product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein, CF
catalog :
4015-AB-050
quantity :
50 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Harris B, Schreiter J, Chevrier M, Jordan J, Walter M. Human interferon-ϵ and interferon-κ exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R. J Biol Chem. 2018;293:16057-16068 pubmed publisher
Soonthornvacharin S, Rodriguez Frandsen A, Zhou Y, Galvez F, Huffmaster N, Tripathi S, et al. Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbiol. 2017;2:17022 pubmed publisher
Li M, Rao C, Pei D, Wang L, Li Y, Gao K, et al. Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-?, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014;14:8 pubmed publisher
image
image 1 :
R&D Systems 4015-AB-050 image 1
Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
4015-AB
SKU :
4015-AB-050
product name :
Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein, CF
Description :
The Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IFN-alpha/beta R2
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
71-76 kDa, reducing conditions
theoretical molecular weight :
51.3 kDa (monomer)
gene symbol :
IFNAR2
details of functionality :
Measured by its ability to inhibit Type-I IFN-mediated anti-viral activity. The ED50 for this effect, as measured by inhibition of Recombinant Human IFN-beta (Catalog # 8499-IF), is 0.1-0.6 µg/mL
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P48551
applications :
Bioactivity
source :
NS0-derived Recombinant Human IFN-alpha/beta R2 Fc Chimera Protein
USD :
423 USD
alt names :
beta receptor10, human interferon alpha, human interferon alpha/beta receptor, IFNABR, IFN-alpha binding protein, IFN-alpha/beta receptor 2, IFN-alpha-REC, IFN-aR2, IFNAR2, IFNARB, IFNbR2, IFN-bR2, IFN-R, IFN-R-2, interferon (alpha, beta and omega) receptor 2, Interferon alpha binding protein, interferon alpha/beta receptor 2, interferon-alpha/beta receptor beta chain, Type I interferon receptor 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.