Recombinant Mouse CCL12/MCP-5 Protein | R&D Systems 428-P5-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CCL12/MCP-5 Protein

catalog :

428-P5-025

quantity :

25 ug

price :

300 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Barakat R, Chatterjee J, Mu R, Qi X, Gu X, Smirnov I, et al. Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth. Nat Commun. 2024;15:10312 pubmed publisher
Broquet A, Gourain V, Goronflot T, Le Mabecque V, Sinha D, Ashayeripanah M, et al. Sepsis-trained macrophages promote antitumoral tissue-resident T cells. Nat Immunol. 2024;25:802-819 pubmed publisher
Ma C, Gao J, Liang J, Wang F, Xu L, Bu J, et al. CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury. Exp Mol Med. 2023;55:818-830 pubmed publisher
Popiolek Barczyk K, Ciechanowska A, Ciapała K, Pawlik K, Oggioni M, Mercurio D, et al. The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury, and CCL2 modulates the complement system in microglia. Mol Cell Probes. 2020;54:101671 pubmed publisher
Kwiatkowski K, Popiolek Barczyk K, Piotrowska A, Rojewska E, Ciapała K, Makuch W, et al. Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia. Cytokine. 2019;119:202-213 pubmed publisher
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed

product information

master code :

428-P5

SKU :

428-P5-025

product name :

Recombinant Mouse CCL12/MCP-5 Protein

unit size :

25 ug

description :

The Recombinant Mouse CCL12/MCP-5 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CCL12/MCP-5 Protein has been validated for the following applications: Bioactivity.

target :

CCL12/MCP-5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

9.3 kDa

gene symbol :

Ccl12

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A. The ED50 for this effect is 5-30 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q62401.1

applications :

Bioactivity

source long :

E. coli -derived mouse CCL12/MCP-5 protein Gly23-Gly104

source short :

E. coli

USD :

300 USD

alt names :

C-C motif chemokine 12, chemokine (C-C motif) ligand 12, MCP5, MCP-5, Scya12

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage