This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-17A Protein
catalog :
421-ML-025
quantity :
25 ug
price :
291 USD
citations: 92
Reference
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Mancini A, Tantucci M, Mazzocchetti P, de Iure A, Durante V, Macchioni L, et al. Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis. Neurobiol Dis. 2018;113:97-108 pubmed publisher
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Maeda Y, Farina N, Matzelle M, Fanning P, Lian J, Gravallese E. Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis. J Bone Miner Res. 2017;32:461-472 pubmed publisher
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Miljković D, Blaževski J, Petković F, Djedović N, Momčilović M, Stanisavljević S, et al. A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. J Immunol. 2015;194:2493-503 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Dallenbach K, Maurer P, Röhn T, Zabel F, Kopf M, Bachmann M. Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease. Eur J Immunol. 2015;45:1238-47 pubmed publisher
Ha H, Wang H, Pisitkun P, Kim J, Tassi I, Tang W, et al. IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Proc Natl Acad Sci U S A. 2014;111:E3422-31 pubmed publisher
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Ardeljan D, Wang Y, Park S, Shen D, Chu X, Yu C, et al. Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration. PLoS ONE. 2014;9:e95900 pubmed publisher
Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, et al. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gin. J Biol Chem. 2014;289:15621-30 pubmed publisher
Carrillo Salinas F, Navarrete C, Mecha M, Feliú A, Collado J, Cantarero I, et al. A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis. PLoS ONE. 2014;9:e94733 pubmed publisher
Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben Addi A, et al. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. J Immunol. 2014;192:3518-3529 pubmed publisher
Yang E, Lee J, Lee S, Kim E, Moon Y, Jung Y, et al. EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1? with Th17/Treg control. PLoS ONE. 2014;9:e86062 pubmed publisher
Moon C, VanDussen K, Miyoshi H, Stappenbeck T. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol. 2014;7:818-28 pubmed publisher
Hwang I, Hwang K, Park C, Harrison K, Kehrl J. Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE. 2013;8:e60139 pubmed publisher
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Sadik C, Kim N, Alekseeva E, Luster A. IL-17RA signaling amplifies antibody-induced arthritis. PLoS ONE. 2011;6:e26342 pubmed publisher
Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, et al. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice. J Immunol. 2011;187:4818-25 pubmed publisher
Whitehead G, Wilson R, Nakano K, Burch L, Nakano H, Cook D. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol. 2012;129:207-15.e1-5 pubmed publisher
Li Z, Burns A, Han L, Rumbaut R, Smith C. IL-17 and VEGF are necessary for efficient corneal nerve regeneration. Am J Pathol. 2011;178:1106-16 pubmed publisher
Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, et al. IL-17A and TNF-? exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011;186:3197-205 pubmed publisher
Kagami S, Rizzo H, Kurtz S, Miller L, Blauvelt A. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol. 2010;185:5453-62 pubmed publisher
Wondimu Z, Santodomingo Garzon T, Le T, Swain M. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am J Pathol. 2010;177:2334-46 pubmed publisher
Blumberg H, Dinh H, Dean C, Trueblood E, Bailey K, Shows D, et al. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J Immunol. 2010;185:4354-62 pubmed publisher
Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol. 2010;185:2502-15 pubmed publisher
Cho J, Pietras E, Garcia N, Ramos R, Farzam D, Monroe H, et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010;120:1762-73 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke R, et al. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. Infect Immun. 2010;78:830-7 pubmed publisher
Moransard M, Sawitzky M, Fontana A, Suter T. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis. Glia. 2010;58:559-71 pubmed publisher
Meeks K, Sieve A, Kolls J, Ghilardi N, Berg R. IL-23 is required for protection against systemic infection with Listeria monocytogenes. J Immunol. 2009;183:8026-34 pubmed publisher
Oyoshi M, Elkhal A, Kumar L, Scott J, Koduru S, He R, et al. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009;106:14954-9 pubmed publisher
Wilson R, Whitehead G, Nakano H, Free M, Kolls J, Cook D. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009;180:720-30 pubmed publisher
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton M, et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol. 2009;183:1291-300 pubmed publisher
Freitas A, Alves Filho J, Victoni T, Secher T, Lemos H, Sonego F, et al. IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol. 2009;182:7846-54 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, et al. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun. 2009;382:252-8 pubmed publisher
Ozment Skelton T, deFluiter E, Ha T, Li C, Graves B, Ferguson D, et al. Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Crit Care Med. 2009;37:1038-45 pubmed publisher
Swaidani S, Bulek K, Kang Z, Liu C, Lu Y, Yin W, et al. The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation. J Immunol. 2009;182:1631-40 pubmed
Claudio E, Sønder S, Saret S, Carvalho G, Ramalingam T, Wynn T, et al. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol. 2009;182:1617-30 pubmed
Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009;30:108-19 pubmed publisher
Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, et al. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res. 2009;19:208-15 pubmed publisher
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D Acquisto F. Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol. 2009;77:878-87 pubmed publisher
Nagata T, McKinley L, Peschon J, Alcorn J, Aujla S, Kolls J. Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells. J Immunol. 2008;181:7473-9 pubmed
Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, et al. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J Invest Dermatol. 2009;129:650-6 pubmed publisher
Rickel E, Siegel L, Yoon B, Rottman J, Kugler D, Swart D, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008;181:4299-310 pubmed
Da Silva C, Hartl D, Liu W, Lee C, Elias J. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol. 2008;181:4279-86 pubmed
Furze R, Rankin S. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 2008;22:3111-9 pubmed publisher
Guo B, Chang E, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest. 2008;118:1680-90 pubmed publisher
Van De Wiele C, Marino J, Tan C, Kneale H, Weber J, Morelli J, et al. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 2007;250:31-9 pubmed publisher
Aujla S, Chan Y, Zheng M, Fei M, Askew D, Pociask D, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med. 2008;14:275-81 pubmed publisher
Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol. 2007;37:2695-706 pubmed
Sheibanie A, Yen J, Khayrullina T, Emig F, Zhang M, Tuma R, et al. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J Immunol. 2007;178:8138-47 pubmed
Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, et al. Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum. Kidney Int. 2007;71:514-25 pubmed
Nakae S, Suto H, Berry G, Galli S. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood. 2007;109:3640-8 pubmed
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Jovcic G, Bugarski D, Petakov M, Krstic A, Vlaski M, Stojanovic N, et al. In vivo effects of interleukin-17 on haematopoietic cells and cytokine release in normal mice. Cell Prolif. 2004;37:401-12 pubmed
Burchill M, Nardelli D, England D, DeCoster D, Christopherson J, Callister S, et al. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect Immun. 2003;71:3437-42 pubmed
Miyamoto M, Prause O, Sjöstrand M, Laan M, Lotvall J, Linden A. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J Immunol. 2003;170:4665-72 pubmed
product information
master code :
421-ML
SKU :
421-ML-025
product name :
Recombinant Mouse IL-17A Protein
unit size :
25 ug
description :
The Recombinant Mouse IL-17A Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-17A Protein has been validated for the following applications: Bioactivity.
target :
IL-17/IL-17A
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
15.5 kDa (monomer)
gene symbol :
Il17a
details of functionality :
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al . (1995) Immunity 3 :811. The ED50 for this effect is 0.25-1.25 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q62386.1
applications :
Bioactivity
source long :
E. coli -derived mouse IL-17/IL-17A protein Thr22-Ala158
source short :
E. coli
USD :
291 USD
alt names :
CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.