Recombinant Rat Dkk-1 Protein | R&D Systems 4010-DK product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat Dkk-1 Protein

catalog :

4010-DK

quantity :

10 ug

price :

339 USD

citations: 6

Reference
Huang J, Bao Y, Xiang W, Jing X, Guo J, Yao X, et al. Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:8085325 pubmed publisher
Bao J, Ma C, Ran J, Xiong Y, Yan S, Wu L. Wnt/β-catenin and Hedgehog pathways are involved in the inflammatory effect of Interleukin 18 on rat chondrocytes. Oncotarget. 2017;8:109962-109972 pubmed publisher
Kong X, Li X, Zhang C, Zhu L, Liu C, Qin Q, et al. Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways. Int J Biol Sci. 2017;13:480-491 pubmed publisher
Cai T, Sun D, Duan Y, Wen P, Dai C, Yang J, et al. WNT/?-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression. Exp Cell Res. 2016;345:206-17 pubmed publisher
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, et al. REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-Î²-catenin signaling. Oncotarget. 2016;7:12035-52 pubmed publisher
Smith A, Lewis F, Aquila I, Waring C, Nocera A, Agosti V, et al. Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart. Nat Protoc. 2014;9:1662-81 pubmed publisher

product information

brand :

R&D Systems

master code :

4010-DK

SKU :

4010-DK-010

product name :

Recombinant Rat Dkk-1 Protein

description :

The Recombinant Rat Dkk-1 Protein from R&D Systems is derived from NS0.

target :

Dkk-1

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Rat

observed molecular weight :

38-42 kDa, reducing conditions

theoretical molecular weight :

27.6 kDa

details of functionality :

Measured by its ability to inhibit Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells. Recombinant Rat Dkk-1 inhibits a constant dose of 100 ng/mL of Recombinant Mouse Wnt-3a (Catalog # 1324-WN ). The ED50 for this effect is 50-300 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

4010-DK

accessionNumbers :

NP_001099820

source :

Mouse myeloma cell line, NS0-derived rat Dkk-1 protein Ser23-His270, with a C-terminal 6-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

dickkopf (Xenopus laevis) homolog 1, dickkopf homolog 1 (Xenopus laevis), dickkopf related protein-1, Dickkopf-1, dickkopf-related protein 1, Dkk1, DKK-1, hDkk-1, SKdickkopf-1 like

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.