nephronectin Protein, CF has been validated for the following applications: Bioactivity.

target :

Nephronectin

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

80-95 kDa, reducing conditions

theoretical molecular weight :

60.3 kDa

gene symbol :

Npnt

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of SVEC4-10 mouse vascular endothelial cells. When 5 x 104 cells/well are added to rmNephronectin coated plates (10 µg/mL, 100 µL/well), approximately 50-80% will adhere after 1 hour at 37 °C.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAH68308

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Nephronectin Protein

USD :

499 USD

alt names :

EGFL6L, Nctn, nephronectin, NPNT, POEM

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage