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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-7 Protein
catalog :
407-ML-005
quantity :
5 ug (also 25 ug, 200 ug)
price :
259 USD
more info or order :
citations: 94
Reference
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Oyesola O, Duque C, Huang L, Larson E, Früh S, Webb L, et al. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung. J Immunol. 2020;204:1001-1011 pubmed publisher
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Martin S, Fitter S, El Khawanky N, Grose R, Walkley C, Purton L, et al. mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Sci Rep. 2018;8:14501 pubmed publisher
Ricardo Gonzalez R, Van Dyken S, Schneider C, Lee J, Nussbaum J, Liang H, et al. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018;19:1093-1099 pubmed publisher
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Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul S, et al. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018;30:141-154 pubmed publisher
Seki A, Rutz S. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells. J Exp Med. 2018;215:985-997 pubmed publisher
Yamaguchi M, Samuchiwal S, Quehenberger O, Boyce J, Balestrieri B. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. Mucosal Immunol. 2018;11:615-626 pubmed publisher
Dai K, Huang Y, Chen Z, Sun X, Yang L, Jiang Y. Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model. Eur J Immunol. 2018;48:683-695 pubmed publisher
Lee Sayer S, Maeshima N, Dougan M, Dahiya A, Arif A, Dosanjh M, et al. Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells. Eur J Immunol. 2018;48:803-814 pubmed publisher
Tong P, Granato A, Zuo T, Chaudhary N, Zuiani A, Han S, et al. IgH isotype-specific B cell receptor expression influences B cell fate. Proc Natl Acad Sci U S A. 2017;114:E8411-E8420 pubmed publisher
Wallrapp A, Riesenfeld S, Burkett P, Abdulnour R, Nyman J, Dionne D, et al. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017;549:351-356 pubmed publisher
Han M, Rajput C, Hong J, Lei J, Hinde J, Wu Q, et al. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. J Immunol. 2017;199:1308-1318 pubmed publisher
Rodríguez Hernández G, Hauer J, Martín Lorenzo A, Schäfer D, Bartenhagen C, García Ramírez I, et al. Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases. Cancer Res. 2017;77:4365-4377 pubmed publisher
Moffett H, Cartwright A, Kim H, Godec J, Pyrdol J, Aijö T, et al. The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017;18:791-799 pubmed publisher
Shukla S, Langley M, Singh J, Edgar J, Mohtashami M, Zuniga Pflucker J, et al. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods. 2017;14:531-538 pubmed publisher
de Bruijn M, Rip J, van der Ploeg E, van Greuningen L, Ta V, Kil L, et al. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling. J Immunol. 2017;198:3058-3068 pubmed publisher
Itoh Nakadai A, Matsumoto M, Kato H, Sasaki J, Uehara Y, Sato Y, et al. A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors. Cell Rep. 2017;18:2401-2414 pubmed publisher
von Moltke J, O Leary C, Barrett N, Kanaoka Y, Austen K, Locksley R. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017;214:27-37 pubmed publisher
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Zhao L, Frock R, Du Z, Hu J, Chen L, Krangel M, et al. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med. 2016;213:1921-36 pubmed publisher
Sande O, Karim A, Li Q, Ding X, Harding C, Rojas R, et al. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL. J Immunol. 2016;196:691-702 pubmed publisher
Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
Lubeck B, Lapinski P, Oliver J, Ksionda O, Parada L, Zhu Y, et al. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol. 2015;195:31-5 pubmed publisher
Hao B, Naik A, Watanabe A, Tanaka H, Chen L, Richards H, et al. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J Exp Med. 2015;212:809-24 pubmed publisher
Gandhapudi S, Tan C, Marino J, Taylor A, Pack C, Gaikwad J, et al. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015;194:3820-8 pubmed publisher
Gerby B, Tremblay C, Tremblay M, Rojas Sutterlin S, Herblot S, Hébert J, et al. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet. 2014;10:e1004768 pubmed publisher
Bando J, Liang H, Locksley R. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol. 2015;16:153-60 pubmed publisher
Marcais A, Cherfils Vicini J, Viant C, Degouve S, Viel S, Fenis A, et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol. 2014;15:749-757 pubmed publisher
Smeets M, DeLuca E, Wall M, Quach J, Chalk A, Deans A, et al. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. J Clin Invest. 2014;124:3551-65 pubmed publisher
Liu C, Wang H, Yu S, Jin R, Tang H, Liu Y, et al. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol. 2014;193:663-672 pubmed publisher
Green M, Vicente Dueñas C, Romero Camarero I, Long Liu C, Dai B, González Herrero I, et al. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nat Commun. 2014;5:3904 pubmed publisher
Cecil D, Holt G, Park K, Gad E, Rastetter L, Childs J, et al. Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity. Cancer Res. 2014;74:2710-8 pubmed publisher
Wallington Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res. 2014;74:2803-15 pubmed publisher
Cheadle E, Sheard V, Rothwell D, Bridgeman J, Ashton G, Hanson V, et al. Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model. J Immunol. 2014;192:3654-65 pubmed publisher
Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, et al. Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. PLoS ONE. 2014;9:e89649 pubmed publisher
Constantinides M, McDonald B, Verhoef P, Bendelac A. A committed precursor to innate lymphoid cells. Nature. 2014;508:397-401 pubmed publisher
Coffey F, Lee S, Buus T, Lauritsen J, Wong G, Joachims M, et al. The TCR ligand-inducible expression of CD73 marks ?? lineage commitment and a metastable intermediate in effector specification. J Exp Med. 2014;211:329-43 pubmed publisher
Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, et al. Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE. 2013;8:e82590 pubmed publisher
Nacionales D, Gentile L, Vanzant E, Lopez M, Cuenca A, Cuenca A, et al. Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol. 2014;192:612-22 pubmed publisher
Bekiaris V, Sedy J, Macauley M, Rhode Kurnow A, Ware C. The inhibitory receptor BTLA controls ?? T cell homeostasis and inflammatory responses. Immunity. 2013;39:1082-1094 pubmed publisher
Berezhnoy A, Castro I, Levay A, Malek T, Gilboa E. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest. 2014;124:188-97 pubmed
Olive V, SABIO E, Bennett M, De Jong C, Biton A, McGann J, et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. elife. 2013;2:e00822 pubmed publisher
Badano M, Camicia G, Lombardi G, Maglioco A, Cabrera G, Costa H, et al. B-cell lymphopoiesis is regulated by cathepsin L. PLoS ONE. 2013;8:e61347 pubmed publisher
Venigalla R, McGuire V, Clarke R, Patterson Kane J, Najafov A, Toth R, et al. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J. 2013;32:1008-22 pubmed publisher
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol. 2013;190:3153-62 pubmed publisher
Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A. Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase. J Immunol. 2013;190:97-105 pubmed publisher
Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci U S A. 2012;109:17549-54 pubmed publisher
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Bartemes K, Iijima K, Kobayashi T, Kephart G, McKenzie A, Kita H. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol. 2012;188:1503-13 pubmed publisher
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Chen X, Fang L, Song S, Guo T, Liu A, Zhang J. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J Immunol. 2009;183:6135-44 pubmed publisher
WU J, Purton L, Rodda S, Chen M, Weinstein L, McMahon A, et al. Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008;105:16976-81 pubmed publisher
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Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, et al. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007;109:3706-12 pubmed
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Lai L, Zeff R, Goldschneider I. A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells. Blood. 2006;107:1776-84 pubmed
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image
image 1 :
R&D Systems 407-ML-005 image 1
Recombinant Mouse IL-7 Protein Bioactivity
product information
brand :
R&D Systems
master code :
407-ML
SKU :
407-ML-005
product name :
Recombinant Mouse IL-7 Protein
description :
The Recombinant Mouse IL-7 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-7 Protein has been validated for the following applications: Bioactivity.
target :
IL-7
category :
Proteins and Enzymes
sizes available :
5 ug (also 25 ug, 200 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
15 kDa
gene symbol :
Il7
details of functionality :
Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al . (1986) Proc. Natl. Acad. Sci. USA 83 :5894. The ED50 for this effect is 0.15-0.3 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q544C8
applications :
Bioactivity
extended description :
Earn double rewards for reviews
source :
E. coli-derived Recombinant Mouse IL-7 Protein
USD :
259
USD 2023 :
259 USD
product details :
Earn double rewards for reviews
alt names :
IL7, IL-7interleukin-7, interleukin 7, Lymphopoietin-1, PBGF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.