Recombinant Human ADAMTS13 Protein, CF | R&D Systems 4245-AD-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAMTS13 Protein, CF

catalog :

4245-AD-020

quantity :

20 ug

price :

476 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Xu H, Cao Y, Yang X, Cai P, Kang L, Zhu X, et al. ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery. Blood. 2017;130:11-22 pubmed publisher
Desch K, Kretz C, Yee A, Gildersleeve R, Metzger K, Agrawal N, et al. Probing ADAMTS13 substrate specificity using phage display. PLoS ONE. 2015;10:e0122931 pubmed publisher
Tersteeg C, de Maat S, De Meyer S, Smeets M, Barendrecht A, Roest M, et al. Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy. Circulation. 2014;129:1320-31 pubmed publisher
Tauchi R, Imagama S, Natori T, Ohgomori T, Muramoto A, Shinjo R, et al. The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. J Neuroinflammation. 2012;9:53 pubmed publisher
Zhou M, Dong X, Baldauf C, Chen H, Zhou Y, Springer T, et al. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood. 2011;117:4623-31 pubmed publisher

product information

brand :

R&D Systems

master code :

4245-AD

SKU :

4245-AD-020

product name :

Recombinant Human ADAMTS13 Protein, CF

description :

The Recombinant Human ADAMTS13 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human ADAMTS13 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAMTS13

category :

Proteins and Enzymes

sizes available :

20 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

90 kDa, reducing conditions

theoretical molecular weight :

68 kDa

gene symbol :

ADAMTS13

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, FRETS-VWF73. The specific activity is 10 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_620594

applications :

Enzyme Activity

source :

CHO-derived Recombinant Human ADAMTS13 Protein, CF

USD :

453

USD 2023 :

476 USD

alt names :

A disintegrin and metalloproteinase with thrombospondin motifs 13, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 13, ADAM metallopeptidase with thrombospondin type 1 motif, 13, ADAM-TS13, ADAMTS-13, DKFZp434C2322, EC 3.4.24.14, EC 3.4.24.82, EC 3.4.24.87, FLJ42993, MGC118899, MGC118900, TTP, TTPADAM-TS 13, vWF-cleaving protease, vWF-CP, vWF-CPC9orf8, VWFCPvon Willebrand factor-cleaving protease

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage