Recombinant Human/Mouse FGF-8b Protein | R&D Systems 423-F8 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human/Mouse FGF-8b Protein

catalog :

423-F8

quantity :

1 mg

price :

3200 USD

citations: 47

Reference
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Elkouris M, Kouroupi G, Vourvoukelis A, Papagiannakis N, Kaltezioti V, Matsas R, et al. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients. Front Cell Neurosci. 2019;13:58 pubmed publisher
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Collo G, Cavalleri L, Zoli M, Maskos U, Ratti E, Merlo Pich E. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons. Front Pharmacol. 2018;9:572 pubmed publisher
Hu X, Lee J, Zheng X, Zhang J, Lin X, Song Y, et al. Efficient induction of functional ameloblasts from human keratinocyte stem cells. Stem Cell Res Ther. 2018;9:126 pubmed publisher
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Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi R, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018;2018:4196961 pubmed publisher
Shall G, Menosky M, Decker S, Nethala P, Welchko R, Lévêque X, et al. Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2018;19: pubmed publisher
Ruzo A, Croft G, Metzger J, Galgoczi S, Gerber L, Pellegrini C, et al. Chromosomal instability during neurogenesis in Huntington's disease. Development. 2018;145: pubmed publisher
Johansen T, Krabbe C, Schmidt S, Serrano A, Meyer M. Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells. Stem Cells Int. 2017;2017:9605432 pubmed publisher
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed publisher
Liddelow S, Guttenplan K, Clarke L, Bennett F, Bohlen C, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481-487 pubmed publisher
Stanslowsky N, Reinhardt P, Glass H, Kalmbach N, Naujock M, Hensel N, et al. Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization. J Neurosci. 2016;36:12027-12043 pubmed
Fresco V, Kern C, Mohammadi M, Twal W. Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL. J Biol Chem. 2016;291:18730-9 pubmed publisher
Monti D, Zabrecky G, Kremens D, Liang T, Wintering N, Cai J, et al. N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data. PLoS ONE. 2016;11:e0157602 pubmed publisher
Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, et al. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Sci Rep. 2016;6:26448 pubmed publisher
Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, et al. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS ONE. 2015;10:e0130147 pubmed publisher
Shen S, Shen C, Lin H, Chen C, Chang C, Chen S, et al. Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection. PLoS ONE. 2014;9:e114990 pubmed publisher
Attia L, Schneider J, Yelin R, Schultheiss T. Collective cell migration of the nephric duct requires FGF signaling. Dev Dyn. 2015;244:157-67 pubmed publisher
Yamamoto Shiraishi Y, Higuchi H, Yamamoto S, Hirano M, Kuroiwa A. Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal. Dev Biol. 2014;394:181-90 pubmed publisher
Lewandowski J, Pursell T, Rabinowitz A, Vokes S. Manipulating gene expression and signaling activity in cultured mouse limb bud cells. Dev Dyn. 2014;243:928-36 pubmed publisher
Mong J, Panman L, Alekseenko Z, Kee N, Stanton L, Ericson J, et al. Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells. Stem Cells. 2014;32:609-22 pubmed publisher
Ni N, Hu Y, Ren H, Luo C, Li P, Wan J, et al. Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. PLoS ONE. 2013;8:e84504 pubmed publisher
McCarroll M, Nechiporuk A. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PLoS ONE. 2013;8:e85087 pubmed publisher
Stappert L, Borghese L, Roese Koerner B, Weinhold S, Koch P, Terstegge S, et al. MicroRNA-based promotion of human neuronal differentiation and subtype specification. PLoS ONE. 2013;8:e59011 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
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Nimmagadda S, Geetha Loganathan P, Scaal M, Christ B, Huang R. FGFs, Wnts and BMPs mediate induction of VEGFR-2 (Quek-1) expression during avian somite development. Dev Biol. 2007;305:421-9 pubmed
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
Shimizu T, Bae Y, Hibi M. Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development. 2006;133:4709-19 pubmed
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed
Tiecke E, Bangs F, Blaschke R, Farrell E, Rappold G, Tickle C. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev Biol. 2006;298:585-96 pubmed
Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, et al. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death. J Neurochem. 2006;98:45-56 pubmed
Hutson M, Zhang P, Stadt H, Sato A, Li Y, Burch J, et al. Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Dev Biol. 2006;295:486-97 pubmed
Castelo Branco G, Sousa K, Bryja V, Pinto L, Wagner J, Arenas E. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol Cell Neurosci. 2006;31:251-62 pubmed
Delfini M, Dubrulle J, Malapert P, Chal J, Pourquie O. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc Natl Acad Sci U S A. 2005;102:11343-8 pubmed
Reversade B, Kuroda H, Lee H, Mays A, De Robertis E. Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development. 2005;132:3381-92 pubmed
Perrier A, Tabar V, Barberi T, Rubio M, Bruses J, Topf N, et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A. 2004;101:12543-8 pubmed
Wiellette E, Sive H. vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Development. 2003;130:3821-9 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed
Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int J Dev Biol. 2003;47:15-29 pubmed
Fischer A, Viebahn C, Blum M. FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr Biol. 2002;12:1807-16 pubmed
Abu Issa R, Smyth G, Smoak I, Yamamura K, Meyers E. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002;129:4613-25 pubmed
Alsan B, Schultheiss T. Regulation of avian cardiogenesis by Fgf8 signaling. Development. 2002;129:1935-43 pubmed

product information

brand :

R&D Systems

master code :

423-F8

SKU :

423-F8-01M

product name :

Recombinant Human/Mouse FGF-8b Protein

description :

The Recombinant Human/Mouse FGF-8b Protein from R&D Systems is derived from E. coli. The Recombinant Human/Mouse FGF-8b Protein has been validated for the following applications: Bioactivity.

target :

FGF-8

category :

Proteins and Enzymes

unit size :

1 mg

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4 and Brij-35 with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human, Mouse

observed molecular weight :

23 kDa, reducing conditions

theoretical molecular weight :

22.5 kDa

gene symbol :

FGF8

details of functionality :

Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is typically 6.5-40 ng/mL in the presence of 1 µg/mL heparin.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

423-F8

accessionNumbers :

NP_006110 (human), NP_001159834 (mouse)

applications :

Bioactivity

source :

E. coli -derived FGF-8 protein Gln23-Arg215, with an N-terminal Met

2020 USD :

3200

2021 USD :

3200 USD

alt names :

AIGF, AIGFKAL6, Androgen-induced growth factor, FGF8, FGF-8, fibroblast growth factor 8, fibroblast growth factor 8 (androgen-induced), HBGF-8, Heparin-binding growth factor 8, MGC149376

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.