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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-13 Protein
catalog :
413-ML-005
quantity :
5 ug (also 25 ug, 50 ug, 100 ug, 250 ug)
price :
359 USD
more info or order :
citations: 87
Reference
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Wu K, Byers D, Jin X, Agapov E, Alexander Brett J, Patel A, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med. 2015;212:681-97 pubmed publisher
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Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, et al. IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. J Immunol. 2015;194:1894-904 pubmed publisher
Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, et al. Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol. 2014;193:1717-27 pubmed publisher
Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, et al. I?B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014;193:1184-93 pubmed publisher
Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol. 2014;192:3569-81 pubmed publisher
Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, et al. S100A8 induces IL-10 and protects against acute lung injury. J Immunol. 2014;192:2800-11 pubmed publisher
Veremeyko T, Siddiqui S, Sotnikov I, Yung A, Ponomarev E. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE. 2013;8:e81774 pubmed publisher
Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity. 2013;39:976-85 pubmed publisher
Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, et al. Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Kidney Int. 2014;85:794-806 pubmed publisher
McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A, Schuchmann M, et al. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity. 2013;39:357-71 pubmed publisher
Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, et al. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep. 2013;3:1540 pubmed publisher
Starkey M, Essilfie A, Horvat J, Kim R, Nguyen D, Beagley K, et al. Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease. Mucosal Immunol. 2013;6:569-79 pubmed publisher
Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, et al. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 2012;189:3641-52 pubmed
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Monticelli L, Sonnenberg G, Abt M, Alenghat T, Ziegler C, Doering T, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12:1045-54 pubmed publisher
Taube C, Tertilt C, Gyülveszi G, Dehzad N, Kreymborg K, Schneeweiss K, et al. IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease. PLoS ONE. 2011;6:e21799 pubmed publisher
Oh M, Oh S, Yu J, Myers A, Leonard W, Liu Y, et al. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol. 2011;186:7232-42 pubmed publisher
Asquith K, Horvat J, Kaiko G, Carey A, Beagley K, Hansbro P, et al. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog. 2011;7:e1001339 pubmed publisher
Sehra S, Yao W, Nguyen E, Ahyi A, Tuana F, Ahlfeld S, et al. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011;186:4959-66 pubmed publisher
Zhao A, Urban J, Sun R, Stiltz J, Morimoto M, Notari L, et al. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol. 2010;185:6921-9 pubmed publisher
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Mosconi E, Rekima A, Seitz Polski B, Kanda A, Fleury S, Tissandie E, et al. Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol. 2010;3:461-74 pubmed publisher
Horvat J, Starkey M, Kim R, Beagley K, Preston J, Gibson P, et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol. 2010;184:4159-69 pubmed publisher
Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, et al. Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol. 2009;39:3078-83 pubmed publisher
Neveu W, Allard J, Dienz O, Wargo M, Ciliberto G, Whittaker L, et al. IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol. 2009;183:1732-8 pubmed publisher
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Hudson C, Christophi G, Gruber R, Wilmore J, Lawrence D, Massa P. Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol. 2008;84:631-43 pubmed publisher
Miller R, Sadhukhan R, Wu C. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J Immunol Methods. 2008;334:134-41 pubmed publisher
Khaled W, Read E, Nicholson S, Baxter F, Brennan A, Came P, et al. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development. 2007;134:2739-50 pubmed
Lama V, Harada H, Badri L, Flint A, Hogaboam C, McKenzie A, et al. Obligatory role for interleukin-13 in obstructive lesion development in airway allografts. Am J Pathol. 2006;169:47-60 pubmed
Wen H, Hogaboam C, Gauldie J, Kunkel S. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am J Pathol. 2006;168:1940-50 pubmed
Howell M, Gallo R, Boguniewicz M, Jones J, Wong C, Streib J, et al. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity. 2006;24:341-8 pubmed
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Jakubzick C, Choi E, Kunkel S, Joshi B, Puri R, Hogaboam C. Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am J Pathol. 2003;162:1475-86 pubmed
Herrick C, Xu L, McKenzie A, Tigelaar R, Bottomly K. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J Immunol. 2003;170:2488-95 pubmed
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Shi Z, Fischer M, De Sanctis G, Schuyler M, Tesfaigzi Y. IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. J Immunol. 2002;168:4764-71 pubmed
image
image 1 :
R&D Systems 413-ML-005 image 1
Recombinant Mouse IL-13 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
413-ML
SKU :
413-ML-005
product name :
Recombinant Mouse IL-13 Protein
Description :
The Recombinant Mouse IL-13 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-13 Protein has been validated for the following applications: Bioactivity.
target :
IL-13
category :
Proteins and Enzymes
unit size :
5 ug (also 25 ug, 50 ug, 100 ug, 250 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
9 kDa, reducing conditions
theoretical molecular weight :
11.5 kDa
gene symbol :
Il13
details of functionality :
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.75-3 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P20109
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse IL-13 Protein
USD :
359 USD
alt names :
ALRHMGC116789, BHR1interleukin-13, IL13, IL-13MGC116788, interleukin 13, MGC116786, NC30, P600
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.