Recombinant Mouse CCL11/Eotaxin Protein, CF | R&D Systems 420-ME-020/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CCL11/Eotaxin Protein, CF

catalog :

420-ME-020/CF

quantity :

20 ug (also 100 ug)

price :

300 USD

citations: 15

Reference
Scabia G, Testa G, Scali M, Del Turco S, Desiato G, Berardi N, et al. Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus. Brain Behav Immun. 2021;98:234-244 pubmed publisher
Boscolo Sesillo F, Fox D, Sacco A. Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy. Cell Rep. 2019;26:689-701.e6 pubmed publisher
Kindstedt E, Holm C, Sulniute R, Martinez Carrasco I, Lundmark R, Lundberg P. CCL11, a novel mediator of inflammatory bone resorption. Sci Rep. 2017;7:5334 pubmed publisher
Erickson M, Morofuji Y, Owen J, Banks W. Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells. J Pharmacol Exp Ther. 2014;349:497-507 pubmed publisher
Villeda S, Luo J, Mosher K, Zou B, Britschgi M, Bieri G, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011;477:90-4 pubmed publisher
Nel H, Hams E, Saunders S, Mangan N, Smith P, Atzberger A, et al. Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. J Immunol. 2011;186:4631-9 pubmed publisher
Kearley J, Buckland K, Mathie S, Lloyd C. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med. 2009;179:772-81 pubmed publisher
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
De Lucca G, Kim U, Vargo B, Duncia J, Santella J, Gardner D, et al. Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem. 2005;48:2194-211 pubmed
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed
Reading P, Symons J, Smith G. A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection. J Immunol. 2003;170:1435-42 pubmed
Larbi K, Dangerfield J, Culley F, Marshall D, Haskard D, Jose P, et al. P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J Leukoc Biol. 2003;73:65-73 pubmed
Wan Y, Jakway J, Qiu H, Shah H, Garlisi C, Tian F, et al. Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002;456:1-10 pubmed
Lukacs N, Berlin A, Schols D, Skerlj R, Bridger G. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am J Pathol. 2002;160:1353-60 pubmed

product information

master code :

420-ME/CF

SKU :

420-ME-020/CF

product name :

Recombinant Mouse CCL11/Eotaxin Protein, CF

unit size :

20 ug (also 100 ug)

description :

The Recombinant Mouse CCL11/Eotaxin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse CCL11/Eotaxin Protein, CF has been validated for the following applications: Bioactivity.

target :

CCL11/Eotaxin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

8.4 kDa

gene symbol :

Ccl11

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CCR3. The ED50 for this effect is 1-5áng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P48298

applications :

Bioactivity

source long :

E. coli -derived mouse CCL11/Eotaxin protein His24-Pro97

source short :

E. coli

USD :

300 USD

alt names :

C-C motif chemokine 11, chemokine (C-C motif) ligand 11, Eosinophil chemotactic protein, Eotaxin, eotaxin-1, MGC22554, SCYA11Small-inducible cytokine A11, small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.