Recombinant Human Leptin Protein, CF | R&D Systems 398-LP-01M product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Leptin Protein, CF

catalog :

398-LP-01M

quantity :

1 mg (also 5 mg)

price :

249 USD

more info or order :

R&D Systems product webpage

citations: 38

Reference
Kayashima Y, Townley Tilson W, Vora N, Boggess K, Homeister J, Maeda Smithies N, et al. Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice. Int J Mol Sci. 2023;24: pubmed publisher
Wei J, Huang X, Zhang X, Chen G, Zhang C, Zhou X, et al. Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway. Cell Death Dis. 2023;14:97 pubmed publisher
Watanabe K, Suzukawa M, Kawauchi Watanabe S, Igarashi S, Asari I, Imoto S, et al. Leptin-producing monocytes in the airway submucosa may contribute to asthma pathogenesis. Respir Investig. 2023;61:5-15 pubmed publisher
Mourmoura E, Papathanasiou I, Trachana V, Konteles V, Tsoumpou A, Goutas A, et al. Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS. Mech Ageing Dev. 2022;208:111730 pubmed publisher
Wang X, Shen Y, Ke X, Kang H, Hong S. Role of leptin/ILC2 axis in allergic rhinitis in obese children. Int J Pediatr Otorhinolaryngol. 2022;157:111127 pubmed publisher
Gao M, Ge M, Huo J, Ren X, Li X, Shao Y, et al. Leptin-mediated proinflammatory bone marrow environment in acquired aplastic anemia. Cytokine. 2022;152:155829 pubmed publisher
Thomas I, Panagoulias I, Aggeletopoulou I, Varvarigou A, Spiliotis B, Mouzaki A. The Role of Leptin in Childhood Immune Thrombocytopenia (ITP): An Anti-Inflammatory Agent?. Int J Mol Sci. 2021;22: pubmed publisher
Leibiger B, Moede T, Valladolid Acebes I, Paschen M, Visa M, Leibiger I, et al. Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice. Metabolites. 2021;11: pubmed publisher
Crabtree D, Buosi W, Fyfe C, Horgan G, Manios Y, Androutsos O, et al. Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project. Nutrients. 2020;12: pubmed publisher
Ewbank S, Campos C, Chen J, Bowen A, Padilla S, Dempsey J, et al. Chronic Gq signaling in AgRP neurons does not cause obesity. Proc Natl Acad Sci U S A. 2020;117:20874-20880 pubmed publisher
Gu F, Zhang H, Yao L, Jiang S, Lu H, Xing X, et al. Leptin contributes to the taxol chemoresistance in epithelial ovarian cancer. Oncol Lett. 2019;18:561-570 pubmed publisher
Watanabe K, Suzukawa M, Arakawa S, Kobayashi K, Igarashi S, Tashimo H, et al. Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor. Allergol Int. 2019;: pubmed publisher
Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, et al. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis. 2018;9:556 pubmed publisher
Oswald J, Büttner M, Jasinski Bergner S, Jacobs R, Rosenstock P, Kielstein H. Leptin affects filopodia and cofilin in NK-92 cells in a dose- and time-dependent manner. Eur J Histochem. 2018;62:2848 pubmed publisher
Riu F, Slater S, Garcia E, Rodriguez Arabaolaza I, Alvino V, Avolio E, et al. The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling. Sci Rep. 2017;7:5443 pubmed publisher
Daley Brown D, Oprea Iles G, Vann K, Lanier V, Lee R, Candelaria P, et al. Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation. Dis Markers. 2017;2017:8248175 pubmed publisher
Harbuzariu A, Rampoldi A, Daley Brown D, Candelaria P, Harmon T, Lipsey C, et al. Leptin-Notch signaling axis is involved in pancreatic cancer progression. Oncotarget. 2017;8:7740-7752 pubmed publisher
Hart R, Dobos R, Agnew L, Smart N, McFarlane J. Leptin pharmacokinetics in male mice. Endocr Connect. 2017;6:20-26 pubmed publisher
Chang C, Wu M, Yang J, CAMARILLO I, Chang C. Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression. Cancer Res. 2015;75:2375-2386 pubmed publisher
Tadokoro S, Ide S, Tokuyama R, Umeki H, Tatehara S, Kataoka S, et al. Leptin promotes wound healing in the skin. PLoS ONE. 2015;10:e0121242 pubmed publisher
Liu T, Zhang Y, Liu Y, Wang Y, Jia H, Kang M, et al. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists. Proc Natl Acad Sci U S A. 2015;112:1356-61 pubmed publisher
Huang G, Li J, Wang H, Lan X, Wang Y. Discovery of a novel functional leptin protein (LEP) in zebra finches: evidence for the existence of an authentic avian leptin gene predominantly expressed in the brain and pituitary. Endocrinology. 2014;155:3385-96 pubmed publisher
Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, et al. Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration. Br J Cancer. 2014;110:1801-10 pubmed publisher
Libraty D, Zhang L, Woda M, Giaya K, Kathivu C, Acosta L, et al. Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model. PLoS ONE. 2014;9:e88944 pubmed publisher
Lo H, Lai T, Li C, Wu W. TNF-? induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin. 2014;35:339-50 pubmed publisher
Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J. Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1. Cytokine. 2014;65:222-30 pubmed publisher
Schroeter M, Eschholz N, Herzberg S, Jerchel I, Leifheit Nestler M, Czepluch F, et al. Leptin-dependent and leptin-independent paracrine effects of perivascular adipose tissue on neointima formation. Arterioscler Thromb Vasc Biol. 2013;33:980-7 pubmed publisher
Jaedicke K, Roythorne A, Padget K, Todryk S, Preshaw P, Taylor J. Leptin up-regulates TLR2 in human monocytes. J Leukoc Biol. 2013;93:561-71 pubmed publisher
Lam K, Chiu P, Lee C, Pang R, Leung C, Koistinen H, et al. Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. J Biol Chem. 2011;286:37118-27 pubmed publisher
Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J Immunol. 2011;186:5254-60 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Procopio C, Andreozzi F, Laratta E, Cassese A, Beguinot F, Arturi F, et al. Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein. Endocrinology. 2009;150:3584-93 pubmed publisher
Dellas C, Schafer K, Rohm I, Lankeit M, Ellrott T, Faustin V, et al. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost. 2008;100:1123-9 pubmed
Emsley H, Smith C, Gavin C, Georgiou R, Vail A, Barberan E, et al. Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol. 2007;7:5 pubmed
Durakoglugil M, Irving A, Harvey J. Leptin induces a novel form of NMDA receptor-dependent long-term depression. J Neurochem. 2005;95:396-405 pubmed
Wunder D, Mueller M, Birkhäuser M, Bersinger N. Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis. J Assist Reprod Genet. 2005;22:257-64 pubmed
Mistrik P, Moreau F, Allen J. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Anal Biochem. 2004;327:271-7 pubmed
Kaser S, Kaser A, Vogel W, Patsch J, Tilg H. Interferon-alpha suppresses leptin levels: studies in interferon-alpha treated patients with hepatitis C virus infection and murine adipocytes. Eur Cytokine Netw. 2002;13:225-9 pubmed

image

image 1 :

Recombinant Human Leptin Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

398-LP

SKU :

398-LP-01M

product name :

Recombinant Human Leptin Protein, CF

Description :

The Recombinant Human Leptin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Leptin Protein, CF has been validated for the following applications: Bioactivity.

target :

Leptin/OB

category :

Proteins and Enzymes

unit size :

1 mg (also 5 mg)

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-HCl and NaCl.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

theoretical molecular weight :

16 kDa

gene symbol :

LEP

details of functionality :

Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human Leptin R. The ED50 for this effect is 0.4-2 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6NT58

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Leptin Protein

USD :

249 USD

alt names :

FLJ94114, LEP, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage