Recombinant Mouse IL-11 Protein | R&D Systems 418-ML-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-11 Protein

catalog :

418-ML-025

quantity :

25 ug

price :

1088 USD

citations: 26

Reference
Wu J, Krchma K, Lee H, Prabhakar S, Wang X, Zhao H, et al. Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Cell Rep. 2020;33:108395 pubmed publisher
Zhang X, Kiapour N, Kapoor S, Khan T, Thamilarasan M, Tao Y, et al. IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. J Immunol. 2019;203:1142-1150 pubmed publisher
Delás M, Jackson B, Kovacević T, Vangelisti S, Munera Maravilla E, Wild S, et al. lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation. Cell Rep. 2019;27:719-729.e6 pubmed publisher
Wilson K, Kang I, Baliga U, Xiong Y, Chatterjee S, Moore E, et al. Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells. Sci Rep. 2018;8:8026 pubmed publisher
Dahlin J, Hamey F, Pijuan Sala B, Shepherd M, Lau W, Nestorowa S, et al. A single cell hematopoietic landscape resolves eight lineage trajectories and defects in Kit mutant mice. Blood. 2018;: pubmed publisher
Draper J, Sroczynska P, Fadlullah M, Patel R, Newton G, Breitwieser W, et al. A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects. PLoS Genet. 2018;14:e1007127 pubmed publisher
Ollila S, Domènech Moreno E, Laajanen K, Wong I, Tripathi S, Pentinmikko N, et al. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. J Clin Invest. 2018;128:402-414 pubmed publisher
Shukla S, Langley M, Singh J, Edgar J, Mohtashami M, Zuniga Pflucker J, et al. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods. 2017;14:531-538 pubmed publisher
Ruf F, Schreck C, Wagner A, Grziwok S, Pagel C, Romero S, et al. Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool. Stem Cells. 2016;34:2381-92 pubmed publisher
Tengvall S, Eneljung T, Jirholt P, Turesson O, Wing K, Holmdahl R, et al. Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis. PLoS ONE. 2016;11:e0154630 pubmed publisher
Seto D, Kandarian S, Jackman R. A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem. 2015;290:19976-86 pubmed publisher
Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, et al. CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor. Stem Cells. 2015;33:976-87 pubmed publisher
Figueiredo C, Drohomyrecky P, McCarthy S, Leontyev D, Ma X, Branch D, et al. Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor. PLoS ONE. 2014;9:e101947 pubmed publisher
Carnevalli L, Scognamiglio R, Cabezas Wallscheid N, Rahmig S, Laurenti E, Masuda K, et al. Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med. 2014;211:769-79 pubmed publisher
Verovskaya E, Broekhuis M, Zwart E, Weersing E, Ritsema M, Bosman L, et al. Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines. J Exp Med. 2014;211:487-97 pubmed publisher
Elsaeidi F, Bemben M, Zhao X, Goldman D. Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. J Neurosci. 2014;34:2632-44 pubmed publisher
Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, et al. Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports. 2013;1:545-59 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Cook B, Liu S, Evans T. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood. 2011;117:6489-97 pubmed publisher
Mitchell H, White D, Domowicz M, Kraig R. Cold pre-conditioning neuroprotection depends on TNF-? and is enhanced by blockade of interleukin-11. J Neurochem. 2011;117:187-96 pubmed publisher
Stumhofer J, Tait E, Quinn W, Hosken N, Spudy B, Goenka R, et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol. 2010;11:1119-26 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, et al. Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal. 2009;21:151-60 pubmed publisher
Zhang Y, Taveggia C, MELENDEZ VASQUEZ C, Einheber S, Raine C, Salzer J, et al. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J Neurosci. 2006;26:12174-85 pubmed
Braun B, Archard J, Van Ziffle J, Tuveson D, Jacks T, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006;108:2041-4 pubmed
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M. The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch Dermatol Res. 2001;293:508-14 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

418-ML

SKU :

418-ML-025

product name :

Recombinant Mouse IL-11 Protein

Description :

The Recombinant Mouse IL-11 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-11 Protein has been validated for the following applications: Bioactivity.

target :

IL-11

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Sodium Succinate, Mannitol and Tween® 80 with Trehalose and with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

theoretical molecular weight :

19 kDa

gene symbol :

Il11

details of functionality :

Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. Nordan, R.P. et al . (1987) J. Immunol. 139 :813. The ED50 for this effect is 0.04-0.4 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P47873

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse IL-11 Protein

USD :

1088 USD

alt names :

Adipogenesis inhibitory factor, AGIF, AGIFoprelvekin, IL11, IL-11Oprelvekin, interleukin 11, interleukin-11, Oprelvekin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.