product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Integrin alpha M beta 2 Protein, CF
catalog :
4047-AM-050
quantity :
50 ug
price :
573 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Lenza M, Egia Mendikute L, Anto xf1 ana Vildosola A, Soares C, Coelho H, Corzana F, et al. Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun. 2023;14:3496 pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A, et al. Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J Biol Chem. 2011;286:7070-81 pubmed publisher
Rao N, Argyle B, Xu X, Reynolds P, Walenga J, Prechel M, et al. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol. 2010;299:C97-110 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
4047-AM
SKU :
4047-AM-050
product name :
Recombinant Human Integrin alpha M beta 2 Protein, CF
description :
The Recombinant Human Integrin alpha M beta 2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha M beta 2 Protein, CF has been validated for the following applications: Bioactivity.
target :
Integrin alpha M beta 2
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and MgCl2.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
165 kDa and 100 kDa, reducing conditions
theoretical molecular weight :
124.7 kDa (Integrin alpha M), 79 kDa (Integrin ß2)
gene symbol :
ITGAM
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of CHO Chinese hamster ovary cells transfected with ICAM-1. The ED50 for this effect is 0.25-1.5 µg/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_001139280 (Integrin alpha M) P05107 (Integrin ß2)
applications :
Bioactivity
product keywords :
4047-AM, rhIntegin aMb2, hIntegin aMb2, carrier-free, carrier free, 4O47-AM, 4047AM, Integrin M 2, Integrin M 2, Integrin alfa M beta 2, Integrin aMss2, Integrin aM, Integrin-aM, ITGAMB2, Integrin aMb2, Integrin alphaMbeta2, Integrin-aMb2, IntegrinalphaM, Integrin aM, Integrin-aM, CD11b, ITGAM, Integrinbeta2, Integrin
source :
CHO-derived Recombinant Human Integrin alpha M beta 2 Protein, CF
USD :
561
USD 2025 :
573 USD
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.