product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TNF-alpha (aa 80-235) Protein
catalog :
410-MT-010
quantity :
10 ug
price :
226 USD
more info or order :
citations: 262
Reference
Stancic A, Saksida T, Markelic M, Vucetic M, Grigorov I, Martinović V, et al. Ferroptosis as a Novel Determinant of β-Cell Death in Diabetic Conditions. Oxid Med Cell Longev. 2022;2022:3873420 pubmed publisher
Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, et al. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling. elife. 2022;11: pubmed publisher
Cheng Y, Hall T, Xu X, Yung I, Souza D, Zheng J, et al. Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease. EBioMedicine. 2022;75:103758 pubmed publisher
Won M, Park K, Kim S, Ju E, Ko Y, Yoo H, et al. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Cell Death Differ. 2022;29:1152-1163 pubmed publisher
Zhang Y, Zheng Y, Shu F, Zhou R, Bao B, Xiao S, et al. In situ-formed adhesive hyaluronic acid hydrogel with prolonged amnion-derived conditioned medium release for diabetic wound repair. Carbohydr Polym. 2022;276:118752 pubmed publisher
Guo X, Bai J, Ge G, Wang Z, Wang Q, Zheng K, et al. Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis. J Colloid Interface Sci. 2022;605:410-424 pubmed publisher
Glasow A, Patties I, Priest N, Mitchel R, Hildebrandt G, Manda K. Dose and Dose Rate-Dependent Effects of Low-Dose Irradiation on Inflammatory Parameters in ApoE-Deficient and Wild Type Mice. Cells. 2021;10: pubmed publisher
Chauhan P, Sheng W, Hu S, Prasad S, Lokensgard J. Differential Cytokine-Induced Responses of Polarized Microglia. Brain Sci. 2021;11: pubmed publisher
Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, et al. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021;37:110037 pubmed publisher
Miyashita N, Enokido T, Horie M, Fukuda K, Urushiyama H, Strell C, et al. TGF-β-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma. Sci Rep. 2021;11:22380 pubmed publisher
Shi Y, Li S, Zhang H, Zhu J, Che T, Yan B, et al. The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons. J Neuroinflammation. 2021;18:261 pubmed publisher
Håland E, Moen I, Veidal E, Hella H, Misund K, Slørdahl T, et al. TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan. Oncotarget. 2021;12:2158-2168 pubmed publisher
Zhou T, DeRoo E, Yang H, Stranz A, Wang Q, Ginnan R, et al. MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis. Cells. 2021;10: pubmed publisher
Papazian I, Tsoukala E, Boutou A, Karamita M, Kambas K, Iliopoulou L, et al. Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. J Neuroinflammation. 2021;18:222 pubmed publisher
Pokharel S, Chiok K, Shil N, Mohanty I, Bose S. Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway. PLoS ONE. 2021;16:e0257576 pubmed publisher
Gluschko A, Farid A, Herb M, Grumme D, Kronke M, Schramm M. Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways. Autophagy. 2021;:1-18 pubmed publisher
Sumi K, Sakuda M, Munakata K, Nakamura K, Ashida K. α-Hydroxyisocaproic Acid Decreases Protein Synthesis but Attenuates TNFα/IFNγ Co-Exposure-Induced Protein Degradation and Myotube Atrophy via Suppression of iNOS and IL-6 in Murine C2C12 Myotube. Nutrients. 2021;13: pubmed publisher
Almutairi F, Tucker S, Sarr D, Rada B. PI3K/ NF-κB-dependent TNF-α and HDAC activities facilitate LPS-induced RGS10 suppression in pulmonary macrophages. Cell Signal. 2021;86:110099 pubmed publisher
Preda M, Neculachi C, Fenyo I, Vacaru A, Publik M, Simionescu M, et al. Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice. Cell Death Dis. 2021;12:566 pubmed publisher
Farré Alins V, Palomino Antolin A, Narros Fernández P, López Rodríguez A, Decouty Pérez C, Muñoz Montero A, et al. Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients. Biomedicines. 2021;9: pubmed publisher
Zhao J, Cai B, Shao Z, Zhang L, Zheng Y, Ma C, et al. TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1. Cell Death Differ. 2021;28:3077-3091 pubmed publisher
Genah S, Cialdai F, Ciccone V, Sereni E, Morbidelli L, Monici M. Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing. Biomedicines. 2021;9: pubmed publisher
Takahashi S, Fukushima H, Yu Z, Tomita H, Kida S. Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory. Brain Behav Immun. 2021;94:79-88 pubmed publisher
Jafari M, Schumacher A, Snaidero N, Ullrich Gavilanes E, Neziraj T, Kocsis Jutka V, et al. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 2021;: pubmed publisher
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed publisher
Sharma N, Akhade A, Ismaeel S, Qadri A. Serum-borne lipids amplify TLR-activated inflammatory responses. J Leukoc Biol. 2021;109:821-831 pubmed publisher
Lee S, Kim S, Kang H, Lim H, Kwon Y, Jo M, et al. The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response. J Neuroinflammation. 2020;17:299 pubmed publisher
Boytard L, Hadi T, Silvestro M, Qu H, Kumpfbeck A, Sleiman R, et al. Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Nat Commun. 2020;11:4311 pubmed publisher
Liu M, Yan M, Lv H, Wang B, Lv X, Zhang H, et al. Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis. Cell Rep. 2020;32:107990 pubmed publisher
Ni M, Zhou H, Zhang J, Jin D, Lu T, Busuttil R, et al. Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury. J Immunol. 2020;205:1147-1156 pubmed publisher
Hanschmann E, Petry S, Eitner S, Maresch C, Lingwal N, Lillig C, et al. Paracrine regulation and improvement of β-cell function by thioredoxin. Redox Biol. 2020;34:101570 pubmed publisher
Uccellini M, Bardina S, Sánchez Aparicio M, White K, Hou Y, Lim J, et al. Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice. Cell Rep. 2020;31:107498 pubmed publisher
Ngo K, Kishimoto K, Davis Turak J, Pimplaskar A, Cheng Z, Spreafico R, et al. Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Rep. 2020;30:2758-2775.e6 pubmed publisher
Ariana A, Alturki N, Hajjar S, Stumpo D, Tiedje C, Alnemri E, et al. Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. J Biol Chem. 2020;295:4661-4672 pubmed publisher
Wheeler M, Clark I, Tjon E, Li Z, Zandee S, Couturier C, et al. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020;578:593-599 pubmed publisher
Simões F, Cahill T, Kenyon A, Gavriouchkina D, Vieira J, Sun X, et al. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair. Nat Commun. 2020;11:600 pubmed publisher
Darling T, Mimche P, Bray C, Umaru B, Brady L, Stone C, et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020;16:e1008261 pubmed publisher
Tran H, Ley R, Gewirtz A, Chassaing B. Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases. Nat Commun. 2019;10:5650 pubmed publisher
Pennig J, Scherrer P, Gissler M, Anto Michel N, Hoppe N, Füner L, et al. Glucose lowering by SGLT2-inhibitor empagliflozin accelerates atherosclerosis regression in hyperglycemic STZ-diabetic mice. Sci Rep. 2019;9:17937 pubmed publisher
Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421 pubmed publisher
Zhang B, Li M, Yin R, Liu Y, Yang Y, Mitchell Richards K, et al. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. JCI Insight. 2019;4: pubmed publisher
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
Chan H, Bhide K, Vaidyam A, Hedrick V, Sobreira T, Sors T, et al. Proteomic Analysis of 3T3-L1 Adipocytes Treated with Insulin and TNF-α. Proteomes. 2019;7: pubmed publisher
Yu J, Zhu H, Taheri S, Mondy W, Bonilha L, Magwood G, et al. Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia. J Neurosci. 2019;39:9465-9476 pubmed publisher
Wong J, Garcia Carbonell R, Zelic M, Ho S, Boland B, Yao S, et al. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
Kumrungsee T, Kariya T, Hashimoto K, Koyano T, Yazawa N, Hashimoto T, et al. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment. Sci Rep. 2019;9:14101 pubmed publisher
Ondee T, Gillen J, Visitchanakun P, Somparn P, Issara Amphorn J, Dang Phi C, et al. Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice. Cells. 2019;8: pubmed publisher
Bensellam M, Chan J, Lee K, Joglekar M, Hardikar A, Loudovaris T, et al. Phlda3 regulates beta cell survival during stress. Sci Rep. 2019;9:12827 pubmed publisher
Chiang H, Chu P, Lee T. MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells. J Biomed Sci. 2019;26:61 pubmed publisher
Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, et al. Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement. J Immunol Res. 2019;2019:9716758 pubmed publisher
Darkwah S, Nago N, Appiah M, Myint P, Kawamoto E, Shimaoka M, et al. Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis. Biomedicines. 2019;7: pubmed publisher
Li J, Ayoub A, Xiu Y, Yin X, Sanders J, Mesfin A, et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat Commun. 2019;10:2795 pubmed publisher
Zhang N, Heruth D, Wu W, Zhang L, Nsumu M, Shortt K, et al. Functional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models. Cell Biosci. 2019;9:40 pubmed publisher
Zhao G, Zhong Y, Su W, Liu S, Song X, Hou T, et al. Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality. Mol Cell Biol. 2019;39: pubmed publisher
Arredouani A, Diane A, Khattab N, Bensmail I, Aoudé I, Chikri M, et al. DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation. Sci Rep. 2019;9:4772 pubmed publisher
Qiu M, Huang K, Liu Y, Yang Y, Tang H, Liu X, et al. Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunol. 2019;: pubmed publisher
Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, et al. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment. Nucleic Acids Res. 2019;47:3365-3382 pubmed publisher
Paduch K, Debus A, Rai B, Schleicher U, Bogdan C. Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1. J Immunol. 2019;202:1453-1464 pubmed publisher
Vendrov A, Sumida A, Canugovi C, Lozhkin A, Hayami T, Madamanchi N, et al. NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Redox Biol. 2019;21:101063 pubmed publisher
Dou F, Chu X, Zhang B, Liang L, Lu G, Ding J, et al. EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway. Mol Brain. 2018;11:75 pubmed publisher
Aguilar Valles A, Haji N, De Gregorio D, Matta Camacho E, Eslamizade M, Popic J, et al. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nat Commun. 2018;9:2459 pubmed publisher
Archer Lahlou E, Lan C, Jagoe R. Physiological culture conditions alter myotube morphology and responses to atrophy treatments: implications for in vitro research on muscle wasting. Physiol Rep. 2018;6:e13726 pubmed publisher
Martins I, Raza S, Voisin L, Dakhli H, Allouch A, Law F, et al. Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death. Cell Death Dis. 2018;9:716 pubmed publisher
Rijal D, Ariana A, Wight A, Kim K, Alturki N, Aamir Z, et al. Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1. J Biol Chem. 2018;293:11913-11927 pubmed publisher
Cramer Z, Sadek J, Vazquez G, Di Marco S, Pause A, Pelletier J, et al. eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways. Sci Rep. 2018;8:8414 pubmed publisher
Hall D, Griss T, Ma J, Sanchez B, Sadek J, Tremblay A, et al. The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting. EMBO Mol Med. 2018;10: pubmed publisher
Alejo A, Ruiz Argüello M, Pontejo S, Fernández de Marco M, Saraiva M, Hernaez B, et al. Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation. Nat Commun. 2018;9:1790 pubmed publisher
Yassin M, Kissow H, Vainer B, Joseph P, Hay Schmidt A, Olsen J, et al. Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice. Sci Rep. 2018;8:6905 pubmed publisher
Drolia R, Tenguria S, Durkes A, Turner J, Bhunia A. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation. Cell Host Microbe. 2018;23:470-484.e7 pubmed publisher
Jeong B. ATF3 mediates the inhibitory action of TNF-α on osteoblast differentiation through the JNK signaling pathway. Biochem Biophys Res Commun. 2018;499:696-701 pubmed publisher
Meyer zu Horste G, Przybylski D, Schramm M, Wang C, Schnell A, Lee Y, et al. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018;48:556-569.e7 pubmed publisher
Kobori T, Hamasaki S, Kitaura A, Yamazaki Y, Nishinaka T, Niwa A, et al. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis. Front Immunol. 2018;9:334 pubmed publisher
da Silva Lima F, da Rocha Romero A, Hastreiter A, Nogueira Pedro A, Makiyama E, Colli C, et al. An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells. J Nutr Biochem. 2018;55:200-208 pubmed publisher
Lin H, Wang J, Wang J, Li W, Wang X, Alston J, et al. GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function. Mol Metab. 2018;11:205-211 pubmed publisher
Kanter J, Kramer F, Barnhart S, Duggan J, Shimizu Albergine M, Kothari V, et al. A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome. Diabetes. 2018;67:946-959 pubmed publisher
Lee C, Zhang H, Singh S, Koo L, Kabat J, Tsang H, et al. C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation. elife. 2018;7: pubmed publisher
Wang Q, Lv S, Guo Y, Duan J, Dong S, Wang Q, et al. Pharmacological Effect of Caulophyllum robustum on Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-κB, and Proinflammatory Cytokines In Vivo and In Vitro. Evid Based Complement Alternat Med. 2017;2017:8134321 pubmed publisher
Sapoznik E, Niu G, Zhou Y, Prim P, Criswell T, Soker S. A real-time monitoring platform of myogenesis regulators using double fluorescent labeling. PLoS ONE. 2018;13:e0192654 pubmed publisher
Klement W, Garbelli R, Zub E, Rossini L, Tassi L, Girard B, et al. Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature. Neurobiol Dis. 2018;113:70-81 pubmed publisher
Liu J, Mustafa S, Barratt D, Hutchinson M. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Front Immunol. 2018;9:3 pubmed publisher
Mancini A, Tantucci M, Mazzocchetti P, de Iure A, Durante V, Macchioni L, et al. Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis. Neurobiol Dis. 2018;113:97-108 pubmed publisher
Barliya T, Dardik R, Nisgav Y, Dachbash M, Gaton D, Kenet G, et al. Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients. Mol Vis. 2017;23:922-932 pubmed
Lin H, Muramatsu R, Maedera N, Tsunematsu H, Hamaguchi M, Koyama Y, et al. Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis. EBioMedicine. 2018;27:71-85 pubmed publisher
Grössinger E, Kang M, Bouchareychas L, Sarin R, Haudenschild D, Borodinsky L, et al. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018;200:749-757 pubmed publisher
Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, et al. H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest. 2018;128:233-247 pubmed publisher
Winther M, Holdfeldt A, Sundqvist M, Rajabkhani Z, Gabl M, Bylund J, et al. Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question. PLoS ONE. 2017;12:e0185132 pubmed publisher
Akbar N, Digby J, Cahill T, Tavare A, Corbin A, Saluja S, et al. Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction. JCI Insight. 2017;2: pubmed publisher
Haim Y, Bluher M, Konrad D, Goldstein N, Kloting N, Harman Boehm I, et al. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. Mol Metab. 2017;6:725-736 pubmed publisher
Marrero L, Simkin J, Sammarco M, Muneoka K. Fibroblast reticular cells engineer a blastema extracellular network during digit tip regeneration in mice. Regeneration (Oxf). 2017;4:69-84 pubmed publisher
Yi C, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, et al. TNFα drives mitochondrial stress in POMC neurons in obesity. Nat Commun. 2017;8:15143 pubmed publisher
Karamita M, Barnum C, Mobius W, TANSEY M, Szymkowski D, Lassmann H, et al. Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia. JCI Insight. 2017;2: pubmed publisher
Chung K, Chatzigeorgiou A, Economopoulou M, Garcia Martin R, Alexaki V, Mitroulis I, et al. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017;18:654-664 pubmed publisher
Sireesh D, Ganesh M, Dhamodharan U, Sakthivadivel M, Sivasubramanian S, Gunasekaran P, et al. Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade. J Nutr Biochem. 2017;44:11-21 pubmed publisher
Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin M. Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Sci Rep. 2017;7:44189 pubmed publisher
Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi M, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol. 2017;140:584-587.e8 pubmed publisher
Huang W, Fan W, Wang Y, Han D, Li X, Li S, et al. Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway. Cell Death Discov. 2017;3:16097 pubmed publisher
Haga H, Yan I, Takahashi K, Matsuda A, Patel T. Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice. Stem Cells Transl Med. 2017;6:1262-1272 pubmed publisher
Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, et al. Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia. EBioMedicine. 2017;16:172-183 pubmed publisher
Lu J, Chiang Y, Lin Y, Chang Y, Lu C, Chen T, et al. Disruption of Lipid Raft Function Increases Expression and Secretion of Monocyte Chemoattractant Protein-1 in 3T3-L1 Adipocytes. PLoS ONE. 2016;11:e0169005 pubmed publisher
da Costa R, Fais R, Dechandt C, Louzada Junior P, Alberici L, Lobato N, et al. Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. Br J Pharmacol. 2017;174:3527-3541 pubmed publisher
Csépányi Kömi R, Wisniewski E, Bartos B, Lévai P, Nemeth T, Balazs B, et al. Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice. J Immunol. 2016;197:2807-15 pubmed publisher
Newton K, Dugger D, Maltzman A, Greve J, Hedehus M, Martin McNulty B, et al. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Cell Death Differ. 2016;23:1565-76 pubmed publisher
Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, et al. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells. Oncogene. 2016;35:5953-5962 pubmed publisher
Pasi S, Kant R, Surolia A. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem. 2016;291:12358-69 pubmed publisher
Liu Z, Zhang N, Shao B, Panicker S, Fu J, McEver R. Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice. J Biol Chem. 2016;291:1441-7 pubmed publisher
Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, et al. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol. 2015;195:4415-25 pubmed publisher
Gómez D, Diehl M, Crosby E, Weinkopff T, Debes G. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation. J Immunol. 2015;195:3531-6 pubmed publisher
Goodall L, Ovecka M, Rycroft D, Friel S, Sanderson A, Mistry P, et al. Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension. PLoS ONE. 2015;10:e0137065 pubmed publisher
Carlson N, Bellamkonda S, Schmidt L, Redd J, Huecksteadt T, Weber L, et al. The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death. J Neuroinflammation. 2015;12:101 pubmed publisher
Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell R, Spilianakis C. Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression. Proc Natl Acad Sci U S A. 2015;112:E1577-86 pubmed publisher
Babu D, Leclercq G, Goossens V, Vanden Berghe T, Van Hamme E, Vandenabeele P, et al. Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells. Cell Signal. 2015;27:1141-58 pubmed publisher
Hennigar S, Seo Y, Sharma S, Soybel D, Kelleher S. ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution. Sci Rep. 2015;5:8033 pubmed publisher
Sun C, Schattgen S, Pisitkun P, Jorgensen J, Hilterbrand A, Wang L, et al. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. J Immunol. 2015;194:1819-31 pubmed publisher
Rožman S, Yousefi S, Oberson K, Kaufmann T, Benarafa C, Simon H. The generation of neutrophils in the bone marrow is controlled by autophagy. Cell Death Differ. 2015;22:445-56 pubmed publisher
Li L, Chen Y, Doan J, Murray J, Molkentin J, Liu Q. Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation. 2014;130:2162-72 pubmed publisher
Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, et al. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. elife. 2014;3:e02809 pubmed publisher
Bone R, Gai Y, Magrioti V, Kokotou M, Ali T, Lei X, et al. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes. 2015;64:541-54 pubmed publisher
Kowalewska P, Patrick A, Fox Robichaud A. Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. PLoS ONE. 2014;9:e104537 pubmed publisher
Dahllöf M, Christensen D, Harving M, Wagner B, Mandrup Poulsen T, Lundh M. HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interferon Cytokine Res. 2015;35:63-70 pubmed publisher
McComb S, Cessford E, Alturki N, Joseph J, Shutinoski B, Startek J, et al. Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proc Natl Acad Sci U S A. 2014;111:E3206-13 pubmed publisher
Krautbauer S, Eisinger K, Hader Y, Buechler C. Free fatty acids and IL-6 induce adipocyte galectin-3 which is increased in white and brown adipose tissues of obese mice. Cytokine. 2014;69:263-71 pubmed publisher
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, et al. PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat Commun. 2014;5:4436 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T. Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2?. J Immunol. 2014;193:1459-67 pubmed publisher
Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, et al. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine. 2014;68:101-9 pubmed publisher
Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, et al. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gin. J Biol Chem. 2014;289:15621-30 pubmed publisher
Noubade R, Wong K, Ota N, Rutz S, Eidenschenk C, Valdez P, et al. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature. 2014;509:235-9 pubmed publisher
Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, et al. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney Int. 2014;86:358-69 pubmed publisher
Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, et al. Toxoplasma gondii virulence factor ROP18 inhibits the host NF-?B pathway by promoting p65 degradation. J Biol Chem. 2014;289:12578-92 pubmed publisher
Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol. 2014;192:3618-25 pubmed publisher
Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, et al. IFN-? or IFN-? ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. J Immunol. 2014;192:3793-804 pubmed publisher
Ramkhelawon B, Hennessy E, Ménager M, Ray T, Sheedy F, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014;20:377-84 pubmed publisher
Newton K, Hildebrand J, Shen Z, Rodriguez D, Alvarez Diaz S, Petersen S, et al. Is SIRT2 required for necroptosis?. Nature. 2014;506:E4-6 pubmed publisher
Suresh Babu S, Valdez Y, Xu A, O Byrne A, Calvo F, Lei V, et al. TGF?-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 2014;14:113 pubmed publisher
Gonzalvo Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, et al. Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol. 2014;192:2366-73 pubmed publisher
McMichael B, Scherer K, Franklin N, Lee B. The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity. PLoS ONE. 2014;9:e87402 pubmed publisher
Weckbach L, Gola A, Winkelmann M, Jakob S, Groesser L, Borgolte J, et al. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ?2 integrins (CD11/CD18). Blood. 2014;123:1887-96 pubmed publisher
González Y, Doens D, Santamaría R, Ramos M, Restrepo C, Barros de Arruda L, et al. A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages. PLoS ONE. 2013;8:e84107 pubmed publisher
Lindblom R, Ström M, Heinig M, Al Nimer F, Aeinehband S, Berg A, et al. Unbiased expression mapping identifies a link between the complement and cholinergic systems in the rat central nervous system. J Immunol. 2014;192:1138-53 pubmed publisher
Temme S, Jacoby C, Ding Z, Bönner F, Borg N, Schrader J, et al. Technical advance: monitoring the trafficking of neutrophil granulocytes and monocytes during the course of tissue inflammation by noninvasive 19F MRI. J Leukoc Biol. 2014;95:689-97 pubmed publisher
Xu C, Yu P, Han X, Du L, Gan J, Wang Y, et al. TGF-? promotes immune responses in the presence of mesenchymal stem cells. J Immunol. 2014;192:103-9 pubmed publisher
Munitic I, Giardino Torchia M, Meena N, Zhu G, Li C, Ashwell J. Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells. J Immunol. 2013;191:6231-40 pubmed publisher
Moon C, VanDussen K, Miyoshi H, Stappenbeck T. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol. 2014;7:818-28 pubmed publisher
Leslie K, Song G, Barrick S, Wehbi V, Vilardaga J, Bauer P, et al. Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-?B (NF-?B): a feed-forward loop for systemic and vascular inflammation. J Biol Chem. 2013;288:36426-36 pubmed publisher
Holzscheiter M, Layland L, Loffredo Verde E, Mair K, Vogelmann R, Langer R, et al. Lack of host gut microbiota alters immune responses and intestinal granuloma formation during schistosomiasis. Clin Exp Immunol. 2014;175:246-57 pubmed publisher
Kook S, Zhan X, Cleghorn W, Benovic J, Gurevich V, Gurevich E. Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death. Cell Death Differ. 2014;21:172-84 pubmed publisher
Xu C, Chang A, Hack B, Eadon M, Alper S, Cunningham P. TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int. 2014;85:72-81 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Sato T, Kotake D, Hiratsuka M, Hirasawa N. Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. PLoS ONE. 2013;8:e59702 pubmed publisher
Yoshimura T, Howard O, Ito T, Kuwabara M, Matsukawa A, Chen K, et al. Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells. PLoS ONE. 2013;8:e58791 pubmed publisher
Do Umehara H, Chen C, Urich D, Zhou L, Qiu J, Jang S, et al. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-?. Nat Immunol. 2013;14:461-9 pubmed publisher
Dearth C, Goh Q, Marino J, Cicinelli P, Torres Palsa M, Pierre P, et al. Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. PLoS ONE. 2013;8:e58486 pubmed publisher
Jayaraman P, Sada Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, et al. IL-1? promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013;190:4196-204 pubmed publisher
Bocian C, Urbanowitz A, Owens R, Iozzo R, Götte M, Seidler D. Decorin potentiates interferon-? activity in a model of allergic inflammation. J Biol Chem. 2013;288:12699-711 pubmed publisher
Sandig H, Jobbings C, Roldan N, Whittingham Dowd J, Orinska Z, Takeuchi O, et al. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol. 2013;43:979-88 pubmed publisher
Shrestha N, Bahnan W, Wiley D, Barber G, Fields K, Schesser K. Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. J Biol Chem. 2012;287:28738-44 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Proebstl D, Voisin M, Woodfin A, Whiteford J, D Acquisto F, Jones G, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med. 2012;209:1219-34 pubmed publisher
Bradley L, Douglass M, Chatterjee D, Akira S, Baaten B. Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. PLoS Pathog. 2012;8:e1002641 pubmed publisher
Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, et al. Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1? regulation of FXR expression. Mol Endocrinol. 2012;26:775-85 pubmed publisher
Quinton L, Blahna M, Jones M, Allen E, Ferrari J, Hilliard K, et al. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012;122:1758-63 pubmed publisher
Chuquimia O, Petursdottir D, Rahman M, Hartl K, Singh M, Fernandez C. The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE. 2012;7:e32125 pubmed publisher
Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu D, Yanaba M, et al. Host-derived MCP-1 and MIP-1? regulate protective anti-tumor immunity to localized and metastatic B16 melanoma. Am J Pathol. 2012;180:365-74 pubmed publisher
Taube C, Tertilt C, Gyülveszi G, Dehzad N, Kreymborg K, Schneeweiss K, et al. IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease. PLoS ONE. 2011;6:e21799 pubmed publisher
El Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011;12:568-75 pubmed publisher
Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, et al. IL-17A and TNF-? exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011;186:3197-205 pubmed publisher
Bruggeman L, Drawz P, Kahoud N, Lin K, Barisoni L, Nelson P. TNFR2 interposes the proliferative and NF-?B-mediated inflammatory response by podocytes to TNF-?. Lab Invest. 2011;91:413-25 pubmed publisher
Petri B, Kaur J, Long E, Li H, Parsons S, Butz S, et al. Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo. Blood. 2011;117:942-52 pubmed publisher
Le Gall S, Maretzky T, Issuree P, Niu X, Reiss K, Saftig P, et al. ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. J Cell Sci. 2010;123:3913-22 pubmed publisher
Bhatnagar S, Panguluri S, Gupta S, Dahiya S, Lundy R, Kumar A. Tumor necrosis factor-? regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells. PLoS ONE. 2010;5:e13262 pubmed publisher
Blumberg H, Dinh H, Dean C, Trueblood E, Bailey K, Shows D, et al. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J Immunol. 2010;185:4354-62 pubmed publisher
Kwon H, Won Y, Suh H, Jeon J, Shao Y, Yoon S, et al. Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis. J Immunol. 2010;185:3980-9 pubmed publisher
Chou R, Kim N, Sadik C, Seung E, Lan Y, Byrne M, et al. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity. 2010;33:266-78 pubmed publisher
Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace W, et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010;33:71-83 pubmed publisher
Murthy A, Defamie V, Smookler D, Di Grappa M, Horiuchi K, Federici M, et al. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest. 2010;120:2731-44 pubmed publisher
Tiller G, Laumen H, Fischer Posovszky P, Finck A, Skurk T, Keuper M, et al. LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism. Int J Obes (Lond). 2011;35:208-16 pubmed publisher
Bixel M, Li H, Petri B, Khandoga A, Khandoga A, Zarbock A, et al. CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood. 2010;116:1172-84 pubmed publisher
Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic I, Socher I, et al. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood. 2010;116:841-9 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, et al. Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood. 2010;115:3118-27 pubmed publisher
Lebrun Julien F, Bertrand M, De Backer O, Stellwagen D, Morales C, Di Polo A, et al. ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A. 2010;107:3817-22 pubmed publisher
Blanchet M, Gold M, Maltby S, Bennett J, Petri B, Kubes P, et al. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol. 2010;184:1292-9 pubmed publisher
Lee E, Rosenbaum J, Planck S. Epifluorescence intravital microscopy of murine corneal dendritic cells. Invest Ophthalmol Vis Sci. 2010;51:2101-8 pubmed publisher
Chen X, Fang L, Song S, Guo T, Liu A, Zhang J. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J Immunol. 2009;183:6135-44 pubmed publisher
Kotarsky K, Sitnik K, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, et al. A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. Mucosal Immunol. 2010;3:40-8 pubmed publisher
Haybaeck J, Zeller N, Wolf M, Weber A, Wagner U, Kurrer M, et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009;16:295-308 pubmed publisher
Wahl E, Aronson J, Liu L, Skinner R, Miller M, Cockrell G, et al. Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice. Bone. 2010;46:410-7 pubmed publisher
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170-8 pubmed publisher
Page K, Ledford J, Zhou P, Wills Karp M. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice. J Immunol. 2009;183:3400-8 pubmed publisher
Raedler H, Yang M, Lalli P, Medof M, Heeger P. Primed CD8(+) T-cell responses to allogeneic endothelial cells are controlled by local complement activation. Am J Transplant. 2009;9:1784-95 pubmed publisher
Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, et al. Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing. J Bone Miner Res. 2009;24:2056-65 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Hidalgo A, Chang J, Jang J, Peired A, Chiang E, Frenette P. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med. 2009;15:384-91 pubmed publisher
Wieland C, van der Windt G, Florquin S, McKenzie A, van der Poll T. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 2009;11:524-30 pubmed publisher
Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, et al. Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med. 2009;15:300-5 pubmed publisher
Das M, Sabio G, Jiang F, Rincon M, Flavell R, Davis R. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 2009;136:249-60 pubmed publisher
Dienz O, Eaton S, Bond J, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009;206:69-78 pubmed publisher
Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, et al. A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum. 2008;58:3510-9 pubmed publisher
Audoy Rémus J, Richard J, Soulet D, Zhou H, Kubes P, Vallières L. Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci. 2008;28:10187-99 pubmed publisher
Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, et al. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. J Invest Dermatol. 2009;129:650-6 pubmed publisher
Shigeta A, Matsumoto M, Tedder T, Lowe J, Miyasaka M, Hirata T. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood. 2008;112:4915-23 pubmed publisher
Zarbock A, Abram C, Hundt M, Altman A, Lowell C, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008;205:2339-47 pubmed publisher
Mahoney D, Cheung H, Mrad R, Plenchette S, Simard C, Enwere E, et al. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A. 2008;105:11778-83 pubmed publisher
Resch U, Schichl Y, Sattler S, de Martin R. XIAP regulates intracellular ROS by enhancing antioxidant gene expression. Biochem Biophys Res Commun. 2008;375:156-61 pubmed publisher
Yakubenia S, Frommhold D, Schölch D, Hellbusch C, Korner C, Petri B, et al. Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc. Blood. 2008;112:1472-81 pubmed publisher
Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, et al. Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. Exp Hematol. 2008;36:545-558 pubmed publisher
Ashare A, Nymon A, Doerschug K, Morrison J, Monick M, Hunninghake G. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am J Respir Crit Care Med. 2008;178:149-57 pubmed publisher
Kerfoot S, Andonegui G, Bonder C, Liu L. Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo. Am J Physiol Heart Circ Physiol. 2008;294:H2524-34 pubmed publisher
Norman M, Zbytnuik L, Kubes P. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism. Eur J Immunol. 2008;38:1368-80 pubmed publisher
Zhang Z, Kim S, Varghese T, Thomas G, Hummel M, Abecassis M. TNF receptor independent activation of the cytomegalovirus major immediate early enhancer in response to transplantation. Transplantation. 2008;85:1039-45 pubmed publisher
Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr D, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol. 2008;22:1416-26 pubmed publisher
von zur Muhlen C, Sibson N, Peter K, Campbell S, Wilainam P, Grau G, et al. A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. J Clin Invest. 2008;118:1198-207 pubmed publisher
Narita M, Shimamura M, Imai S, Kubota C, Yajima Y, Takagi T, et al. Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice. Neuroscience. 2008;152:477-86 pubmed publisher
Tjwa M, Bellido Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, et al. Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood. 2008;111:4096-105 pubmed
Shojaei F, Wu X, ZHONG C, Yu L, Liang X, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450:825-31 pubmed
Kaminski A, Ma N, Donndorf P, Lindenblatt N, Feldmeier G, Ong L, et al. Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells. Lab Invest. 2008;88:58-69 pubmed
Antonopoulos C, Cumberbatch M, Mee J, Dearman R, Wei X, Liew F, et al. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol. 2008;83:361-7 pubmed
Zetterström C, Jiang W, Wähämaa H, Ostberg T, Aveberger A, Schierbeck H, et al. Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. J Leukoc Biol. 2008;83:31-8 pubmed
Zalevsky J, Secher T, Ezhevsky S, Janot L, Steed P, O BRIEN C, et al. Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol. 2007;179:1872-83 pubmed
Liu L, Puri K, Penninger J, Kubes P. Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 2007;110:1191-8 pubmed
Weiser S, Miu J, Ball H, Hunt N. Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine. 2007;37:84-91 pubmed
Dogra C, Changotra H, Wedhas N, Qin X, Wergedal J, Kumar A. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J. 2007;21:1857-69 pubmed
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky M, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007;13:156-63 pubmed
Robertson S, Care A, Skinner R. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod. 2007;76:738-48 pubmed
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, et al. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J Immunol. 2006;177:8650-7 pubmed
Penido C, Conte F, Chagas M, Rodrigues C, Pereira J, Henriques M. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm Res. 2006;55:457-64 pubmed
Johnson L, Clasper S, Holt A, Lalor P, Baban D, Jackson D. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203:2763-77 pubmed
Higgins S, Jarnicki A, Lavelle E, Mills K. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J Immunol. 2006;177:7980-9 pubmed
Sugaya M, Fang L, Cardones A, Kakinuma T, Jaber S, Blauvelt A, et al. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J Immunol. 2006;177:7665-72 pubmed
Nahrendorf M, Jaffer F, Kelly K, Sosnovik D, Aikawa E, Libby P, et al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006;114:1504-11 pubmed
Nakamichi K, Saiki M, Kitani H, Kuboyama Y, Morimoto K, Takayama Ito M, et al. Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia. Neurosci Lett. 2006;407:205-10 pubmed
Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, et al. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther. 2006;8:R146 pubmed
Baleeiro C, Christensen P, Morris S, Mendez M, Wilcoxen S, Paine R. GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1246-55 pubmed
Butovsky O, Koronyo Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A. 2006;103:11784-9 pubmed
Ramos C, Fernandes K, Canetti C, Teixeira M, Silva J, Cunha F. Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur J Immunol. 2006;36:2025-34 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
An H, Jeong H, Um J, Kim H, Hong S. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol. 2006;106:418-24 pubmed
Mendez M, Morris S, Wilcoxen S, Greeson E, Moore B, Paine R. Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006;290:L962-70 pubmed
Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar A, Pluchino S, et al. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006;31:149-60 pubmed
Costa S, Yshii L, Poston R, Muscara M, Brain S. Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature. J Neuroimmunol. 2006;171:99-109 pubmed
Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115:2180-6 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Ellaban E, Bolgos G, Remick D. Selective macrophage suppression during sepsis. Cell Immunol. 2004;231:103-11 pubmed
Mbebi C, Gonzalez de Aguilar J, See V, Dupuis L, Frossard N, Mercken L, et al. Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons. Neurobiol Dis. 2005;19:129-41 pubmed
Wei S, Kitaura H, Zhou P, Ross F, Teitelbaum S. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115:282-90 pubmed
Ching S, He L, Lai W, Quan N. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun. 2005;19:127-37 pubmed
Piggott D, Eisenbarth S, Xu L, Constant S, Huleatt J, Herrick C, et al. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J Clin Invest. 2005;115:459-67 pubmed
Simon C, Seckert C, Dreis D, Reddehase M, Grzimek N. Role for tumor necrosis factor alpha in murine cytomegalovirus transcriptional reactivation in latently infected lungs. J Virol. 2005;79:326-40 pubmed
Matzen K, Dirkx A, oude Egbrink M, Speth C, Gotte M, Ascherl G, et al. HIV-1 Tat increases the adhesion of monocytes and T-cells to the endothelium in vitro and in vivo: implications for AIDS-associated vasculopathy. Virus Res. 2004;104:145-55 pubmed
Bleier J, Pillarisetty V, Shah A, Dematteo R. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J Immunol. 2004;172:7408-16 pubmed
LaBue M, Colburn K, Green L. Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity. Thyroid. 2004;14:249-62 pubmed
Miller M, Hejazi A, Wei S, Cahalan M, Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A. 2004;101:998-1003 pubmed
Dunne J, Collins R, Beaudet A, Ballantyne C, Ley K. Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation. J Immunol. 2003;171:6105-11 pubmed
Hong S, Gronert K, Devchand P, Moussignac R, Serhan C. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem. 2003;278:14677-87 pubmed
De S, Devadas K, Notkins A. Elevated levels of tumor necrosis factor alpha (TNF-alpha) in human immunodeficiency virus type 1-transgenic mice: prevention of death by antibody to TNF-alpha. J Virol. 2002;76:11710-4 pubmed
Coope H, Atkinson P, Huhse B, Belich M, Janzen J, Holman M, et al. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J. 2002;21:5375-85 pubmed
Miller G, Pillarisetty V, Shah A, Lahrs S, Xing Z, Dematteo R. Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function. J Immunol. 2002;169:2875-85 pubmed
Chaisson M, Brooling J, Ladiges W, Tsai S, Fausto N. Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest. 2002;110:193-202 pubmed
Blumenthal R, Reising A, Leon E, Goldenberg D. Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines. Clin Cancer Res. 2002;8:1301-9 pubmed
Medvedev A, Kopydlowski K, Vogel S. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol. 2000;164:5564-74 pubmed
image
image 1 :
R&D Systems 410-MT-010 image 1
Graph showing dose-dependent bioactivity of mouse TNF-alpha protein
product information
brand :
R&D Systems
master code :
410-MT
SKU :
410-MT-010
product name :
Recombinant Mouse TNF-alpha (aa 80-235) Protein
unit size :
10 ug
description :
The Recombinant Mouse TNF-alpha (aa 80-235) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse TNF-alpha (aa 80-235) Protein, CF has been validated for the following applications: Bioactivity.
target :
TNF-alpha
category :
Proteins and Enzymes
alt names :
APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
17 kDa
gene symbol :
Tnf
details of functionality :
Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 8-50 pg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P06804
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse TNF-alpha (aa 80-235) Protein
USD :
209
Jul-22 :
226 USD
sizes available :
10 ug (also 25 ug, 50 ug, 100 ug, 1000 ug)
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.