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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-17A Protein
catalog :
421-ML-025
quantity :
25 ug
price :
239 USD
more info or order :
citations: 77
Reference
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Hsu D, Taylor P, Fletcher D, van Heeckeren R, Eastman J, Van Heeckeren A, et al. Interleukin-17 Pathophysiology and Therapeutic Intervention in Cystic Fibrosis Lung Infection and Inflammation. Infect Immun. 2016;84:2410-21 pubmed publisher
Lim J, Im K, Lee E, Kim N, Nam Y, Jeon Y, et al. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis. Sci Rep. 2016;6:26851 pubmed publisher
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Ha H, Wang H, Pisitkun P, Kim J, Tassi I, Tang W, et al. IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Proc Natl Acad Sci U S A. 2014;111:E3422-31 pubmed publisher
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Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, et al. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gin. J Biol Chem. 2014;289:15621-30 pubmed publisher
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Sadik C, Kim N, Alekseeva E, Luster A. IL-17RA signaling amplifies antibody-induced arthritis. PLoS ONE. 2011;6:e26342 pubmed publisher
Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, et al. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice. J Immunol. 2011;187:4818-25 pubmed publisher
Whitehead G, Wilson R, Nakano K, Burch L, Nakano H, Cook D. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol. 2012;129:207-15.e1-5 pubmed publisher
Li Z, Burns A, Han L, Rumbaut R, Smith C. IL-17 and VEGF are necessary for efficient corneal nerve regeneration. Am J Pathol. 2011;178:1106-16 pubmed publisher
Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, et al. IL-17A and TNF-? exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011;186:3197-205 pubmed publisher
Kagami S, Rizzo H, Kurtz S, Miller L, Blauvelt A. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol. 2010;185:5453-62 pubmed publisher
Wondimu Z, Santodomingo Garzon T, Le T, Swain M. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am J Pathol. 2010;177:2334-46 pubmed publisher
Blumberg H, Dinh H, Dean C, Trueblood E, Bailey K, Shows D, et al. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J Immunol. 2010;185:4354-62 pubmed publisher
Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol. 2010;185:2502-15 pubmed publisher
Cho J, Pietras E, Garcia N, Ramos R, Farzam D, Monroe H, et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010;120:1762-73 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke R, et al. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. Infect Immun. 2010;78:830-7 pubmed publisher
Moransard M, Sawitzky M, Fontana A, Suter T. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis. Glia. 2010;58:559-71 pubmed publisher
Meeks K, Sieve A, Kolls J, Ghilardi N, Berg R. IL-23 is required for protection against systemic infection with Listeria monocytogenes. J Immunol. 2009;183:8026-34 pubmed publisher
Oyoshi M, Elkhal A, Kumar L, Scott J, Koduru S, He R, et al. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009;106:14954-9 pubmed publisher
Wilson R, Whitehead G, Nakano H, Free M, Kolls J, Cook D. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009;180:720-30 pubmed publisher
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton M, et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol. 2009;183:1291-300 pubmed publisher
Freitas A, Alves Filho J, Victoni T, Secher T, Lemos H, Sonego F, et al. IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol. 2009;182:7846-54 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, et al. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun. 2009;382:252-8 pubmed publisher
Ozment Skelton T, deFluiter E, Ha T, Li C, Graves B, Ferguson D, et al. Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Crit Care Med. 2009;37:1038-45 pubmed publisher
Swaidani S, Bulek K, Kang Z, Liu C, Lu Y, Yin W, et al. The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation. J Immunol. 2009;182:1631-40 pubmed
Claudio E, Sønder S, Saret S, Carvalho G, Ramalingam T, Wynn T, et al. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol. 2009;182:1617-30 pubmed
Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009;30:108-19 pubmed publisher
Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, et al. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res. 2009;19:208-15 pubmed publisher
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D Acquisto F. Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol. 2009;77:878-87 pubmed publisher
Nagata T, McKinley L, Peschon J, Alcorn J, Aujla S, Kolls J. Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells. J Immunol. 2008;181:7473-9 pubmed
Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, et al. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J Invest Dermatol. 2009;129:650-6 pubmed publisher
Rickel E, Siegel L, Yoon B, Rottman J, Kugler D, Swart D, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008;181:4299-310 pubmed
Da Silva C, Hartl D, Liu W, Lee C, Elias J. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol. 2008;181:4279-86 pubmed
Furze R, Rankin S. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 2008;22:3111-9 pubmed publisher
Guo B, Chang E, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest. 2008;118:1680-90 pubmed publisher
Van De Wiele C, Marino J, Tan C, Kneale H, Weber J, Morelli J, et al. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 2007;250:31-9 pubmed publisher
Aujla S, Chan Y, Zheng M, Fei M, Askew D, Pociask D, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med. 2008;14:275-81 pubmed publisher
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Sheibanie A, Yen J, Khayrullina T, Emig F, Zhang M, Tuma R, et al. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J Immunol. 2007;178:8138-47 pubmed
Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, et al. Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum. Kidney Int. 2007;71:514-25 pubmed
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Burchill M, Nardelli D, England D, DeCoster D, Christopherson J, Callister S, et al. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect Immun. 2003;71:3437-42 pubmed
Miyamoto M, Prause O, Sjöstrand M, Laan M, Lotvall J, Linden A. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J Immunol. 2003;170:4665-72 pubmed
product information
brand :
R&D Systems
master code :
421-ML
SKU :
421-ML-025
product name :
Recombinant Mouse IL-17A Protein
description :
The IL-17/IL-17A Protein from 421-ML-025 is derived from E. coli-derived Recombinant Mouse IL-17A Protein. The IL-17/IL-17A Protein has been validated for the following applications: Q62386.1.
target :
IL-17/IL-17A
category :
Proteins and Enzymes
unit sizes :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
15.5 kDa (monomer)
gene symbol :
Il17a
details of functionality :
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al . (1995) Immunity 3 :811. The ED50 for this effect is 0.25-1.25 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62386.1
applications :
Bioactivity
extended description :
A New and Improved rm IL-17A is now available! It is CHO expressed and has a lower endotoxin specification!
source :
E. coli-derived Recombinant Mouse IL-17A Protein
USD :
239 USD
product details :
A New and Improved rm IL-17A is now available! It is CHO expressed and has a lower endotoxin specification!
alt names :
CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.