product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human PSMA/FOLH1 Protein, CF
catalog :
4234-ZN-010
quantity :
10 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 8
Reference
Skidmore L, Mills D, Kim J, Knudsen N, Nelson J, Pal M, et al. Preclinical Characterization of ARX517, a Site-Specific Stable PSMA-Targeted Antibody-Drug Conjugate for the Treatment of Metastatic Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2024;23:1842-1853 pubmed publisher
Xu B, Yan M, Zhou F, Cai D, Guo W, Jia X, et al. Prostate-Specific Membrane Antigen and Esterase Dual Responsive Camptothecin-Oligopeptide Self-Assembled Nanoparticles for Efficient Anticancer Drug Delivery. Int J Nanomedicine. 2021;16:7959-7974 pubmed publisher
Löffler J, Hamp C, Scheidhauer E, Di Carlo D, Solbach C, Abaei A, et al. Comparison of Quantification of Target-Specific Accumulation of [18F]F-siPSMA-14 in the HET-CAM Model and in Mice Using PET/MRI. Cancers (Basel). 2021;13: pubmed publisher
Winter G, Vogt A, Jiménez Franco L, Rinscheid A, Yousefzadeh Nowshahr E, Solbach C, et al. Modelling the internalisation process of prostate cancer cells for PSMA-specific ligands. Nucl Med Biol. 2019;72-73:20-25 pubmed publisher
Xu X, Dickey D, Chen S, Giangrande P. Structural computational modeling of RNA aptamers. Methods. 2016;103:175-9 pubmed publisher
Dassie J, Hernandez L, Thomas G, Long M, Rockey W, Howell C, et al. Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen. Mol Ther. 2014;22:1910-22 pubmed publisher
Hernandez L, Flenker K, Hernandez F, Klingelhutz A, McNamara J, Giangrande P. Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers. Pharmaceuticals (Basel). 2013;6:295-319 pubmed
Meany D, Hackler L, Zhang H, Chan D. Tyramide signal amplification for antibody-overlay lectin microarray: a strategy to improve the sensitivity of targeted glycan profiling. J Proteome Res. 2011;10:1425-31 pubmed publisher
product information
master code :
4234-ZN
SKU :
4234-ZN-010
product name :
Recombinant Human PSMA/FOLH1 Protein, CF
unit size :
10 ug
description :
The Recombinant Human PSMA/FOLH1 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human PSMA/FOLH1 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
PSMA/FOLH1/NAALADase I
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
110 kDa, reducing conditions
theoretical molecular weight :
80 kDa
gene symbol :
FOLH1
details of functionality :
Measured by its ability to hydrolyze the substrate N-acetyl-L-Asp-L-Glu into N-acetyl-L-Asp and L-Glu. The L-Glu product is measured by fluorescence after its derivatization by ortho -phthaldialdehyde. The specific activity is 400 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q04609
applications :
Enzyme Activity
source long :
Chinese Hamster Ovary cell line, CHO-derived human PSMA/FOLH1/NAALADase I protein Lys44-Ala750, with an N-terminal 6-His tag
source short :
CHO
USD :
432 USD
alt names :
Cell growth-inhibiting gene 27 protein, cell growth-inhibiting protein 27, EC 3.4.17.21, FGCP, folate hydrolase (prostate-specific membrane antigen) 1, Folate hydrolase 1, FOLH1, FOLHNAALADase I, Folylpoly-gamma-glutamate carboxypeptidase, GCP2, GCPII, GCPIImGCP, glutamate carboxylase II, glutamate carboxypeptidase 2, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, mopsm, NAALAD1, NAALAD1N-acetylated-alpha-linked acidic dipeptidase I, NAALAdase, NAALADase I, N-acetylated alpha-linked acidic dipeptidase 1, prostate specific membrane antigen variant F, Prostate-specific membrane antigen, PSMAFGCP, PSMPteroylpoly-gamma-glutamate carboxypeptidase
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.