Recombinant Human Integrin alpha V beta 8 Protein, CF | R&D Systems 4135-AV-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha V beta 8 Protein, CF

catalog :

4135-AV-050

quantity :

50 ug

price :

503 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Bieri M, Hendrickx R, Bauer M, Yu B, Jetzer T, Dreier B, et al. The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathog. 2021;17:e1010083 pubmed publisher
Dodagatta Marri E, Ma H, Liang B, Li J, Meyer D, Chen S, et al. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021;36:109309 pubmed publisher
Tsui P, Higazi D, Wu Y, Dunmore R, Solier E, Kasali T, et al. The TGF-? inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan. MAbs. 2017;9:104-113 pubmed publisher
Barbariga M, Curnis F, Spitaleri A, Andolfo A, Zucchelli C, Lazzaro M, et al. Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signaling. J Biol Chem. 2014;289:3736-48 pubmed publisher
Curnis F, Cattaneo A, Longhi R, Sacchi A, Gasparri A, Pastorino F, et al. Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching. J Biol Chem. 2010;285:9114-23 pubmed publisher

image

image 1 :

Graph showing bioactivity of Human Integrin alpha V beta 8 protein

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

4135-AV

SKU :

4135-AV-050

product name :

Recombinant Human Integrin alpha V beta 8 Protein, CF

description :

The Recombinant Human Integrin alpha V beta 8 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha V beta 8 Protein, CF has been validated for the following applications: Binding Activity.

target :

Integrin alpha V beta 8

unit size :

50 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and MgCl2.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 2 weeks, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

130-155 kDa and 85-100 kDa, reducing conditions

theoretical molecular weight :

110.5 kDa ( alpha V subunit), 75.3 kDa (ß8 subunit)

gene symbol :

ITGAV

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Integrin alpha Vß8 at 2 µg/mL can bind recombinant human Lap with an apparent Kd 0.5 nM.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_002201.1 (Integrin alpha V) P26012.1 (Integrin ß8)

applications :

Binding Activity

product keywords :

4135-AV, rhIntegin aVb8, hIntegin aVb8, carrier-free, carrier free, 4135AV, Integrin V 8, Integrin V 8, Integrin alfa V beta 8, Integrin aVss8, Integrin aVb8, Integrin-aVb8, ITGA2B8, ITGB8A2, Integrin alphaVbeta8, Integrin aVb8, Integrin beta8, Integrinbeta8, Integrin b8, Integrinb8

source :

CHO-derived Recombinant Human Integrin alpha V beta 8 Protein, CF

USD :

493

USD 2025 :

503 USD

more info or order :

R&D Systems product webpage