Recombinant Mouse sTNF RI/TNFRSF1A Protein | R&D Systems 425-R1-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse sTNF RI/TNFRSF1A Protein

catalog :

425-R1-050

quantity :

50 ug

price :

456 USD

citations: 16

Reference
Kleidonas D, Vlachos A. Scavenging Tumor Necrosis Factor α Does Not Affect Inhibition of Dentate Granule Cells Following In Vitro Entorhinal Cortex Lesion. Cells. 2021;10: pubmed publisher
Dykstra Aiello C, Koh K, Nguyen J, Xue M, Roy S, Krueger J. A wake-like state in vitro induced by transmembrane TNF/soluble TNF receptor reverse signaling. Brain Behav Immun. 2021;94:245-258 pubmed publisher
Muldoon J, Chuang Y, Bagheri N, Leonard J. Macrophages employ quorum licensing to regulate collective activation. Nat Commun. 2020;11:878 pubmed publisher
Song D, Meng J, Cheng J, Fan Z, Chen P, Ruan H, et al. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. Nat Microbiol. 2019;4:97-111 pubmed publisher
Goodall L, Ovecka M, Rycroft D, Friel S, Sanderson A, Mistry P, et al. Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension. PLoS ONE. 2015;10:e0137065 pubmed publisher
Steeland S, PuimÃ¨ge L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, et al. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J Biol Chem. 2015;290:4022-37 pubmed publisher
Freeman B, Meyer C, Slifka M. Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions. J Virol. 2014;88:7474-84 pubmed publisher
Huie J, Baumbauer K, Lee K, Bresnahan J, Beattie M, Ferguson A, et al. Glial tumor necrosis factor alpha (TNF?) generates metaplastic inhibition of spinal learning. PLoS ONE. 2012;7:e39751 pubmed publisher
Mitchell H, White D, Domowicz M, Kraig R. Cold pre-conditioning neuroprotection depends on TNF-? and is enhanced by blockade of interleukin-11. J Neurochem. 2011;117:187-96 pubmed publisher
Kaneko M, Stellwagen D, Malenka R, Stryker M. Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron. 2008;58:673-80 pubmed publisher
Domercq M, Brambilla L, Pilati E, Marchaland J, Volterra A, Bezzi P. P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins. J Biol Chem. 2006;281:30684-96 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Ellaban E, Bolgos G, Remick D. Selective macrophage suppression during sepsis. Cell Immunol. 2004;231:103-11 pubmed
Lambertsen K, Gregersen R, Meldgaard M, Clausen B, Heibøl E, Ladeby R, et al. A role for interferon-gamma in focal cerebral ischemia in mice. J Neuropathol Exp Neurol. 2004;63:942-55 pubmed
LaBue M, Colburn K, Green L. Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity. Thyroid. 2004;14:249-62 pubmed

product information

master code :

425-R1

SKU :

425-R1-050

product name :

Recombinant Mouse sTNF RI/TNFRSF1A Protein

unit size :

50 ug

description :

The Recombinant Mouse sTNF RI/TNFRSF1A Protein from R&D Systems is derived from E. coli. The Recombinant Mouse sTNF RI/TNFRSF1A Protein has been validated for the following applications: Bioactivity.

target :

TNF RI/TNFRSF1A

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

theoretical molecular weight :

21 kDa

gene symbol :

Tnfrsf1a

details of functionality :

Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews,áN. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 0.1-0.6 ╡g/mL in the presence of 0.1 ng/mL of recombinant mouse TNF-alpha .

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P25118

applications :

Bioactivity

source long :

E. coli -derived mouse TNF RI/TNFRSF1A protein Ile22-Ala212, with an N-terminal Met

source short :

E. coli

USD :

456 USD

alt names :

CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.