Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF | R&D Systems 4119-GH-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF

catalog :

4119-GH-010

quantity :

10 ug

price :

541 USD

citations: 3

Reference
Laoharawee K, Podetz Pedersen K, Nguyen T, Singh S, Smith M, Belur L, et al. Non-invasive intravenous administration of AAV9 transducing iduronate sulfatase leads to global metabolic correction and prevention of neurologic deficits in a mouse model of Hunter syndrome. Mol Genet Metab Rep. 2023;34:100956 pubmed publisher
Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, et al. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death Dis. 2018;9:808 pubmed publisher
Laoharawee K, DeKelver R, Podetz Pedersen K, Rohde M, Sproul S, Nguyen H, et al. Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing. Mol Ther. 2018;26:1127-1136 pubmed publisher

product information

master code :

4119-GH

SKU :

4119-GH-010

product name :

Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF

unit size :

10 ug

description :

The Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF from R&D Systems is derived from NS0. The Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF has been validated for the following applications: Enzyme Activity.

target :

alpha-L-Iduronidase/IDUA

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Sodium Acetate, NaCl and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

83 kDa, reducing conditions

theoretical molecular weight :

71 kDa

gene symbol :

IDUA

details of functionality :

Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl alpha -L-iduronide. The specific activity is 7,500 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAA81589

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived human alpha-L-Iduronidase/IDUA protein Ala26-Pro653 (Ala26Thr), with a C-terminal 10-His tag

source short :

NS0

extended description :

NS0-expressed

USD :

541 USD

product details :

NS0-expressed

alt names :

alphaLIduronidase, IDA, IDUA, MPS1, MPSI

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.