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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-5 Protein
catalog :
405-ML-005
quantity :
5 ug (also 25 ug)
price :
370 USD
more info or order :
citations: 49
Reference
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Ng A, Coughlan H, Hediyeh Zadeh S, Behrens K, Johanson T, Low M, et al. An Erg-driven transcriptional program controls B cell lymphopoiesis. Nat Commun. 2020;11:3013 pubmed publisher
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Calcinotto A, Brevi A, Chesi M, Ferrarese R, Garcia Perez L, Grioni M, et al. Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression. Nat Commun. 2018;9:4832 pubmed publisher
Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D. Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2. Eur J Immunol. 2018;48:1786-1795 pubmed publisher
Trezise S, Karnowski A, Fedele P, Mithraprabhu S, Liao Y, D Costa K, et al. Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Int J Mol Sci. 2018;19: pubmed publisher
Barwick B, Scharer C, Martinez R, Price M, Wein A, Haines R, et al. B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nat Commun. 2018;9:1900 pubmed publisher
Zhu C, Xia L, Li F, Zhou L, Weng Q, Li Z, et al. mTOR complexes differentially orchestrates eosinophil development in allergy. Sci Rep. 2018;8:6883 pubmed publisher
Scharer C, Barwick B, Guo M, Bally A, Boss J. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9:1698 pubmed publisher
Kasagi Y, Chandramouleeswaran P, Whelan K, Tanaka K, Giroux V, Sharma M, et al. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol. 2018;5:333-352 pubmed publisher
Bolus W, Peterson K, Hübler M, KENNEDY A, Gruen M, Hasty A. Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab. 2018;8:86-95 pubmed publisher
Burbage M, Keppler S, Montaner B, Mattila P, Batista F. The Small Rho GTPase TC10 Modulates B Cell Immune Responses. J Immunol. 2017;199:1682-1695 pubmed publisher
Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, et al. IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. PLoS Med. 2017;14:e1002365 pubmed publisher
Dawicki W, Li C, Town J, Zhang X, Gordon J. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3+CD49b-Foxp3- regulatory T cells. J Allergy Clin Immunol. 2017;139:1608-1620.e3 pubmed publisher
Zan H, Tat C, Qiu Z, Taylor J, Guerrero J, Shen T, et al. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun. 2017;8:14244 pubmed publisher
Xia L, Hua W, Jin Y, Tian B, Qiu Z, Zhang C, et al. Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. Cell Death Dis. 2016;7:e2175 pubmed publisher
Schwartz C, Willebrand R, Huber S, Rupec R, WU D, Locksley R, et al. Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis. Blood. 2015;125:3896-904 pubmed publisher
Mantani P, Dunér P, Bengtsson E, Alm R, Ljungcrantz I, Söderberg I, et al. IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice. PLoS ONE. 2015;10:e0117255 pubmed publisher
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Gaudette B, Iwakoshi N, Boise L. Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation. J Biol Chem. 2014;289:23629-40 pubmed publisher
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Shen H, O Byrne P, Ellis R, Wattie J, Tang C, Inman M. The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice. Am J Respir Crit Care Med. 2002;166:146-53 pubmed
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product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
405-ML
SKU :
405-ML-005
product name :
Recombinant Mouse IL-5 Protein
Description :
The Recombinant Mouse IL-5 Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse IL-5 Protein has been validated for the following applications: Bioactivity.
target :
IL-5
category :
Proteins and Enzymes
unit size :
5 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
12-20 kDa, reducing conditions
theoretical molecular weight :
13.1 kDa (monomer)
gene symbol :
Il5
details of functionality :
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.04-0.15 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P04401
applications :
Bioactivity
source :
Sf 21 (baculovirus)-derived Recombinant Mouse IL-5 Protein
USD :
370 USD
alt names :
BCDF mu, B-cell differentiation factor I, BCGFII, EDF, Eo-CSF, Eosinophil differentiation factor, IL5, IL-5T-cell replacing factor, interleukin 5 (colony-stimulating factor, eosinophil), interleukin-5, TRF, TRFB cell differentiation factor I
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.