Recombinant Human Integrin alpha V beta 8 Protein, CF | R&D Systems 4135-AV-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha V beta 8 Protein, CF

catalog :

4135-AV-050

quantity :

50 ug

price :

503 USD

citations: 6

Reference
Bieri M, Hendrickx R, Bauer M, Yu B, Jetzer T, Dreier B, et al. The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathog. 2021;17:e1010083 pubmed publisher
Dodagatta Marri E, Ma H, Liang B, Li J, Meyer D, Chen S, et al. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021;36:109309 pubmed publisher
Whilding L, Parente Pereira A, Zabinski T, Davies D, Petrovic R, Kao Y, et al. Targeting of Aberrant Î±vÎ²6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells. Mol Ther. 2017;25:259-273 pubmed publisher
Tsui P, Higazi D, Wu Y, Dunmore R, Solier E, Kasali T, et al. The TGF-? inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan. MAbs. 2017;9:104-113 pubmed publisher
Barbariga M, Curnis F, Spitaleri A, Andolfo A, Zucchelli C, Lazzaro M, et al. Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signaling. J Biol Chem. 2014;289:3736-48 pubmed publisher
Curnis F, Cattaneo A, Longhi R, Sacchi A, Gasparri A, Pastorino F, et al. Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching. J Biol Chem. 2010;285:9114-23 pubmed publisher

product information

master code :

4135-AV

SKU :

4135-AV-050

product name :

Recombinant Human Integrin alpha V beta 8 Protein, CF

unit size :

50 ug

description :

The Recombinant Human Integrin alpha V beta 8 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha V beta 8 Protein, CF has been validated for the following applications: Binding Activity.

target :

Integrin alpha V beta 8

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris, NaCl and MgCl2.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

130-155 kDa and 85-100 kDa, reducing conditions

theoretical molecular weight :

110.5 kDa ( alpha V subunit), 75.3 kDa (▀8 subunit)

gene symbol :

ITGAV

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Integrin alpha V▀8 at 2 ╡g/mL can bind recombinant human Lap with an apparent Kd 0.5 nM.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

top caption :

Graph showing bioactivity of Human Integrin alpha V beta 8 protein

accessionNumbers :

NP_002201.1 (Integrin alpha V) P26012.1 (Integrin ▀8)

applications :

Binding Activity

source long :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha V beta 8 protein Human Integrin alpha V (Phe31-Val992) Accession # NP_002201.1 His-Pro GGGSGGGS Acidic Tail Human Integrin ▀8 (Glu43-Arg684) Accession # P26012.1 His-Pro GGGSGGGS Basic Tail N-terminus C-terminus

source short :

CHO

USD :

503 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 2 weeks, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.