Recombinant Mouse IL-1 alpha/IL-1F1 Protein | R&D Systems 400-ML-005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-1 alpha/IL-1F1 Protein

catalog :

400-ML-005

quantity :

5 ug (also 25 ug)

price :

297 USD

citations: 25

Reference
Donahue K, Watkoske H, Kadiyala P, Du W, Brown K, Scales M, et al. Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024;14:1964-1989 pubmed publisher
LaMarche N, Hegde S, Park M, Maier B, Troncoso L, Le Bérichel J, et al. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024;625:166-174 pubmed publisher
Wang Y, Wu T, Tsai M, Rezzonico M, Abdel Haleem A, Xie L, et al. TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice. elife. 2023;12: pubmed publisher
Matsunami A, Mizuno Kamiya M, Kawaki H, Takayama E, Ueno K, Ando M, et al. Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) vcells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cells. J Oral Biosci. 2021;63:284-291 pubmed publisher
Salmeron K, Maniskas M, Edwards D, Wong R, Rajkovic I, Trout A, et al. Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke. J Neuroinflammation. 2019;16:222 pubmed publisher
Ketelut Carneiro N, Souza C, Benevides L, Gardinassi L, Silva M, Tavares L, et al. Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis. PLoS Pathog. 2019;15:e1007990 pubmed publisher
Lindahl H, Guerreiro Cacais A, Bedri S, Linnerbauer M, Lindén M, Abdelmagid N, et al. IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis. J Immunol. 2019;203:888-898 pubmed publisher
Liu X, Sun Y, Zheng Y, Zhang M, Jin X, Kang K, et al. Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart Transplantation. Cell Physiol Biochem. 2018;49:1180-1196 pubmed publisher
Duncker P, Stoolman J, Huber A, Segal B. GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction. J Immunol. 2018;200:966-973 pubmed publisher
Jiang H, Promchan K, Lin B, Lockett S, Chen D, Marshall H, et al. LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production. J Immunol. 2016;196:1081-90 pubmed publisher
Jules J, Wang S, Shi Z, Liu J, Wei S, Feng X. The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor ÎºB (RANK) Cooperate to Induce Osteoclastogenesis. J Biol Chem. 2015;290:23738-50 pubmed publisher
Lin D, Lei L, Zhang Y, Hu B, Bao G, Liu Y, et al. Secreted IL-1Î± promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice. Eur J Immunol. 2015;45:2084-98 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Chen D, Goswami C, Burnett R, Anjanappa M, Bhat Nakshatri P, Muller W, et al. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle. Cancer Res. 2014;74:4270-81 pubmed publisher
Szewczyk K, Fuller K, Chambers T. Distinctive subdomains in the resorbing surface of osteoclasts. PLoS ONE. 2013;8:e60285 pubmed publisher
Jayaraman P, Sada Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, et al. IL-1? promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013;190:4196-204 pubmed publisher
Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1? controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med. 2012;209:1505-17 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Dienz O, Eaton S, Bond J, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009;206:69-78 pubmed publisher
Chackerian A, Oldham E, Murphy E, Schmitz J, Pflanz S, Kastelein R. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007;179:2551-5 pubmed
Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H. Protection of CD8+ T cells from activation-induced cell death by IL-18. J Leukoc Biol. 2007;82:142-51 pubmed
Wei S, Kitaura H, Zhou P, Ross F, Teitelbaum S. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115:282-90 pubmed
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product information

master code :

400-ML

SKU :

400-ML-005

product name :

Recombinant Mouse IL-1 alpha/IL-1F1 Protein

unit size :

5 ug (also 25 ug)

description :

The Recombinant Mouse IL-1 alpha/IL-1F1 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-1 alpha/IL-1F1 Protein has been validated for the following applications: Bioactivity.

target :

IL-1 alpha/IL-1F1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

18 kDa

gene symbol :

Il1a

details of functionality :

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 3-7 pg/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse IL-1 alpha/IL-1F1 Protein Bioactivity

accessionNumbers :

Q62161

applications :

Bioactivity

source long :

E. coli -derived mouse IL-1 alpha/IL-1F1 protein Ser6-Ser161

source short :

E. coli

USD :

297 USD

alt names :

BAF, Hematopoietin-1, IL1, IL1 alpha, IL-1 alpha, IL1A, IL-1A, IL1-ALPHA, IL1F1, IL-1F1, IL1F1hematopoietin-1, interleukin 1, alpha, interleukin-1 alpha, LAF, LEM, preinterleukin 1 alpha, pro-interleukin-1-alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.