product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-1 alpha/IL-1F1 Protein
catalog :
400-ML-005
quantity :
5 ug (also 25 ug)
price :
294 USD
more info or order :
R&D Systems product webpage
citations: 23
Reference
Wang Y, Wu T, Tsai M, Rezzonico M, Abdel Haleem A, Xie L, et al. TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice. elife. 2023;12: pubmed publisher
Matsunami A, Mizuno Kamiya M, Kawaki H, Takayama E, Ueno K, Ando M, et al. Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) vcells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cells. J Oral Biosci. 2021;63:284-291 pubmed publisher
Salmeron K, Maniskas M, Edwards D, Wong R, Rajkovic I, Trout A, et al. Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke. J Neuroinflammation. 2019;16:222 pubmed publisher
Ketelut Carneiro N, Souza C, Benevides L, Gardinassi L, Silva M, Tavares L, et al. Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis. PLoS Pathog. 2019;15:e1007990 pubmed publisher
Lindahl H, Guerreiro Cacais A, Bedri S, Linnerbauer M, Lindén M, Abdelmagid N, et al. IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis. J Immunol. 2019;203:888-898 pubmed publisher
Liu X, Sun Y, Zheng Y, Zhang M, Jin X, Kang K, et al. Administration of Interleukin-35-Conditioned Autologous Tolerogenic Dendritic Cells Prolong Allograft Survival After Heart Transplantation. Cell Physiol Biochem. 2018;49:1180-1196 pubmed publisher
Duncker P, Stoolman J, Huber A, Segal B. GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction. J Immunol. 2018;200:966-973 pubmed publisher
Jiang H, Promchan K, Lin B, Lockett S, Chen D, Marshall H, et al. LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production. J Immunol. 2016;196:1081-90 pubmed publisher
Jules J, Wang S, Shi Z, Liu J, Wei S, Feng X. The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis. J Biol Chem. 2015;290:23738-50 pubmed publisher
Lin D, Lei L, Zhang Y, Hu B, Bao G, Liu Y, et al. Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice. Eur J Immunol. 2015;45:2084-98 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Chen D, Goswami C, Burnett R, Anjanappa M, Bhat Nakshatri P, Muller W, et al. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle. Cancer Res. 2014;74:4270-81 pubmed publisher
Szewczyk K, Fuller K, Chambers T. Distinctive subdomains in the resorbing surface of osteoclasts. PLoS ONE. 2013;8:e60285 pubmed publisher
Jayaraman P, Sada Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, et al. IL-1? promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013;190:4196-204 pubmed publisher
Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1? controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med. 2012;209:1505-17 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010;84:12703-12 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Dienz O, Eaton S, Bond J, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009;206:69-78 pubmed publisher
Chackerian A, Oldham E, Murphy E, Schmitz J, Pflanz S, Kastelein R. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007;179:2551-5 pubmed
Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H. Protection of CD8+ T cells from activation-induced cell death by IL-18. J Leukoc Biol. 2007;82:142-51 pubmed
Wei S, Kitaura H, Zhou P, Ross F, Teitelbaum S. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115:282-90 pubmed
Scharstuhl A, van Beuningen H, Vitters E, van der Kraan P, van den Berg W. Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann Rheum Dis. 2002;61:1095-8 pubmed
Coope H, Atkinson P, Huhse B, Belich M, Janzen J, Holman M, et al. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J. 2002;21:5375-85 pubmed
image
image 1 :
R&D Systems 400-ML-005 image 1
Recombinant Mouse IL-1 alpha/IL-1F1 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
400-ML
SKU :
400-ML-005
product name :
Recombinant Mouse IL-1 alpha/IL-1F1 Protein
Description :
The Recombinant Mouse IL-1 alpha/IL-1F1 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-1 alpha/IL-1F1 Protein has been validated for the following applications: Bioactivity.
target :
IL-1 alpha/IL-1F1
category :
Proteins and Enzymes
unit size :
5 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
18 kDa
gene symbol :
Il1a
details of functionality :
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 272. The ED50 for this effect is 3-7 pg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62161
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse IL-1 alpha/IL-1F1 Protein
USD :
294 USD
alt names :
BAF, Hematopoietin-1, IL1, IL1 alpha, IL-1 alpha, IL1A, IL-1A, IL1-ALPHA, IL1F1, IL-1F1, IL1F1hematopoietin-1, interleukin 1, alpha, interleukin-1 alpha, LAF, LEM, preinterleukin 1 alpha, pro-interleukin-1-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.